Corrigendum to “3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy” [Acta Biomater. 73 (2018) 531–546]

2019 ◽  
Vol 89 ◽  
pp. 421-424 ◽  
Author(s):  
Yaqin Liu ◽  
Tao Li ◽  
Hongshi Ma ◽  
Dong Zhai ◽  
Cuijun Deng ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
3D Printed

3D-printed scaffolds with bioactive elements-induced photothermal effect for bone tumor therapy

2018 ◽  
Vol 73 ◽  
pp. 531-546 ◽  
Author(s):  
Yaqin Liu ◽  
Tao Li ◽  
Hongshi Ma ◽  
Dong Zhai ◽  
Cuijun Deng ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
3D Printed

Black plasma-sprayed Ta2O5 coatings with photothermal effect for bone tumor therapy

2018 ◽  
Vol 44 (11) ◽  
pp. 12002-12006 ◽  
Author(s):  
Ding Ding ◽  
Youtao Xie ◽  
Kai Li ◽  
Liping Huang ◽  
Xuebin Zheng
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
Plasma Sprayed

scholarly journals The Development Tendency of 3D-Printed Bioceramic Scaffolds for Applications Ranging From Bone Tissue Regeneration to Bone Tumor Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Zhixiang Fang ◽  
Jihang Chen ◽  
Jiangxia Pan ◽  
Guoqiang Liu ◽  
Chen Zhao
Keyword(s):  
Tissue Engineering ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Bone Tumor ◽  
Physiological Activity ◽  
Tumor Therapy ◽  
Bone Tissue Regeneration ◽  
Tumor Treatment ◽  
3D Printed

Three-dimensional (3D) printing concept has been successfully employed in regenerative medicine to achieve individualized therapy due to its benefit of a rapid, accurate, and predictable production process. Traditional biocomposites scaffolds (SCF) are primarily utilised for bone tissue engineering; nevertheless, over the last few years, there has already been a dramatic shift in the applications of bioceramic (BCR) SCF. As a direct consequence, this study focused on the structural, degeneration, permeation, and physiological activity of 3D-printed BCR (3DP-B) SCF with various conformations and work systems (macros, micros, and nanos ranges), as well as their impacts on the mechanical, degeneration, porosity, and physiological activities. In addition, 3DP-B SCF are highlighted in this study for potential uses applied from bone tissue engineering (BTE) to bone tumor treatment. The study focused on significant advances in practical 3DP-B SCF that can be utilized for tumor treatment as well as bone tissue regeneration (BTR). Given the difficulties in treating bone tumors, these operational BCR SCF offer a lot of promise in mending bone defects caused by surgery and killing any remaining tumor cells to accomplish bone tumor treatment. Furthermore, a quick assessment of future developments in this subject was presented. The study not only summarizes recent advances in BCR engineering, but it also proposes a new therapeutic strategy focused on the extension of conventional ceramics’ multifunction to a particular diagnosis.

scholarly journals Review of a new bone tumor therapy strategy based on bifunctional biomaterials

Bone Research ◽  
2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jinfeng Liao ◽  
Ruxia Han ◽  
Yongzhi Wu ◽  
Zhiyong Qian
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tumor ◽  
Bone Tumors ◽  
Tumor Therapy ◽  
Postoperative Recurrence ◽  
Therapy Strategy ◽  
New Strategy ◽  
Recent Developments ◽  
3D Printed

AbstractBone tumors, especially those in osteosarcoma, usually occur in adolescents. The standard clinical treatment includes chemotherapy, surgical therapy, and radiation therapy. Unfortunately, surgical resection often fails to completely remove the tumor, which is the main cause of postoperative recurrence and metastasis, resulting in a high mortality rate. Moreover, bone tumors often invade large areas of bone, which cannot repair itself, and causes a serious effect on the quality of life of patients. Thus, bone tumor therapy and bone regeneration are challenging in the clinic. Herein, this review presents the recent developments in bifunctional biomaterials to achieve a new strategy for bone tumor therapy. The selected bifunctional materials include 3D-printed scaffolds, nano/microparticle-containing scaffolds, hydrogels, and bone-targeting nanomaterials. Numerous related studies on bifunctional biomaterials combining tumor photothermal therapy with enhanced bone regeneration were reviewed. Finally, a perspective on the future development of biomaterials for tumor therapy and bone tissue engineering is discussed. This review will provide a useful reference for bone tumor-related disease and the field of complex diseases to combine tumor therapy and tissue engineering.

Bifunctional scaffolds of hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with osteogenesis and anti-osteosarcoma effect

2021 ◽  
Author(s):  
Mengyu Yao ◽  
Qingxia Zou ◽  
Wenwu Zou ◽  
Zhenze Xie ◽  
Zhihao Li ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Therapy ◽  
Carboxymethyl Chitosan

Bifunctional scaffolds prepared by hydroxyapatite/poly(dopamine)/carboxymethyl chitosan with good osteogenesis and anti-osteosarcoma effect is promising for bone tumor therapy.

scholarly journals The application of 3D printed surgical guides in resection and reconstruction of malignant bone tumor

2017 ◽  
Vol 14 (4) ◽  
pp. 4581-4584 ◽  
Author(s):  
Fengping Wang ◽  
Jun Zhu ◽  
Xuejun Peng ◽  
Jing Su
Keyword(s):  
Bone Tumor ◽  
Malignant Bone Tumor ◽  
Surgical Guides ◽  
3D Printed

scholarly journals Bifunctional, Copper-Doped, Mesoporous Silica Nanosphere-Modified, Bioceramic Scaffolds for Bone Tumor Therapy

2020 ◽  
Vol 8 ◽  
Author(s):  
Hongshi Ma ◽  
Zhenjiang Ma ◽  
Qufei Chen ◽  
Wentao Li ◽  
Xiangfei Liu ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Tumor Cells ◽  
Bone Tumor ◽  
Checkpoint Inhibitors ◽  
Tumor Therapy ◽  
Residual Tumor ◽  
Bone Defects ◽  
Silica Nanosphere ◽  
Large Bone ◽  
Large Bone Defects

In the traditional surgical intervention procedure, residual tumor cells may potentially cause tumor recurrence. In addition, large bone defects caused by surgery are difficult to self-repair. Thus, it is necessary to design a bioactive scaffold that can not only kill residual tumor cells but also promote bone defect regeneration simultaneously. Here, we successfully developed Cu-containing mesoporous silica nanosphere-modified β-tricalcium phosphate (Cu-MSN-TCP) scaffolds, with uniform and dense nanolayers with spherical morphology via 3D printing and spin coating. The scaffolds exhibited coating time- and laser power density-dependent photothermal performance, which favored the effective killing of tumor cells under near-infrared laser irradiation. Furthermore, the prepared scaffolds favored the proliferation and attachment of rabbit bone marrow-derived mesenchymal stem cells and stimulated the gene expression of osteogenic markers. Overall, Cu-MSN-TCP scaffolds can be considered for complete eradication of residual bone tumor cells and simultaneous healing of large bone defects, which may provide a novel and effective strategy for bone tumor therapy. In the future, such Cu-MSN-TCP scaffolds may function as carriers of anti-cancer drugs or immune checkpoint inhibitors in chemo-/photothermal or immune-/photothermal therapy of bone tumors, favoring for effective treatment.

scholarly journals Hyaluronic acid modified covalent organic polymers for efficient targeted and oxygen-evolved phototherapy

2020 ◽  
Author(s):  
Fangpeng Shu ◽  
Taowei Yang ◽  
Xuefeng Zhang ◽  
Wenbin Chen ◽  
Kaihui Wu ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Combined Therapy ◽  
Tumor Therapy ◽  
Photothermal Effect ◽  
Organic Polymers ◽  
New Paradigm

Abstract The integration of multiple functions with organic polymers-based nanoagent holds great potential to potentiate its therapeutic efficacy, but still remains challenges. In the present study, we design and prepare an organic nanoagent with oxygen-evolved and targeted ability for improved phototherapeutic efficacy. The iron ions doped poly diaminopyridine (FeD) is prepared by oxidize polymerization and modified with hyaluronic acid (HA). The obtained FeDH appears uniform morphology and size. Its excellent colloidal stability and biocompatibility are demonstrated. Specifically, the FeDH exhibits catalase-like activity in the presence of hydrogen peroxide. After loading of photosensitizer indocyanine green (ICG), the ICG@FeDH not only demonstrates favorable photothermal effect, but also shows improved generation ability of reactive oxygen species (ROS) under near-infrared laser irradiation. Moreover, the targeted uptake of ICG@FeDH in tumor cells is directly observed. As consequence, the superior phototherapeutic efficacy of the targeted ICG@FeDH over non-targeted counterparts is also confirmed in vitro and in vivo. Hence, the results demonstrate that the developed nanoagent rationally integrates the targeted ability, oxygen-evolved capacity and combined therapy in one system, offering a new paradigm of polymer-based nanomedicine for tumor therapy.

Improving Cutting Path on Custom 3D-Printed Surgical Guides for Bone-Tumor Resection

2019 ◽  
Author(s):  
Carlos G. Helguero ◽  
Juan Castro ◽  
César Ochoa ◽  
Fausto Maldonado ◽  
Emilio A. Ramírez ◽  
...  
Keyword(s):  
Bone Tumor ◽  
Tumor Resection ◽  
Three Dimensional ◽  
Element Analysis ◽  
Surgical Guides ◽  
Orthopedic Oncology ◽  
3D Printed ◽  
Bone Tumor Resection ◽  
High Level ◽  
Cutting Path

Abstract Custom three-dimensional (3D) printed guides are being used in the operative room as an aid to surgeons for increasing the accuracy of their cutting and resection techniques. In terms of bone-tumor resection, the cutting path printed in the custom jig is significantly important for two main purposes: first, the required fit for the implant that will replace the resected bone section and, second, the interaction between the remaining, healthy bone and the new implant in terms of forces, stresses and deformation. Bone tumor resection has posed a challenge in orthopedic oncology, specifically due to a high level of difficulty in performing a limb-sparing surgery with negative margins on the remaining bone. A straight cutting path is usually used in clinical procedures due to the type of tooling available inside the operative room. 3D printed cutting path guides offer the possibility to evolve from a straight to a different path, e.g. a tapered path, and overcome fitting problems during surgery. This work investigates the current straight cutting path used for typical bone tumor resection and compares it to a proposed tapered cutting path in terms of both implant fitting and stress analysis. Finite element analysis software is used to simulate a compression force exerted over the femur bone. Different taper cut angles are studied and results are reported to obtain an ideal angle for resection. Results are presented to evidence the need to evolve from the current resection technique in order to minimize the number of revision surgeries and for a better quality of life of patients under this type of surgical procedure.

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