scholarly journals BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma

2021 ◽  
Author(s):  
Casey E. Vantucci ◽  
Laxminarayanan Krishan ◽  
Albert Cheng ◽  
Ayanna Prather ◽  
Krishnendu Roy ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Delivery System ◽  
Collagen Sponge ◽  
Bone Morphogenetic Protein 2 ◽  
Delivery Strategy ◽  
Local Bone ◽  
Morphogenetic Protein ◽  
Extremity Trauma

Bone nonunions remain compelling orthopedic challenges. Bone morphogenetic protein-2 (BMP-2) delivered in a heparin microparticle (HMP) delivery system improved local bone regeneration compared to BMP-2 delivered in the clinical standard collagen sponge.

Design of hydroxyapatite bioceramics with micro-/nano-topographies to regulate the osteogenic activities of bone morphogenetic protein-2 and bone marrow stromal cells

Nanoscale ◽  
2020 ◽  
Vol 12 (13) ◽  
pp. 7284-7300 ◽  
Author(s):  
Xiangfeng Li ◽  
Minjun Liu ◽  
Fuying Chen ◽  
Yuyi Wang ◽  
Menglu Wang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Natural Bone ◽  
Morphogenetic Protein ◽  
Bone Apatite

Biomimicking the nanostructure of natural bone apatite to enhance the bioactivity of hydroxyapatite (HA) biomaterials is an eternal topic in the bone regeneration field.

A doxycycline inducible, adenoviral bone morphogenetic protein-2 gene delivery system to bone

2017 ◽  
Vol 12 (1) ◽  
pp. e106-e118 ◽  
Author(s):  
Jennifer J. Bara ◽  
Iska Dresing ◽  
Stephan Zeiter ◽  
Martina Anton ◽  
Guy Daculsi ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Bone Morphogenetic Protein ◽  
Delivery System ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System ◽  
Morphogenetic Protein
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