A doxycycline inducible, adenoviral bone morphogenetic protein-2 gene delivery system to bone

2017 ◽  
Vol 12 (1) ◽  
pp. e106-e118 ◽  
Author(s):  
Jennifer J. Bara ◽  
Iska Dresing ◽  
Stephan Zeiter ◽  
Martina Anton ◽  
Guy Daculsi ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Bone Morphogenetic Protein ◽  
Delivery System ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System ◽  
Morphogenetic Protein

scholarly journals Mesenchymal Stem Cell-mediated Gene Delivery of Bone Morphogenetic Protein-2 in an Articular Fracture Model

2007 ◽  
Vol 15 (8) ◽  
pp. 1543-1550 ◽  
Author(s):  
Terri Zachos ◽  
Alisha Diggs ◽  
Steven Weisbrode ◽  
Jeffrey Bartlett ◽  
Alicia Bertone
Keyword(s):  
Stem Cell ◽  
Gene Delivery ◽  
Mesenchymal Stem Cell ◽  
Bone Morphogenetic Protein ◽  
Fracture Model ◽  
Bone Morphogenetic Protein 2 ◽  
Articular Fracture ◽  
Morphogenetic Protein

scholarly journals BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma

2021 ◽  
Author(s):  
Casey E. Vantucci ◽  
Laxminarayanan Krishan ◽  
Albert Cheng ◽  
Ayanna Prather ◽  
Krishnendu Roy ◽  
...  
Keyword(s):  
Immune Responses ◽  
Bone Regeneration ◽  
Bone Morphogenetic Protein ◽  
Delivery System ◽  
Collagen Sponge ◽  
Bone Morphogenetic Protein 2 ◽  
Delivery Strategy ◽  
Local Bone ◽  
Morphogenetic Protein ◽  
Extremity Trauma

Bone nonunions remain compelling orthopedic challenges. Bone morphogenetic protein-2 (BMP-2) delivered in a heparin microparticle (HMP) delivery system improved local bone regeneration compared to BMP-2 delivered in the clinical standard collagen sponge.

scholarly journals Enhanced Transfection of Human Mesenchymal Stem Cells Using a Hyaluronic Acid/Calcium Phosphate Hybrid Gene Delivery System

Polymers ◽  
2019 ◽  
Vol 11 (5) ◽  
pp. 798 ◽  
Author(s):  
Jung Eun Lee ◽  
Yue Yin ◽  
Su Yeon Lim ◽  
E. Seul Kim ◽  
Jaeback Jung ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Hyaluronic Acid ◽  
Calcium Phosphate ◽  
Gene Delivery ◽  
Delivery System ◽  
Gene Transfection ◽  
Human Mesenchymal Stem Cells ◽  
Bone Morphogenetic Protein 2 ◽  
Gene Delivery System

Human mesenchymal stem cells (hMSCs) show enormous potential in regenerative medicine and tissue engineering. However, current use of hMSCs in clinics is still limited because there is no appropriate way to control their behavior in vivo, such as differentiation to a desired cell type. Genetic modification may provide an opportunity to control the cells in an active manner. One of the major hurdles for genetic manipulation of hMSCs is the lack of an efficient and safe gene delivery system. Herein, biocompatible calcium phosphate (CaP)-based nanoparticles stabilized with a catechol-derivatized hyaluronic acid (dopa-HA) conjugate were used as a carrier for gene transfection to hMSCs for improved differentiation. Owing to the specific interactions between HA and CD44 of bone marrow-derived hMSCs, dopa-HA/CaP showed significantly higher transfection in hMSCs than branched polyethylenimine (bPEI, MW 25 kDa) with no cytotoxicity. The co-delivery of a plasmid DNA encoding bone morphogenetic protein 2 (BMP-2 pDNA) and micro RNA 148b (miRNA-148b) by dopa-HA/CaP achieved significantly improved osteogenic differentiation of hMSCs.

Gene delivery of bone morphogenetic protein-2 plasmid DNA promotes bone formation in a large animal model

2012 ◽  
Vol 8 (10) ◽  
pp. 763-770 ◽  
Author(s):  
Fiona Wegman ◽  
Ruth E. Geuze ◽  
Yvonne J. van der Helm ◽  
F. Cumhur Öner ◽  
Wouter J.A. Dhert ◽  
...  
Keyword(s):  
Animal Model ◽  
Gene Delivery ◽  
Bone Formation ◽  
Bone Morphogenetic Protein ◽  
Plasmid Dna ◽  
Bone Morphogenetic Protein 2 ◽  
Large Animal Model ◽  
Large Animal ◽  
Morphogenetic Protein

A Novel Biodegradable Delivery System for Bone Morphogenetic Protein-2

2008 ◽  
Vol 121 (6) ◽  
pp. 1920-1928 ◽  
Author(s):  
Thomas Engstrand ◽  
Riikka Veltheim ◽  
Claes Arnander ◽  
Ann-Charlott Docherty-Skogh ◽  
Anders Westermark ◽  
...  
Keyword(s):  
Bone Morphogenetic Protein ◽  
Delivery System ◽  
Bone Morphogenetic Protein 2 ◽  
Morphogenetic Protein
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