Homogeneous and efficient production of a bacterial nanocellulose-lactoferrin-collagen composite under an electric field as a matrix to promote wound healing

2021 ◽  
Author(s):  
Haibin Yuan ◽  
Lin Chen ◽  
Feng F. Hong
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Electric Field ◽  
Therapeutic Effect ◽  
Efficient Production ◽  
Bacterial Nanocellulose ◽  
Promote Wound Healing ◽  
Water Holding

A novel BNC/LF/COL membrane fabricated using an electrophoresis-based technology showed superior advantages in water-holding capability and antibacterial activity, with higher cytocompatibility as well as greater therapeutic effect in wound healing.

A moisture balanced antibacterial dressing loaded with lysozyme possesses antibacterial activity and promotes wound healing

Soft Matter ◽  
2021 ◽  
Vol 17 (11) ◽  
pp. 3162-3173
Author(s):  
Ling Xiao ◽  
Wenqiang Ni ◽  
Xiaohong Zhao ◽  
Yicheng Guo ◽  
Xue Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Promote Wound Healing

An antibacterial moisture balanced dressing is designed to fight infection and promote wound healing.

Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy

2020 ◽  
Vol 318 (5) ◽  
pp. C848-C856 ◽  
Author(s):  
Rongfeng Shi ◽  
Yinpeng Jin ◽  
Weiwei Hu ◽  
Weishuai Lian ◽  
Chuanwu Cao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Therapeutic Effect ◽  
Diabetic Rats ◽  
Luciferase Reporter Assay ◽  
Luciferase Reporter ◽  
Reporter Assay ◽  
High Concentration ◽  
Promote Wound Healing

More and more evidence advises that circular RNAs (circRNAs) function critically in regulating different disease microenvironments. Our previous study found that autotransplantation of adipose-derived mesenchymal stem cells (ADSCs) promotes diabetes wound healing. Exosomes derived in ADSCs play an important regulatory role. This study aimed to characterize if mmu_circ_0000250 played a role in ADSC-exosome-mediated full-thickness skin wound repair in diabetic rats. Endothelial progenitor cells (EPCs) were selected to study the therapeutic mechanism of exosomes in high-glucose (HG)-induced cell damage and dysfunction. Analysis and luciferase reporter assay were utilized to explore the interaction among mmu_circ_0000250, miRNA (miR)-128-3p, and sirtuin (SIRT)1. The diabetic rats were used to confirm the therapeutic effect of mmu_circ_0000250 against exosome-mediated wound healing. Exosomes containing a high concentration of mmu_circ_0000250 had a greater therapeutic effect on restoration of the function of EPCs by promotion autophagy activation under HG conditions. Expression of mmu_circ_0000250 promoted SIRT1 expression by miR-128-3p adsorption, which was confirmed via luciferase reporter assay and bioinformatics analysis. In vivo, exosomes containing a high concentration of mmu_circ_0000250 had a more therapeutic effect on wound healing when compared with wild-type exosomes from ADSCs. Immunohistochemistry and immunofluorescence detection showed that mmu_circ_0000250 increased angiopoiesis with exosome treatment in wound skin and suppressed apoptosis by autophagy activation. In conclusion, we verified that mmu_circ_0000250 enhanced the therapeutic effect of ADSC-exosomes to promote wound healing in diabetes by absorption of miR-128-3p and upregulation of SIRT1. Therefore, these findings advocate targeting the mmu_circ_0000250/miR-128-3p/SIRT1 axis as a candidate therapeutic option for diabetic ulcers.

APPLICATIONS OF CHITOSAN-SULFATHIAZOLE AS ANTIMICROBIAL AGENT

2018 ◽  
Vol 28 (2) ◽  
pp. 429-432
Author(s):  
Dilyana Zvezdova
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Fourier Transform ◽  
Infrared Spectroscopy ◽  
Antimicrobial Agent ◽  
Defense Mechanisms ◽  
Solvent Casting ◽  
Casting Method ◽  
Gram Negative ◽  
Positively Charged

Chitosan, a hydrophilic biopolymer industrially obtained by N-deacetylation of chitin, can be applied as an antimicrobial agent. It highlights the applications of chitosan as an antimicrobial agent against fungi, bacteria, and viruses and as an elicitor of plant defense mechanisms. A series of novel chitosan-sulfathiazole nanocomposite (CSFZ) films were prepared by using solvent casting method for wound healing application. Fourier transform infrared spectroscopy (FTIR) was employed to ascertain the interaction between negatively charged sulfathiazole and positively charged chitosan. Moreover, the antibacterial activity of the films was investigated against gram positive and gram negative microorganisms. It was found that all CSFZ films showed good inhibitory activity against all the tested bacteria as compared to control. The above analysis suggested that the CSFZ films could be used as potential candidates for wound healing application.

A Fe3+-crosslinked pyrogallol-tethered gelatin adhesive hydrogel with antibacterial activity for wound healing

2020 ◽  
Vol 8 (11) ◽  
pp. 3164-3172 ◽  
Author(s):  
Ning Han ◽  
Ziyang Xu ◽  
Chunyan Cui ◽  
Yuan Li ◽  
Dongfei Zhang ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Strong Adhesion ◽  
Mixing Method ◽  
Antibacterial Capacity

A tunicate-inspired gelatin-based hydrogel prepared by a simple mixing method, exhibits strong adhesion and antibacterial capacity, and facilitates wound healing.

scholarly journals The Wound Healing and Antibacterial Activity of Five Ethnomedical Calophyllum inophyllum Oils: An Alternative Therapeutic Strategy to Treat Infected Wounds

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0138602 ◽  
Author(s):  
Teddy Léguillier ◽  
Marylin Lecsö-Bornet ◽  
Christelle Lémus ◽  
Delphine Rousseau-Ralliard ◽  
Nicolas Lebouvier ◽  
...  
Keyword(s):  
Wound Healing ◽  
Antibacterial Activity ◽  
Therapeutic Strategy ◽  
Calophyllum Inophyllum ◽  
Infected Wounds

Melittin and diclofenac synergistically promote wound healing in a pathway involving TGF-β1

2021 ◽  
pp. 105993
Author(s):  
Basma G. Eid ◽  
Nabil A. Alhakamy ◽  
Usama A. Fahmy ◽  
Osama A.A. Ahmed ◽  
Shadab Md ◽  
...  
Keyword(s):  
Wound Healing ◽  
Promote Wound Healing ◽  
Tgf Β1
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