Scaffold-supported extracellular matrices preserved by magnesium hydroxide nanoparticles for renal tissue regeneration

2020 ◽  
Vol 8 (19) ◽  
pp. 5427-5440 ◽  
Author(s):  
Yun Ah Kim ◽  
So Young Chun ◽  
Sung-Bin Park ◽  
Eunyoung Kang ◽  
Won-Gun Koh ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Magnesium Hydroxide ◽  
Renal Tissue ◽  
Extracellular Matrices ◽  
Magnesium Hydroxide Nanoparticles

Fibroblast-derived extracellular matrix-supported scaffolds made up of PLGA were prepared with the enhanced preservation of ECM components by composites with magnesium hydroxide nanoparticles, and were applied for renal tissue regeneration.

Extracellular matrices derived from different cell sources and their effect on macrophage behavior and wound healing

2020 ◽  
Vol 8 (42) ◽  
pp. 9744-9755
Author(s):  
Cininta Savitri ◽  
Sang Su Ha ◽  
Emily Liao ◽  
Ping Du ◽  
Kwideok Park
Keyword(s):  
Extracellular Matrix ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Extracellular Matrices ◽  
Cell Sources

Cell-derived extracellular matrix is an excellent biomaterial toward tissue regeneration, due to its physiologically relevant characteristics for specific tissues and organs.

scholarly journals Rosehip Extract-Functionalized Magnesium Hydroxide Nanoparticles and Its Effect on Osteoblastic and Osteoclastic Cells

Materials ◽  
2021 ◽  
Vol 14 (15) ◽  
pp. 4172
Author(s):  
Laura Costa Pinho ◽  
Thais Francini Garbieri ◽  
Liliana Grenho ◽  
Marta M. Alves ◽  
Pedro Sousa Gomes ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Magnesium Hydroxide ◽  
Pure Water ◽  
Cell Types ◽  
Xrd Analysis ◽  
Osteoblastic Differentiation ◽  
Tartrate Resistant Acid Phosphatase ◽  
Alp Activity ◽  
Mean Diameter ◽  
Magnesium Hydroxide Nanoparticles

Considering the role of magnesium in bone metabolism and the increasing relevance of plant-mediated green-synthesis, this work compares the bone cytocompatibility of magnesium hydroxide nanoparticles (NPs) produced by using pure water, Mg(OH)2, or a rosehip (RH) aqueous extract, Mg(OH)2RH. The NPs were evaluated for dose- and time-dependent effects on human osteoblastic and osteoclastic response, due to the direct involvement of the two cell types in bone metabolism. Mg(OH)2 NPs presented nanoplatelet-like morphology (mean diameter ~90 nm) and a crystalline structure (XRD analysis); the RH-mediated synthesis yielded smaller rounded particles (mean diameter <10 nm) with decreased crystallinity. On the ATR–FTIR spectra, both NPs presented the characteristic Mg-OH peaks; Mg(OH)2RH exhibited additional vibration bands associated with the presence of phytochemicals. On osteoblastic cells, NPs did not affect cell growth and morphology but significantly increased alkaline phosphatase (ALP) activity; on osteoclastic cells, particles had little effect in protein content, tartrate-resistant acid phosphatase (TRAP) activity, percentage of multinucleated cells, and cell area. However, compared with Mg(OH)2, Mg(OH)2RH increased osteoblastic differentiation by inducing ALP activity and promoting the expression of Runx2, SP7, Col1a1, and ALP, and had a negative effect on the expression of the osteoclastic genes NFATC1, CA2, and CTSK. These observations suggest the potential usefulness of Mg(OH)2RH NPs in bone regeneration.

scholarly journals Extracellular matrix‐based scaffolding technologies for periodontal and peri‐implant soft tissue regeneration

2019 ◽  
Vol 91 (1) ◽  
pp. 17-25 ◽  
Author(s):  
Lorenzo Tavelli ◽  
Michael K. McGuire ◽  
Giovanni Zucchelli ◽  
Giulio Rasperini ◽  
Stephen E. Feinberg ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

Preparation of lamellar magnesium hydroxide nanoparticles via precipitation method

2009 ◽  
Vol 191 (3) ◽  
pp. 227-230 ◽  
Author(s):  
Wenjun Jiang ◽  
Xiao Hua ◽  
Qiaofeng Han ◽  
Xujie Yang ◽  
Lude Lu ◽  
...  
Keyword(s):  
Magnesium Hydroxide ◽  
Precipitation Method ◽  
Magnesium Hydroxide Nanoparticles

Biomimetic Porous PLGA Scaffolds Incorporating Decellularized Extracellular Matrix for Kidney Tissue Regeneration

2016 ◽  
Vol 8 (33) ◽  
pp. 21145-21154 ◽  
Author(s):  
Eugene Lih ◽  
Ki Wan Park ◽  
So Young Chun ◽  
Hyuncheol Kim ◽  
Tae Gyun Kwon ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Tissue Regeneration ◽  
Kidney Tissue ◽  
Decellularized Extracellular Matrix
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