A low-intensity focused ultrasound-assisted nanocomposite for advanced triple cancer therapy: local chemotherapy, therapeutic extracellular vesicles and combined immunotherapy

2020 ◽  
Vol 8 (23) ◽  
pp. 6703-6717
Author(s):  
Mixiao Tan ◽  
Yuli Chen ◽  
Yuan Guo ◽  
Chao Yang ◽  
Mingzhu Liu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Extracellular Vesicles ◽  
Focused Ultrasound ◽  
Local Chemotherapy ◽  
Low Intensity ◽  
Ultrasound Assisted ◽  
Triple Cancer ◽  
Combined Immunotherapy

CCs-SF/DOX nanocomposite based triple therapies of “local chemotherapy-therapeutic EVs-synergistic immunotherapy” irradiated by LIFU.

Peptide-Functionalized Phase-Transformation Nanoparticles for Low Intensity Focused Ultrasound-Assisted Tumor Imaging and Therapy

Nano Letters ◽  
2018 ◽  
Vol 18 (3) ◽  
pp. 1831-1841 ◽  
Author(s):  
LeiLei Zhu ◽  
HongYun Zhao ◽  
ZhiYi Zhou ◽  
YongHong Xia ◽  
ZhiGang Wang ◽  
...  
Keyword(s):  
Phase Transformation ◽  
Focused Ultrasound ◽  
Tumor Imaging ◽  
Low Intensity ◽  
Ultrasound Assisted

Effects of External Low Intensity Focused Ultrasound on Inflammatory Markers in Neuropathic Pain

2021 ◽  
pp. 135977
Author(s):  
Abigail Hellman ◽  
Alicia Clum ◽  
Teresa Maietta ◽  
Adithya Srikanthan ◽  
Vraj Patel ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Inflammatory Markers ◽  
Focused Ultrasound ◽  
Low Intensity

scholarly journals Extracellular vesicles: emerging targets for cancer therapy

2014 ◽  
Vol 20 (7) ◽  
pp. 385-393 ◽  
Author(s):  
Pieter Vader ◽  
Xandra O. Breakefield ◽  
Matthew J.A. Wood
Keyword(s):  
Cancer Therapy ◽  
Extracellular Vesicles

scholarly journals Noninvasive neuromodulation and thalamic mapping with low-intensity focused ultrasound

2018 ◽  
Vol 128 (3) ◽  
pp. 875-884 ◽  
Author(s):  
Robert F. Dallapiazza ◽  
Kelsie F. Timbie ◽  
Stephen Holmberg ◽  
Jeremy Gatesman ◽  
M. Beatriz Lopes ◽  
...  
Keyword(s):  
Focused Ultrasound ◽  
Thalamic Nucleus ◽  
Acoustic Energy ◽  
Similar Degree ◽  
Thalamic Nuclei ◽  
Low Intensity ◽  
Tissue Heating ◽  
The Central Nervous System ◽  
Selective Mapping ◽  
Noninvasive Neuromodulation

OBJECTIVEUltrasound can be precisely focused through the intact human skull to target deep regions of the brain for stereotactic ablations. Acoustic energy at much lower intensities is capable of both exciting and inhibiting neural tissues without causing tissue heating or damage. The objective of this study was to demonstrate the effects of low-intensity focused ultrasound (LIFU) for neuromodulation and selective mapping in the thalamus of a large-brain animal.METHODSTen Yorkshire swine (Sus scrofa domesticus) were used in this study. In the first neuromodulation experiment, the lemniscal sensory thalamus was stereotactically targeted with LIFU, and somatosensory evoked potentials (SSEPs) were monitored. In a second mapping experiment, the ventromedial and ventroposterolateral sensory thalamic nuclei were alternately targeted with LIFU, while both trigeminal and tibial evoked SSEPs were recorded. Temperature at the acoustic focus was assessed using MR thermography. At the end of the experiments, all tissues were assessed histologically for damage.RESULTSLIFU targeted to the ventroposterolateral thalamic nucleus suppressed SSEP amplitude to 71.6% ± 11.4% (mean ± SD) compared with baseline recordings. Second, we found a similar degree of inhibition with a high spatial resolution (∼ 2 mm) since adjacent thalamic nuclei could be selectively inhibited. The ventromedial thalamic nucleus could be inhibited without affecting the ventrolateral nucleus. During MR thermography imaging, there was no observed tissue heating during LIFU sonications and no histological evidence of tissue damage.CONCLUSIONSThese results suggest that LIFU can be safely used to modulate neuronal circuits in the central nervous system and that noninvasive brain mapping with focused ultrasound may be feasible in humans.

scholarly journals Circulating extracellular vesicles are effective biomarkers for predicting response to cancer therapy

EBioMedicine ◽  
2021 ◽  
Vol 67 ◽  
pp. 103365
Author(s):  
E Zhou ◽  
Yumei Li ◽  
Feng Wu ◽  
Mengfei Guo ◽  
Juanjuan Xu ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Extracellular Vesicles

Quantification of Displacement for Tactile Sensation in a Contact-type Low Intensity Focused Ultrasound Haptic Device

2020 ◽  
Vol 18 (1) ◽  
pp. 1-8
Author(s):  
Jeongbong Choi ◽  
Soonhyun Yook ◽  
In Young Kim ◽  
Mok Kun Jeong ◽  
Dong Pyo Jang
Keyword(s):  
Focused Ultrasound ◽  
Haptic Device ◽  
Tactile Sensation ◽  
Contact Type ◽  
Low Intensity

Modulating the Inflammatory Reflex in Rats Using Low-Intensity Focused Ultrasound Stimulation of the Vagus Nerve

2019 ◽  
Vol 45 (2) ◽  
pp. 481-489 ◽  
Author(s):  
Kelsey M. Wasilczuk ◽  
Kelsey C. Bayer ◽  
Jesse P. Somann ◽  
Gabriel O. Albors ◽  
Jennifer Sturgis ◽  
...  
Keyword(s):  
Vagus Nerve ◽  
Focused Ultrasound ◽  
Low Intensity ◽  
Ultrasound Stimulation ◽  
Stimulation Of
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