A pH-responsive dissociable mesoporous silica-based nanoplatform enabling efficient dual-drug co-delivery and rapid clearance for cancer therapy

2020 ◽  
Vol 8 (12) ◽  
pp. 3418-3429 ◽  
Author(s):  
Yongju He ◽  
Linjie Shao ◽  
Ibrahim Usman ◽  
Yao Hu ◽  
Anqiang Pan ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Epr Effect ◽  
Large Size ◽  
Rapid Clearance ◽  
Tumor Accumulation ◽  
Dual Drug

A pH-responsive dissociable mesoporous silica-based cluster with efficient dual-drug co-delivery for combinational cancer therapy, tumor accumulation via its large size-favored EPR effect and rapid clearance by its acid-triggered dissociation.

scholarly journals Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽  
2017 ◽  
Vol 8 (9) ◽  
pp. 1797-1805 ◽  
Author(s):  
Madhappan Santha Moorthy ◽  
Subramanian Bharathiraja ◽  
Panchanathan Manivasagan ◽  
Kang Dae Lee ◽  
Junghwan Oh
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

A combined “RAFT” and “Graft From” polymerization strategy for surface modification of mesoporous silica nanoparticles: towards enhanced tumor accumulation and cancer therapy efficacy

2014 ◽  
Vol 2 (35) ◽  
pp. 5828-5836 ◽  
Author(s):  
Ming Ma ◽  
Shuguang Zheng ◽  
Hangrong Chen ◽  
Minghua Yao ◽  
Kun Zhang ◽  
...  
Keyword(s):  
Surface Modification ◽  
Polyethylene Glycol ◽  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapy Efficacy ◽  
Tumor Accumulation

A novel modification route integrating the copolymers of positive charged quaternary amines and polyethylene glycol units using a combination “Raft” and “Graft From” strategy.

Acid Susceptible Ultrathin Mesoporous Silica Coated on Layered Double Hydroxide Nanoplates for pH Responsive Cancer Therapy

2018 ◽  
Vol 1 (3) ◽  
pp. 928-935 ◽  
Author(s):  
Wen Cao ◽  
Faheem Muhammad ◽  
Yuan Cheng ◽  
Min Zhou ◽  
Qian Wang ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Layered Double Hydroxide ◽  
Ph Responsive ◽  
Double Hydroxide
Sign in / Sign up

Export Citation Format

Share Document