Use of high resolution/accurate mass full scan/data-dependent acquisition for targeted/non-targeted screening in equine doping control

2021 ◽  
Vol 13 (13) ◽  
pp. 1565-1575
Author(s):  
Youwen You ◽  
Rachel M. Proctor ◽  
Kevin Guo ◽  
Xiaoqing Li ◽  
Evan Xue ◽  
...  
Keyword(s):  
High Resolution ◽  
Mass Spectrometer ◽  
Spectral Library ◽  
Screening Analysis ◽  
Orbitrap Mass Spectrometer ◽  
Targeted Screening ◽  
Compound Database ◽  
Full Scan ◽  
Scan Data ◽  
High Resolution Accurate Mass

A targeted/non-targeted LC-HRMS/MS method for equine doping screening analysis was developed using a QE-Plus Orbitrap mass spectrometer combined with an in-house built compound database and spectral library.

scholarly journals Non-targeted Screening of Commercial CBD Products in the United States Reveals Common Contamination and Adulteration

2020 ◽  
Author(s):  
Ben Orsburn
Keyword(s):  
United States ◽  
Mass Spectrometry ◽  
High Resolution ◽  
The United States ◽  
Mass Spectrometry Data ◽  
Accurate Mass ◽  
Targeted Screening ◽  
Accurate Mass Spectrometry ◽  
High Concentrations ◽  
High Resolution Accurate Mass

AbstractThe production of hemp and products derived from these plants that contain zero to trace amounts of the psychoactive cannabinoid tetrahydrocannabidiol (THC) is a rapidly growing new market in the United States. The most common products today contain relatively high concentrations of the compound cannabidiol (CBD). Recent studies have investigated commercial CBD products using targeted assays and have found varying degrees of misrepresentation and contamination of these products. To expand on previous studies, we demonstrate the application of non-targeted screening by high resolution accurate mass spectrometry to more comprehensively identify potential adulterants and contaminants. We find evidence to support previous conclusions that CBD products are commonly misrepresented in terms of cannabinoid concentrations present. Specifically, we observe a wide variation in relative THC concentrations across the product tested, with some products containing 10-fold more relative signal than others. In addition, we find that several products appear to be purposely adulterated with over the counter drugs such as caffeine and melatonin. We also observe multiple small molecule contaminants that are typically linked to improper production or packaging methods in food or pharmaceutical production. Finally, we present high resolution accurate mass spectrometry data and tandem MS/MS fragments supporting the presence of trace amounts of fluorofentanyl in a single mail order CBD product. We conclude that the CBD industry would benefit from more robust testing regulations and that the cannabis testing industry, in general, would benefit from the use of non-targeted screening technologies.

scholarly journals High-resolution extracted ion chromatography, a new tool for metabolomics and lipidomics using a second-generation orbitrap mass spectrometer

2009 ◽  
Vol 23 (10) ◽  
pp. 1411-1418 ◽  
Author(s):  
Albert Koulman ◽  
Gary Woffendin ◽  
Vinod K. Narayana ◽  
Helen Welchman ◽  
Catharina Crone ◽  
...  
Keyword(s):  
High Resolution ◽  
Mass Spectrometer ◽  
Ion Chromatography ◽  
Second Generation ◽  
Orbitrap Mass Spectrometer

Characterization of hydrocoptisonine metabolites in human liver microsomes using a high-resolution quadrupole-orbitrap mass spectrometer

Xenobiotica ◽  
2020 ◽  
Vol 50 (12) ◽  
pp. 1423-1433
Author(s):  
Su Min Choi ◽  
Younah Kim ◽  
Jaeick Lee ◽  
Ju-Hyun Kim ◽  
Taeho Lee ◽  
...  
Keyword(s):  
High Resolution ◽  
Mass Spectrometer ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Orbitrap Mass Spectrometer

High resolution/accurate mass (HRMS) detection of anatoxin-a in lake water using LDTD–APCI coupled to a Q-Exactive mass spectrometer

Talanta ◽  
2015 ◽  
Vol 132 ◽  
pp. 836-844 ◽  
Author(s):  
Audrey Roy-Lachapelle ◽  
Morgan Solliec ◽  
Marc Sinotte ◽  
Christian Deblois ◽  
Sébastien Sauvé
Keyword(s):  
High Resolution ◽  
Mass Spectrometer ◽  
Lake Water ◽  
Accurate Mass ◽  
Q Exactive ◽  
High Resolution Accurate Mass
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