CO2-effervescence assisted dispersive micro solid-phase extraction based on a magnetic layered double hydroxide modified with polyaniline and a surfactant for efficient pre-concentration of heavy metals in cosmetic samples

2020 ◽  
Vol 12 (40) ◽  
pp. 4867-4877
Author(s):  
Maryam Rajabi ◽  
Zohreh Mollakazemi ◽  
Maryam Hemmati ◽  
Somayeh Arghavani-Beydokhti

CO2-effervescence assisted dispersive micro solid-phase extraction procedure (CO2-EA-DμSPE) using a magnetic layered double hydroxide modified with polyaniline and a surfactant (Zn–Al–LDH–PA–DBSNa–Fe3O4) was applied for the pre-concentration of heavy metals.

1997 ◽  
Vol 43 (2) ◽  
pp. 312-325 ◽  
Author(s):  
Chi-Kong Lai ◽  
Ting Lee ◽  
Kam-Ming Au ◽  
Albert Yan-Wo Chan

Abstract In this HPLC–diode-array detection method for toxicological drug screening, a mixed-mode solid-phase extraction procedure is optimized for isolation of a broad range of drugs from serum and urine. Basic, neutral, and weakly acidic drugs are uniformly recovered. The extract from the solid-phase cartridge is readily injected to a reversed-phase HPLC column for separation by gradient elution. Unknown drugs and metabolites in urine and serum samples from acute drug poisoning cases are rapidly identified by matching their retention times and ultraviolet spectra with hundreds of reference compounds in the library. Urine metabolites of common toxicants from various medications and drugs of abuse are recorded, with their changes of retention times and ultraviolet spectra as related to their metabolic transformations. Glucuronide conjugates of common benzodiazepines, tricyclic antidepressants, and beta-blockers are examined directly without chemical or enzymatic hydrolysis. The system is reliable for diverse clinical investigations of drug overdoses, drug-induced psychoses, and substance abuse.


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