A simple and sensitive LC-MS/MS method for determination and quantification of potential genotoxic impurities in the ceritinib active pharmaceutical ingredient

Mia Antolčić; Mislav Runje; Nives Galić

doi:10.1039/d0ay00511h

A simple and sensitive LC-MS/MS method for determination and quantification of potential genotoxic impurities in the ceritinib active pharmaceutical ingredient

Analytical Methods ◽

10.1039/d0ay00511h ◽

2020 ◽

Vol 12 (25) ◽

pp. 3290-3295

Author(s):

Mia Antolčić ◽

Mislav Runje ◽

Nives Galić

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Active Pharmaceutical Ingredient ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Genotoxic Impurities ◽

Liquid Chromatography Tandem Mass

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for quantification of four potential genotoxic impurities (PGIs) in the ceritinib active pharmaceutical ingredient.

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Analysis of potential genotoxic impurities in rabeprazole active pharmaceutical ingredient via Liquid Chromatography-tandem Mass Spectrometry, following quality-by-design principles for method development

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2017.11.037 ◽

2018 ◽

Vol 149 ◽

pp. 410-418 ◽

Cited By ~ 9

Author(s):

Katerina Iliou ◽

Anđelija Malenović ◽

Yannis L. Loukas ◽

Yannis Dotsikas

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Method Development ◽

Quality By Design ◽

Active Pharmaceutical Ingredient ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Genotoxic Impurities ◽

Liquid Chromatography Tandem Mass

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Simultaneous Determination of Two Potential Genotoxic Impurities in Zolmitriptan Using Liquid Chromatography-Tandem Mass Spectrometry

Chemical Science Transactions ◽

10.7598/cst2014.732 ◽

2014 ◽

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Simultaneous Determination ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Genotoxic Impurities ◽

Liquid Chromatography Tandem Mass

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Identification and structural elucidation of an unknown impurity in carbamazepine active pharmaceutical ingredient by liquid chromatography–tandem mass spectrometry and semi-preparative chromatographic isolation

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2011.05.030 ◽

2011 ◽

Vol 56 (2) ◽

pp. 423-428 ◽

Cited By ~ 8

Author(s):

Saji Thomas ◽

Chandra S. Mathela ◽

Ashutosh Agarwal ◽

Saroj Kumar Paul

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Active Pharmaceutical Ingredient ◽

Structural Elucidation ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Chromatographic Isolation

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Development, validation and transfer into a factory environment of a liquid chromatography tandem mass spectrometry assay for the highly neurotoxic impurity FMTP (4-(4-fluorophenyl)-1-methyl-1,2,3,6-tetrahydropyridine) in paroxetine active pharmaceutical ingredient (API)

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2008.08.026 ◽

2008 ◽

Vol 48 (4) ◽

pp. 1082-1089 ◽

Cited By ~ 10

Author(s):

Phil J. Borman ◽

Marion J. Chatfield ◽

Elizabeth L. Crowley ◽

Christine Eckers ◽

David P. Elder ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Active Pharmaceutical Ingredient ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass ◽

Mass Spectrometry Assay

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Identification of the xanthone of the capitulae from Syngonatnhus nitens (Eriocaulaceae) by liquid chromatography tandem mass spectrometry

Planta Medica ◽

10.1055/s-0030-1264586 ◽

2010 ◽

Vol 76 (12) ◽

Author(s):

M Pacifico ◽

F Hilario ◽

A Napolitano ◽

C Pizza ◽

S Piacente ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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23 Liquid Chromatography/Tandem Mass Spectrometry (LC-MSMS) Analysis of neuropsychiatric drugs: Challenges from the perspective of the laboratory physician

10.1055/s-0040-1710131 ◽

2020 ◽

Author(s):

M Shipkova

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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199. Identification of a Major Human Metabolite of Acetochlor in Exposed Herbicide Applicators by High Performance Liquid Chromatography-Tandem Mass Spectrometry

10.3320/1.2758910 ◽

2006 ◽

Author(s):

C. Hines ◽

C. Striley ◽

D. Barr ◽

A. Olsson ◽

R. Bravo ◽

...

Keyword(s):

Mass Spectrometry ◽

High Performance Liquid Chromatography ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

High Performance ◽

Tandem Mass ◽

Human Metabolite ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Simultaneous determination of salivary androgens by liquid chromatography-tandem mass spectrometry: analytical and biological validation

Endocrine Abstracts ◽

10.1530/endoabs.35.p626 ◽

2014 ◽

Author(s):

Marco Mezzullo ◽

Flaminia Fanelli ◽

Elisa Dalla Benetta ◽

Silvia Garelli ◽

Alessandra Gambineri ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Simultaneous Determination ◽

Tandem Mass ◽

Biological Validation ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Cortisol measurement using immunoassay versus liquid chromatography-tandem mass spectrometry: metyrapone dose-related discrepancies in cortisol values

Endocrine Abstracts ◽

10.1530/endoabs.44.p80 ◽

2016 ◽

Author(s):

Christine H M Leong ◽

David R Taylor ◽

Benjamin C Whitelaw ◽

Simon Aylwin

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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Pharmacokinetics of Arctigenin in Rats by Using Liquid Chromatography-Tandem Mass Spectrometry

10.26226/morressier.57ea3d6ad462b8028d88e986 ◽

2016 ◽

Author(s):

SUBINDRA KAZI THAPA

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Tandem Mass Spectrometry ◽

Tandem Mass ◽

Chromatography Tandem Mass Spectrometry ◽

Liquid Chromatography Tandem Mass

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