Identification and structural elucidation of an unknown impurity in carbamazepine active pharmaceutical ingredient by liquid chromatography–tandem mass spectrometry and semi-preparative chromatographic isolation

2011 ◽  
Vol 56 (2) ◽  
pp. 423-428 ◽  
Author(s):  
Saji Thomas ◽  
Chandra S. Mathela ◽  
Ashutosh Agarwal ◽  
Saroj Kumar Paul
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Active Pharmaceutical Ingredient ◽  
Structural Elucidation ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Liquid Chromatography Tandem Mass ◽  
Chromatographic Isolation

A simple and sensitive LC-MS/MS method for determination and quantification of potential genotoxic impurities in the ceritinib active pharmaceutical ingredient

2020 ◽  
Vol 12 (25) ◽  
pp. 3290-3295
Author(s):  
Mia Antolčić ◽  
Mislav Runje ◽  
Nives Galić
Keyword(s):  
Mass Spectrometry ◽  
Liquid Chromatography ◽  
Tandem Mass Spectrometry ◽  
Active Pharmaceutical Ingredient ◽  
Tandem Mass ◽  
Chromatography Tandem Mass Spectrometry ◽  
Genotoxic Impurities ◽  
Liquid Chromatography Tandem Mass

A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was used for quantification of four potential genotoxic impurities (PGIs) in the ceritinib active pharmaceutical ingredient.

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