Electroanalytical profiling of cocaine samples by means of an electropolymerized molecularly imprinted polymer using benzocaine as the template molecule

The Analyst ◽  
2021 ◽  
Author(s):  
Renata A. Grothe ◽  
Alnilan Lobato ◽  
Bassim Mounssef ◽  
Nikola Tasić ◽  
Ataualpa A. C. Braga ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Chemometric Analysis ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Drug Traffic

Cocaine samples were ‘finger-printed’ using e-MIPs, constructed on the surface of portable SPCEs. The SWV data with suitable chemometric analysis provides valuable information about the drugs’ provenience which is crucial to tackle drug traffic.

scholarly journals Removal of bisphenol A from aqueous media using a highly selective adsorbent of hybridization cyclodextrin with magnetic molecularly imprinted polymer

2021 ◽  
Vol 8 (3) ◽  
Author(s):  
S. Mamman ◽  
F. B. M. Suah ◽  
M. Raaov ◽  
F. S. Mehamod ◽  
S. Asman ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Molecularly Imprinted Polymer ◽  
Binding Capacity ◽  
Bulk Polymerization ◽  
Resonance Spectroscopy ◽  
Template Molecule ◽  
Order Kinetic ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Magnetic Molecularly Imprinted Polymer

In this study, a unique magnetic molecularly imprinted polymer (MMIP) adsorbent towards bisphenol A (BPA) as a template molecule was developed by bulk polymerization using β-cyclodextrin (β-CD) as a co-monomer with methacrylic acid (MAA) to form MMIP MAA–βCD as a new adsorbent. β-CD was hybridized with MAA to obtain water-compactible imprinting sites for the effective removal of BPA from aqueous samples. Benzoyl peroxide and trimethylolpropane trimethacrylate were used as the initiator and cross-linker, respectively. The adsorbents were characterized by Fourier transform infrared spectroscopy, scanning electronic microscopy, transmission electron microscopy, vibrating sample magnetometer, Brunauer–Emmett–Teller and X-ray diffraction. 1 H nuclear magnetic resonance spectroscopy was used to characterize the MAA–βCD and BPA–MAA–βCD complex. Several parameters influencing the adsorption efficiency of BPA such as adsorbent dosage, pH of sample solution, contact time, initial concentrations and temperature as well as selectivity and reusability study have been evaluated. MMIP MAA–βCD showed significantly higher removal efficiency and selective binding capacity towards BPA compared to MMIP MAA owing to its unique morphology with the presence of β-CD. The kinetics data can be well described by the pseudo second-order kinetic and Freundlich isotherm and Halsey models best fitted the isotherm data. The thermodynamic studies indicated that the adsorption reaction was a spontaneous and exothermic process. Therefore, MMIP based on the hybrid monomer of MAA–βCD shows good potential of a new monomer in molecularly imprinted polymer preparation and can be used as an effective adsorbent for the removal of BPA from aqueous solutions.

Application of Response Surface Methodology to Synthesize Appropriate Molecularly Imprinted Polymer for Diazinon

2014 ◽  
Vol 605 ◽  
pp. 67-70 ◽  
Author(s):  
Mohsen Rahiminezhad ◽  
Seyed Jamaleddin Shahtaheri ◽  
Mohammad Reza Ganjali ◽  
Abbas Rahimi Rahimi Forushani
Keyword(s):  
Molecular Imprinting ◽  
Molecularly Imprinted Polymer ◽  
Binding Sites ◽  
Capillary Electrochromatography ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Molecular Imprinting Technology ◽  
Cross Linker

Molecular imprinting technology has become an interesting research area to the preparation of specific sorbent material for environmental and occupational sample preparation techniques (1). In the molecular imprinting technology, specific binding sites have been formed in polymeric matrix, which often have an affinity and selectivity similar to antibody-antigen systems (2). In molecular imprinted technology, functional monomers are arranged in a complementary configuration around a template molecule, then, cross-linker and solvent are also added and the mixture is treated to give a porous material containing nono-sized binding sites. After extraction of the template molecule by washing, vacant imprinted sites will be left in polymer, which are available for rebinding of the template or its structural analogue (3). The stability, convention of preparation and low cost of these materials make them particularly attractive (4). These synthetic materials have been used for capillary electrochromatography (5), chromatography columns (6), sensors (7), and catalyze system (8). Depending on the molecular imprinting approach, different experimental variables such as the type and amounts of functional monomers, porogenic solvent, initiator, monomer to cross-linker ratio, temperature, and etc may alter the properties of the final polymeric materials. In this work, chemometric approach based on Central Composite Design (CCD) was used to design the experiments as well as to find the optimum conditions for preparing appropriate diazinon molecularly imprinted polymer.

scholarly journals Redesigning an Electrochemical MIP Sensor for PFOS: Practicalities and Pitfalls

Sensors ◽  
2019 ◽  
Vol 19 (20) ◽  
pp. 4433 ◽  
Author(s):  
Giulia Moro ◽  
Davide Cristofori ◽  
Fabio Bottari ◽  
Elti Cattaruzza ◽  
Karolien De Wael ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Electrochemical Sensors ◽  
Differential Pulse ◽  
Complete Characterization ◽  
In Situ Monitoring ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Heterogeneous Distribution ◽  
Molecularly Imprinted ◽  
Mip Sensor

There is a growing interest in the technological transfer of highly performing electrochemical sensors within portable analytical devices for the in situ monitoring of environmental contaminants, such as perfluorooctanesulfonic acid (PFOS). In the redesign of biomimetic sensors, many parameters should be taken into account from the working conditions to the electrode surface roughness. A complete characterization of the surface modifiers can help to avoid time-consuming optimizations and better interpret the sensor responses. In the present study, a molecularly imprinted polymer electrochemical sensor (MIP) for PFOS optimized on gold disk electrodes was redesigned on commercial gold screen-printed electrodes. However, its performance investigated by differential pulse voltammetry was found to be poor. Before proceeding with further optimization, a morphological study of the bare and modified electrode surfaces was carried out by scanning electron microscopy–energy-dispersive X-ray spectrometry (SEM–EDS), atomic force microscopy (AFM) and profilometry revealing an heterogeneous distribution of the polymer strongly influenced by the electrode roughness. The high content of fluorine of the target-template molecule allowed to map the distribution of the molecularly imprinted polymer before the template removal and to define a characterization protocol. This case study shows the importance of a multi-analytical characterization approach and identify significant parameters to be considered in similar redesigning studies.

scholarly journals Potentiometric PVC-Membrane-Based Sensor for Dimethylamine Assessment Using A Molecularly Imprinted Polymer as A Sensory Recognition Element

Polymers ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 1695
Author(s):  
Saad S. M. Hassan ◽  
Abd El-Galil E. Amr ◽  
Heba Abd El-Naby ◽  
Mohamed A. Al-Omar ◽  
Ayman H. Kamel ◽  
...  
Keyword(s):  
Detection Limit ◽  
Molecularly Imprinted Polymer ◽  
Sampling Rate ◽  
Pvc Membrane ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
High Concentration ◽  
Buffer Solution ◽  
Molecularly Imprinted ◽  
Recognition Element

A new simple potentiometric sensor is developed and presented for sensitive and selective monitoring of dimethylamine (DMA). The sensor incorporates a molecularly imprinted polymer, with a pre-defined specific cavity suitable to accommodate DMA. The molecularly imprinted polymer (MIP) particles were dispersed in an aplasticized poly(vinyl chloride) matrix. The MIP is synthesized by using a template molecule (DMA), a functional monomer (acrylamide, AM), cross-linker (ethylene glycol dimethacrylate, EGDMA) and initiating reagent (benzoylperoxide, BPO). Using Trizma buffer solution (5 mmol L−1, pH 7.1), the sensor exhibits a rapid, stable and linear response for 1.0 × 10−5 to 1.0 × 10−2 mol L−1 DMA+ with a calibration slope of 51.3 ± 0.3 mV decade−1, and a detection limit of 4.6 × 10−6 mol L−1 (0.37 µg mL−1). The electrode exhibited a short response time (10 s) and stable potential readings (± 0.5 mV) for more than 2 months. Potentiometric selectivity measurements of the sensor reveal negligible interferences from most common aliphatic and aromatic amines. High concentration levels (100-fold excess) of many inorganic cations do not interfere. The sensor is successfully used for quantification of low levels of DMA down to 0.5 µg mL–1. Verification of the presented method was carried out after measuring the detection limit, working linearity range, ruggedness of the method, accuracy, precision, repeatability and reproducibility. Under flow-through conditions, the proposed sensor in its tubular form is prepared and introduced in a two-channel flow injection setup for hydrodynamic determination of DMA. The sampling rate is 50–55 samples h–1. The sensor is used to determine DMA in different soil samples with an accuracy range of 97.0–102.8%.

scholarly journals Phosphate Detection in Hydroponics using Molecularly Imprinted Polymer Sensors

2018 ◽  
Author(s):  
Christopher S. Storer ◽  
Zachary Coldrick ◽  
Daniel Tate ◽  
Jack Marsden Donoghue ◽  
Bruce Grieve
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Nutrient Sensing ◽  
Template Molecule ◽  
Functional Monomer ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Phosphate Nitrate ◽  
Lcr Meter ◽  
Phosphate Detection ◽  
Interference Study

An interdigitated electrode sensor was designed and microfabricated for measuring the changes in the capacitance of three phosphate selective molecularly imprinted polymer (MIP) formulations, in order to provide hydroponics users with a portable nutrient sensing tool. The MIPs investigated were synthesised using different combinations of the functional monomers methacrylic acid (MAA) and N-allylthiourea, against the template molecules diphenyl phosphate, triethyl phosphate and trimethyl phosphate. A cross-interference study between phosphate, nitrate and sulfate was carried out for the MIP materials using an inductance, capacitance and resistance (LCR) meter. Capacitance measurements were taken applying an alternating current (AC) with a potential difference of 1 V root mean square (RMS) at a frequency of 1 kHz. The cross-interference study demonstrated a strong binding preference to phosphate over the other nutrient salts tested for each formulation. The size of template molecule and length of the functional monomer side groups also determined that a combination of a short chain functional monomer in combination with a template containing large R-groups produced the optimal binding site conditions when synthesising a phosphate selective MIP.

scholarly journals Synergetic Effect of Dual Functional Monomers in Molecularly Imprinted Polymer Preparation for Selective Solid Phase Extraction of Ciprofloxacin

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2788
Author(s):  
Ut Dong Thach ◽  
Hong Hanh Nguyen Thi ◽  
Tuan Dung Pham ◽  
Hong Dao Mai ◽  
Tran-Thi Nhu-Trang
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymer ◽  
Solid Phase ◽  
Template Molecule ◽  
Phase Extraction ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Functional Monomers ◽  
Imprinted Polymers ◽  
Dual Functional

Background: Ciprofloxacin (CIP), an important broad-spectrum fluoroquinolone antibiotic, was often used as a template molecule for the preparation of imprinted materials. In this study, methacrylic acid and 2-vinylpyridine were employed for the first time as dual functional monomers for synthesizing ciprofloxacin imprinted polymers. Methods: The chemical and physicochemical properties of synthesized polymers were characterized using Fourier transform-infrared spectroscopy, thermogravimetric analysis-differential scanning calorimetry, scanning electron microscopy, and nitrogen adsorption-desorption isotherm. The adsorption properties of ciprofloxacin onto synthesized polymers were determined by batch experiments. The extraction performances were studied using the solid phase extraction and HPCL-UV method. Results: The molecularly imprinted polymer synthesized with dual functional monomers showed a higher adsorption capacity and selectivity toward the template molecule. The adsorbed amounts of ciprofloxacin onto the imprinted and non-imprinted polymer were 2.40 and 1.45 mg g−1, respectively. Furthermore, the imprinted polymers were employed as a selective adsorbent for the solid phase extraction of ciprofloxacin in aqueous solutions with the recovery of 105% and relative standard deviation of 7.9%. This work provides an alternative approach for designing a new adsorbent with high adsorption capacity and good extraction performance for highly polar template molecules.

Molecularly Imprinted Polymer Nanoparticles for Selective Solid Phase Extraction of Fluvoxamine in Human Urine and Plasma

2019 ◽  
Vol 58 (3) ◽  
pp. 274-279
Author(s):  
Mojtaba Soleimani ◽  
Ameneh Porgham Daryasari ◽  
Parisa Joshani
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Dynamic Range ◽  
Solid Phase ◽  
Polymer Nanoparticles ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Molecularly Imprinted ◽  
Selective Determination ◽  
Ft Ir

Abstract In this work, the molecularly imprinted polymer nanoparticles (MIP-NPs) for the selective determination of fluvoxamine have been described. The polymer nanoparticles were synthesized by the polymerization of methacrylic acid as a functional monomer, ethylene glycol dimethacrylate as a cross-linker, 2,2-azobisisobutyronitrile as an initiator and fluvoxamine as a template molecule. The MIP-NPs were characterized using techniques that included Fourier transform infrared (FT-IR) spectroscopy and scanning electron microscopy (SEM). Imprinted fluvoxamine molecules were removed from the polymeric structure using acetonitrile in methanol (2:8; v/v) as the eluting solvent. The linear dynamic range for fluvoxamine was 10–1200 μg L−1. The developed method was successfully applied to the extraction of fluvoxamine in complex biological samples.

scholarly journals A Novel Method for Extraction of Galegine by Molecularly Imprinted Polymer (MIP) Technique Reinforced with Graphene Oxide and Its Evaluation Using Polarography

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
M. Azimi ◽  
M. Ahmadi Golsefidi ◽  
A. Varasteh Moradi ◽  
M. Ebadii ◽  
R. Zafar Mehrabian
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Limit Of Detection ◽  
Diabetes Type 2 ◽  
Differential Pulse ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Limit Of Quantification ◽  
Molecularly Imprinted ◽  
Galega Officinalis ◽  
Relative Standard

Galega officinalis products have been used for the control of diabetes (type 2) across the world. Experimental and clinical evaluations of galegine substance produced by a medicinal plant (Galega officinalis) provided the pharmacological and chemical basis for metformin discovery which was confirmed for diabetes therapy. In this paper, the molecularly imprinted polymer (MIP) was synthesized for galegine, using galegine as a template molecule, methacrylic acid (MAA) as a functional monomer, ethylene glycol dimethacrylate (EGDMA) as a cross-linker, azobisisobutyronitrile (AIBN) as a reaction initiator, and acetonitrile as a solvent. The assisted functional groups, morphology, topographic image of surface, and crystalline structure of synthesized MIP were characterized by FT-IR spectroscopy, field emission scanning electron microscopy (FE-SEM), atomic force microscopy (AFM) images, and XRD diffraction pattern techniques, respectively. Also, the performance of the mentioned electrode was quantified and qualified by the differential pulse voltammetry technique (DPV). The galegine amount was determined with the polarographic technique. In this research, the galegine extraction conditions were optimized and graphene nanoparticles were used to increase the adsorption. In addition, different parameters affecting extraction were investigated such as MIP adsorbent amount, pH of solution, effect of the surfactant, and ionic compound to achieve high recovery percent. The recovery percent, limit of detection (LOD), limit of quantification (LOQ), and relative standard deviation (RSD %) were 4.101 μg·mL−1, 12.427 μg·mL−1, and 1.199% (n = 3), respectively. The results show that the prepared MIP can be used as an effective and inexpensive adsorbent for preconcentration and galegine extraction from a natural sample. It is noteworthy that this developed method was used successfully to determine galegine extracted from Galega officinalis L.

Microfluidic Synthesis and Functional Patterning for Advanced Nanotechnology

2010 ◽  
Vol 1260 ◽  
Author(s):  
Kyung Choi
Keyword(s):  
Molecularly Imprinted Polymer ◽  
Chemical Sensors ◽  
Binding Sites ◽  
Template Molecule ◽  
Imprinted Polymer ◽  
Comparative Result ◽  
Molecularly Imprinted ◽  
Optically Transparent

AbstractIn this study, we introduce ‘molecularly imprinted polymer' (MIP) system, which has receptor or binding sites with specific molecular recognitions.Due to the receptor or binding sites in MIP's systems, it can be used for developing bio- or chemical sensors.To fabricate bio-sensors, bio-molecules have been incorporated into MIP's systems as template molecules, but some bio-molecules are sensitive thus denatured during engineering processes.For this reason, bio-sensor fabrications by conventional UV photolithography have shown some limitations.We demonstrate here a photopatterning process, a micromolding in capillary technique (MIMIC) technique, to photopatterning a MIP's system containing a bio-molecule template.The MIMIC technique uses the photo-masks for photopolymerizing MIP's monomer solutions.The photomask is based on silicon rubbers, which are optically transparent and also minimize any damages of sensitive bio-molecules during photo-polymerizations. For visualizing lithographic performances of MIP's systems, we used a fluorescent template molecule to present a comparative result of MIP's photo-cured patterns.It shows a clear different in MIP's patterns with and without the template.We also employed a microfluidic approach to produce micro-sized MIP's particles, which contribute to increase the sensitivity of bio-molecule sensors/devices.

Sign in / Sign up

Export Citation Format

Share Document