Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical staining

The Analyst ◽  
2021 ◽  
Author(s):  
Ibrahim Kaya ◽  
Eva Jennische ◽  
Stefan Lange ◽  
Per Malmberg
Keyword(s):  
Mass Spectrometry ◽  
Brain Tissue ◽  
Tissue Section ◽  
Imaging Mass Spectrometry ◽  
Chemical Imaging ◽  
Histochemical Staining ◽  
Maldi Tof ◽  
Tof Sims ◽  
Brain Tissue Section

ToF-SIMS and/or MALDI-ToF imaging mass spectrometry of a single brain tissue section followed by classical- or immuno- histochemical staining.

Methods for Human Olfactory Bulb Tissue Studies Using Peptide/Protein MALDI-TOF Imaging Mass Spectrometry (MALDI-IMS)

2017 ◽  
pp. 91-106 ◽  
Author(s):  
Ibon Iloro ◽  
Joaquín Fernández-Irigoyen ◽  
Iraide Escobes ◽  
Mikel Azkargorta ◽  
Enrique Santamaría ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Olfactory Bulb ◽  
Imaging Mass Spectrometry ◽  
Maldi Tof ◽  
Maldi Ims

Imaging mass spectrometry of gold nanoparticles in a tissue section as an immunohistochemical staining mass probe

2018 ◽  
Vol 54 (1) ◽  
pp. 1-6 ◽  
Author(s):  
Daiki Muko ◽  
Takanori Ikenaga ◽  
Masanori Kasai ◽  
Janice B. Rabor ◽  
Atsushi Nishitani ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gold Nanoparticles ◽  
Tissue Section ◽  
Immunohistochemical Staining ◽  
Imaging Mass Spectrometry

Cell and Tissue Imaging by TOF-SIMS and MALDI-TOF: An Overview for Biological and Pharmaceutical Analysis

2021 ◽  
pp. 1-26
Author(s):  
Manale Noun ◽  
Rayane Akoumeh ◽  
Imane Abbas
Keyword(s):  
Mass Spectrometry ◽  
Spatial Distribution ◽  
Time Of Flight ◽  
Molecular Ions ◽  
Tissue Imaging ◽  
Diagnostic Tools ◽  
Good Precision ◽  
Maldi Tof ◽  
Tof Sims ◽  
Wide Range

Abstract The potential of mass spectrometry imaging (MSI) has been demonstrated in cell and tissue research since 1970. MSI can reveal the spatial distribution of a wide range of atomic and molecular ions detected from biological sample surfaces, it is a powerful and valuable technique used to monitor and detect diverse chemical and biological compounds, such as drugs, lipids, proteins, and DNA. MSI techniques, notably matrix-assisted laser desorption/ionization time of flight (MALDI-TOF) and time of flight secondary ion mass spectrometry (TOF-SIMS), witnessed a dramatic upsurge in studying and investigating biological samples especially, cells and tissue sections. This advancement is attributed to the submicron lateral resolution, the high sensitivity, the good precision, and the accurate chemical specificity, which make these techniques suitable for decoding and understanding complex mechanisms of certain diseases, as well as monitoring the spatial distribution of specific elements, and compounds. While the application of both techniques for the analysis of cells and tissues is thoroughly discussed, a briefing of MALDI-TOF and TOF-SIMS basis and the adequate sampling before analysis are briefly covered. The importance of MALDI-TOF and TOF-SIMS as diagnostic tools and robust analytical techniques in the medicinal, pharmaceutical, and toxicology fields is highlighted through representative published studies.

scholarly journals Identification of nanoparticles and their localization in algal biofilm by 3D-imaging secondary ion mass spectrometry

2019 ◽  
Vol 34 (6) ◽  
pp. 1098-1108 ◽  
Author(s):  
Pietro Benettoni ◽  
Hryhoriy Stryhanyuk ◽  
Stephan Wagner ◽  
Felix Kollmer ◽  
Jairo H. Moreno Osorio ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
3D Imaging ◽  
Secondary Ion Mass Spectrometry ◽  
Biological Systems ◽  
Chemical Imaging ◽  
Resolving Power ◽  
Tof Sims ◽  
Mass Resolving Power ◽  
Algal Biofilm ◽  
Secondary Ion

ToF-SIMS boundaries were pushed to enhance lateral resolution and mass resolving power for chemical imaging of nanoparticles in biological systems.

Preliminary studies using imaging mass spectrometry TOF-SIMS in detection and analysis of fingerprints

2007 ◽  
Vol 55 (3) ◽  
pp. 180-187 ◽  
Author(s):  
M I Szynkowska ◽  
K Czerski ◽  
J Grams ◽  
T Paryjczak ◽  
A Parczewski
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Tof Sims
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