Novel D–π-A type near-infrared fluorescent probes for the detection of Aβ40 aggregates

The Analyst ◽  
2020 ◽  
Vol 145 (20) ◽  
pp. 6579-6585
Author(s):  
Guanglei Lv ◽  
Yunze Xu ◽  
Jiajia Yang ◽  
Wenhui Li ◽  
Chunxia Li ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Transgenic Mouse Models ◽  
The Brain

A NIR fluorescent probe was synthesized for the preferential detection of Aβ40 aggregates in solution and the brain sections of AD transgenic mouse models.

scholarly journals Near Infrared Light Treatment Reduces Synaptic Levels of Toxic Tau Oligomers in Two Transgenic Mouse Models of Human Tauopathies

2018 ◽  
Vol 56 (5) ◽  
pp. 3341-3355 ◽  
Author(s):  
Michele M. Comerota ◽  
Batbayar Tumurbaatar ◽  
Balaji Krishnan ◽  
Rakez Kayed ◽  
Giulio Taglialatela
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Light Treatment ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light ◽  
Tau Oligomers

P1-058: Different effects of L-(-)-nicotine on beta-amyloid pathology in the brain of two transgenic mouse models

2006 ◽  
Vol 2 ◽  
pp. S111-S112
Author(s):  
Monika M. Hedberg ◽  
Marie M. Svedberg ◽  
Tamanna Mustafiz ◽  
Christina Unger ◽  
Agneta Nordberg
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Beta Amyloid ◽  
Transgenic Mouse Models ◽  
Amyloid Pathology ◽  
The Brain

Near infrared light mitigates cerebellar pathology in transgenic mouse models of dementia

2015 ◽  
Vol 591 ◽  
pp. 155-159 ◽  
Author(s):  
Sivaraman Purushothuman ◽  
Daniel M. Johnstone ◽  
Charith Nandasena ◽  
Janet van Eersel ◽  
Lars M. Ittner ◽  
...  
Keyword(s):  
Transgenic Mouse ◽  
Mouse Models ◽  
Near Infrared ◽  
Infrared Light ◽  
Transgenic Mouse Models ◽  
Near Infrared Light

scholarly journals Validation of Fucoxanthin from Microalgae Phaeodactylum tricornutum for the Detection of Amyloid Burden in Transgenic Mouse Models of Alzheimer’s Disease

2021 ◽  
Vol 11 (13) ◽  
pp. 5878
Author(s):  
A-Hyeon Lee ◽  
Sung-Chul Hong ◽  
Inwook Park ◽  
Soljee Yoon ◽  
YoungSoo Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mouse ◽  
Mouse Models ◽  
Phaeodactylum Tricornutum ◽  
Fluorescent Imaging ◽  
Transgenic Mouse Models ◽  
Fluorescent Substance ◽  
Aβ Aggregation ◽  
The Brain

The visualization of misfolded Aβ peptides by using fluorescence chemical dyes is very important in Alzheimer’s disease (AD) diagnosis. Here, we describe the fluorescent substance, fucoxanthin, which detects Aβ aggregates in the brain of AD transgenic mouse models. We found that fucoxanthin from the microalgae Phaeodactylum tricornutum has fluorescent excitation and emission wavelengths without any interference for Aβ interaction. Thus, we applied it to monitor Aβ aggregation in AD transgenic mouse models. Aβ plaques were visualized using fucoxanthin in the brain tissue of APP/PS1 and 5×FAD mice by histological staining with different staining methods. By comparing fucoxanthin-positive and thioflavin S-positive stained regions in the brains, we found that they are colocalized and that fucoxanthin can detect Aβ aggregates. Our finding suggests that fucoxanthin from P. tricornutum can be a new Aβ fluorescent imaging reagent in AD diagnosis.

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