scholarly journals A new method to amplify colorimetric signals of paper-based nanobiosensors for simple and sensitive pancreatic cancer biomarker detection

The Analyst ◽  
2020 ◽  
Vol 145 (15) ◽  
pp. 5113-5117 ◽  
Author(s):  
K. Sudhakara Prasad ◽  
Yousef Abugalyon ◽  
Chunqiang Li ◽  
Feng Xu ◽  
XiuJun Li
Keyword(s):  
Pancreatic Cancer ◽  
Gold Nanoparticles ◽  
Catalytic Properties ◽  
Dye Degradation ◽  
Low Cost ◽  
Colorimetric Detection ◽  
Cancer Biomarker ◽  
New Method ◽  
Biomarker Detection

Catalytic properties of gold nanoparticles in colour dye degradation are utilized to amplify colorimetric detection signals of a low-cost paper-based immunosensor for instrument-free detection of pancreatic cancer biomarker PEAK1.

scholarly journals Enhancement of the Peroxidase-Like Activity of Iodine-Capped Gold Nanoparticles for the Colorimetric Detection of Biothiols

Biosensors ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 113 ◽  
Author(s):  
Chia-Chen Chang ◽  
Tsz-Lian Hsu ◽  
Chie-Pein Chen ◽  
Chen-Yu Chen
Keyword(s):  
Gold Nanoparticles ◽  
Catalytic Activity ◽  
Detection Limit ◽  
Enzymatic Activity ◽  
Catalytic Properties ◽  
Colorimetric Assay ◽  
Colorimetric Detection ◽  
Synergetic Effect ◽  
Vis Spectroscopy ◽  
Wide Range

A colorimetric assay was developed for the detection of biothiols, based on the peroxidase-like activity of iodine-capped gold nanoparticles (AuNPs). These AuNPs show a synergetic effect in the form of peroxidase-mimicking activity at the interface of AuNPs, while free AuNPs and iodine alone have weak catalytic properties. Thus, iodine-capped AuNPs possess good intrinsic enzymatic activity and trigger the oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB), leading to a change in color from colorless to yellow. When added to solution, biothiols, such as cysteine, strongly bind to the interface of AuNPs via gold-thiol bonds, inhibiting the catalytic activity of AuNPs, resulting in a decrease in oxidized TMB. Using this strategy, cysteine could be linearly determined, at a wide range of concentrations (0.5 to 20 μM), with a detection limit of 0.5 μM using UV-Vis spectroscopy. This method was applied for the detection of cysteine in diluted human urine.

Ultrasensitive colorimetric detection of Hg2+ ions based on enhanced catalytic performance of gold amalgam dispersed in channels of rose petals

The Analyst ◽  
2019 ◽  
Vol 144 (4) ◽  
pp. 1205-1209 ◽  
Author(s):  
Chi Zhang ◽  
Caiyun Kong ◽  
Qingyun Liu ◽  
Zhengbo Chen
Keyword(s):  
Gold Nanoparticles ◽  
Pore Structure ◽  
Low Cost ◽  
Colorimetric Detection ◽  
Catalytic Performance ◽  
Mercury Ions ◽  
Colorimetric Sensing ◽  
Rose Petals

We herein present a simple, low-cost, and ultrasensitive colorimetric sensing strategy for the detection of mercury ions (Hg2+) that takes advantage of the natural pore structure in rose petals to encapsulate gold nanoparticles (AuNPs).

Colorimetric detection of quaternary ammonium surfactants using citrate-stabilized gold nanoparticles (Au NPs)

2014 ◽  
Vol 6 (7) ◽  
pp. 2031-2033 ◽  
Author(s):  
Li-Qing Zheng ◽  
Xiao-Dong Yu ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen
Keyword(s):  
Gold Nanoparticles ◽  
Quaternary Ammonium ◽  
Low Cost ◽  
Colorimetric Detection ◽  
Hydrophobic Effect ◽  
Colorimetric Method ◽  
Au Nps ◽  
Quaternary Ammonium Surfactants

Based on the hydrophobic effect inducing the aggregation of Au NPs, a rapid and low-cost colorimetric method for detection of quaternary ammonium surfactants using citrate-stabilized AuNPs was developed.

scholarly journals Highly Sensitive and Selective Colorimetric Detection of Methylmercury Based on DNA Functionalized Gold Nanoparticles

Sensors ◽  
2018 ◽  
Vol 18 (8) ◽  
pp. 2679 ◽  
Author(s):  
Zheng-Jun Xie ◽  
Xian-Yu Bao ◽  
Chi-Fang Peng
Keyword(s):  
Gold Nanoparticles ◽  
Catalytic Activity ◽  
Limit Of Detection ◽  
Low Cost ◽  
Colorimetric Detection ◽  
Colorimetric Method ◽  
Optimal Conditions ◽  
Surface Deposition ◽  
Highly Sensitive ◽  
Dna Strand

A new colorimetric detection of methylmercury (CH3Hg+) was developed, which was based on the surface deposition of Hg enhancing the catalytic activity of gold nanoparticles (AuNPs). The AuNPs were functionalized with a specific DNA strand (HT7) recognizing CH3Hg+, which was used to capture and separate CH3Hg+ by centrifugation. It was found that the CH3Hg+ reduction resulted in the deposition of Hg onto the surface of AuNPs. As a result, the catalytic activity of the AuNPs toward the chromogenic reaction of 3,3,5,5-tetramethylbenzidine (TMB)-H2O2 was remarkably enhanced. Under optimal conditions, a limit of detection of 5.0 nM was obtained for CH3Hg+ with a linear range of 10–200 nM. We demonstrated that the colorimetric method was fairly simple with a low cost and can be conveniently applied to CH3Hg+ detection in environmental samples.

scholarly journals Pancreatic cancer biomarker detection by two support vector strategies for recursive feature elimination

2019 ◽  
Vol 13 (2) ◽  
pp. 105-121 ◽  
Author(s):  
Yan Wang ◽  
Keke Liu ◽  
Qin Ma ◽  
Yongfei Tan ◽  
Wei Du ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Biomarker ◽  
Recursive Feature Elimination ◽  
Support Vector ◽  
Biomarker Detection

Improved breast cancer biomarker detection through a simple, high frequency, low cost external proficiency testing program

Pathology ◽  
2010 ◽  
Vol 42 (7) ◽  
pp. 637-642 ◽  
Author(s):  
Tawny Hung ◽  
Robert Wolber ◽  
John Garratt ◽  
Steven Kalloger ◽  
C. Blake Gilks
Keyword(s):  
Breast Cancer ◽  
Proficiency Testing ◽  
High Frequency ◽  
Low Cost ◽  
Cancer Biomarker ◽  
Biomarker Detection ◽  
Testing Program

scholarly journals Multiplex Targeted Proteomic Assay for Biomarker Detection in Plasma: A Pancreatic Cancer Biomarker Case Study

2012 ◽  
Vol 11 (3) ◽  
pp. 1937-1948 ◽  
Author(s):  
Sheng Pan ◽  
Ru Chen ◽  
Randall E. Brand ◽  
Sarah Hawley ◽  
Yasuko Tamura ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Biomarker ◽  
Biomarker Detection

Preparation of gold nanoparticles using pyridine-formaldehyde as a reducing agent and its application in high sensitivity colorimetric detection of Pb2+

2019 ◽  
Vol 11 (34) ◽  
pp. 4362-4369 ◽  
Author(s):  
Liling Lei ◽  
Haimei Song ◽  
Junhong Zhao ◽  
Qingxiang Yang ◽  
Zhijun Chen
Keyword(s):  
Gold Nanoparticles ◽  
Aqueous Solutions ◽  
Colorimetric Detection ◽  
High Sensitivity ◽  
Colorimetric Sensor ◽  
Reducing Agent ◽  
New Method

A new method for preparing AuNPs has been successfully developed by using pyridine-formaldehyde as reducing agent. The AuNPs were used in colorimetric sensor for detection of Pb2+ in aqueous solutions.

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