Evaluating biochemical differences in thyroglobulin from normal and goiter tissues by infrared spectral imaging

The Analyst ◽  
2020 ◽  
Vol 145 (24) ◽  
pp. 7907-7915
Author(s):  
Thiago Martini Pereira ◽  
Max Diem ◽  
Luciano Bachmann ◽  
Benjamin Bird ◽  
Milos Miljković ◽  
...  
Keyword(s):  
Spectral Imaging ◽  
Follicular Cells ◽  
Thyroid Follicular Cells ◽  
Infrared Spectral

Thyroglobulin is a glycoiodoprotein that is produced by thyroid follicular cells; it is stored in follicles in structures known as colloids.

Identification and source attribution of halocarbon emitters with longwave-infrared spectral imaging

2021 ◽  
Vol 258 ◽  
pp. 112398
Author(s):  
David M. Tratt ◽  
Kerry N. Buckland ◽  
Eric R. Keim ◽  
Jeffrey L. Hall
Keyword(s):  
Spectral Imaging ◽  
Source Attribution ◽  
Infrared Spectral

scholarly journals Overexpression of Metallothionein I/II: A New Feature of Thyroid Follicular Cells in Graves' Disease

2012 ◽  
Vol 97 (2) ◽  
pp. 446-454 ◽  
Author(s):  
M. Ruiz-Riol ◽  
M. J. Martínez-Arconada ◽  
N. Alonso ◽  
B. Soldevila ◽  
D. Marchena ◽  
...  
Keyword(s):  
Graves Disease ◽  
Follicular Cells ◽  
Thyroid Follicular Cells ◽  
New Feature

Research on method of infrared spectral imaging based on thermal imager

2011 ◽  
Author(s):  
Ke-wei Huan ◽  
Xiao-guang Shi ◽  
Wei Wu ◽  
Feng Zheng ◽  
Xiao-xi Liu
Keyword(s):  
Spectral Imaging ◽  
Thermal Imager ◽  
Infrared Spectral

scholarly journals Notch Signaling Is Involved in Expression of Thyrocyte Differentiation Markers and Is Down-Regulated in Thyroid Tumors

2008 ◽  
Vol 93 (10) ◽  
pp. 4080-4087 ◽  
Author(s):  
E. Ferretti ◽  
E. Tosi ◽  
A. Po ◽  
A. Scipioni ◽  
R. Morisi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thyroid Cancer ◽  
Notch Signaling ◽  
Notch Pathway ◽  
Human Thyroid ◽  
Thyroid Tumors ◽  
Follicular Cells ◽  
Differentiation Markers ◽  
Thyroid Follicular Cells ◽  
Thyroid Cancer Cells

Context: Notch genes encode receptors for a signaling pathway that regulates cell growth and differentiation in various contexts, but the role of Notch signaling in thyroid follicular cells has never been fully published. Objective: The objective of the study was to characterize the expression of Notch pathway components in thyroid follicular cells and Notch signaling activities in normal and transformed thyrocytes. Design/Setting and Patients: Expression of Notch pathway components and key markers of thyrocyte differentiation was analyzed in murine and human thyroid tissues (normal and tumoral) by quantitative RT-PCR and immunohistochemistry. The effects of Notch overexpression in human thyroid cancer cells and FTRL-5 cells were explored with analysis of gene expression, proliferation assays, and experiments involving transfection of a luciferase reporter construct containing human NIS promoter regions. Results: Notch receptors are expressed during the development of murine thyrocytes, and their expression levels parallel those of thyroid differentiation markers. Notch signaling characterized also normal adult thyrocytes and is regulated by TSH. Notch pathway components are variably expressed in human normal thyroid tissue and thyroid tumors, but expression levels are clearly reduced in undifferentiated tumors. Overexpression of Notch-1 in thyroid cancer cells restores differentiation, reduces cell growth rates, and stimulates NIS expression via a direct action on the NIS promoter. Conclusion: Notch signaling is involved in the determination of thyroid cell fate and is a direct regulator of thyroid-specific gene expression. Its deregulation may contribute to the loss of differentiation associated with thyroid tumorigenesis.

scholarly journals Tie-2 Is Expressed on Thyroid Follicular Cells, Is Increased in Goiter, and Is Regulated by Thyrotropin through Cyclic Adenosine 3′,5′-Monophosphate1

2001 ◽  
Vol 86 (6) ◽  
pp. 2709-2716 ◽  
Author(s):  
James D. Ramsden ◽  
Helen C. Cocks ◽  
Munjiba Shams ◽  
Sarbjit Nijjar ◽  
John C. Watkinson ◽  
...  
Keyword(s):  
Follicular Cells ◽  
Thyroid Follicular Cells

scholarly journals Planning of 131I Therapy for Graves Disease Based on the Radiation Dose to Thyroid Follicular Cells

2008 ◽  
Vol 49 (12) ◽  
pp. 2026-2030 ◽  
Author(s):  
D. Eterovic ◽  
Z. Antunovic ◽  
V. Markovic ◽  
D. Grosev
Keyword(s):  
Radiation Dose ◽  
131I Therapy ◽  
Graves Disease ◽  
Follicular Cells ◽  
Thyroid Follicular Cells
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