Microfluidic device fabrication mediated by surface chemical bonding

The Analyst ◽  
2020 ◽  
Vol 145 (12) ◽  
pp. 4096-4110 ◽  
Author(s):  
Rajamanickam Sivakumar ◽  
Nae Yoon Lee
Keyword(s):  
Microfluidic Device ◽  
Chemical Bonding ◽  
Atmospheric Pressure ◽  
Room Temperature ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Surface Chemical

This review discusses on various bonding techniques for fabricating microdevices with a special emphasis on the modification of surface assisted by the use of chemicals to assemble microfluidic devices at room temperature under atmospheric pressure.

scholarly journals Three-Dimensional Printing Based Hybrid Manufacturing of Microfluidic Devices

2015 ◽  
Vol 6 (2) ◽  
Author(s):  
Yunus Alapan ◽  
Muhammad Noman Hasan ◽  
Richang Shen ◽  
Umut A. Gurkan
Keyword(s):  
3D Printing ◽  
Microfluidic Device ◽  
High Surface ◽  
Three Dimensional ◽  
Microfluidic Devices ◽  
Single Step ◽  
Device Fabrication ◽  
Hybrid Manufacturing ◽  
Fabrication Method ◽  
Design Complexity

Microfluidic platforms offer revolutionary and practical solutions to challenging problems in biology and medicine. Even though traditional micro/nanofabrication technologies expedited the emergence of the microfluidics field, recent advances in advanced additive manufacturing hold significant potential for single-step, stand-alone microfluidic device fabrication. One such technology, which holds a significant promise for next generation microsystem fabrication is three-dimensional (3D) printing. Presently, building 3D printed stand-alone microfluidic devices with fully embedded microchannels for applications in biology and medicine has the following challenges: (i) limitations in achievable design complexity, (ii) need for a wider variety of transparent materials, (iii) limited z-resolution, (iv) absence of extremely smooth surface finish, and (v) limitations in precision fabrication of hollow and void sections with extremely high surface area to volume ratio. We developed a new way to fabricate stand-alone microfluidic devices with integrated manifolds and embedded microchannels by utilizing a 3D printing and laser micromachined lamination based hybrid manufacturing approach. In this new fabrication method, we exploit the minimized fabrication steps enabled by 3D printing, and reduced assembly complexities facilitated by laser micromachined lamination method. The new hybrid fabrication method enables key features for advanced microfluidic system architecture: (i) increased design complexity in 3D, (ii) improved control over microflow behavior in all three directions and in multiple layers, (iii) transverse multilayer flow and precisely integrated flow distribution, and (iv) enhanced transparency for high resolution imaging and analysis. Hybrid manufacturing approaches hold great potential in advancing microfluidic device fabrication in terms of standardization, fast production, and user-independent manufacturing.

scholarly journals A rapid-prototyped moulding system towards optimised scalable fabrication of elastomeric microfluidic devices

2021 ◽  
Author(s):  
Christine Poon ◽  
Albert Fahrenbach
Keyword(s):  
3D Printing ◽  
Microfluidic Device ◽  
Lean Manufacturing ◽  
Soft Lithography ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Petri Dish ◽  
Device Fabrication ◽  
Alternative Techniques ◽  
Optimisation Techniques

3D printing and makerspace technologies are increasingly explored as alternative techniques to soft lithography for making microfluidic devices, and for their potential to segue towards scalable commercial fabrication. Here we considered the optimal application of current benchtop 3D printing for microfluidic device fabrication through the lens of lean manufacturing and present a straightforward but robust rapid prototyped moulding system that enables easy estimation of more precise quantities of polydimethylsiloxane (PDMS) required per device to reduce waste and importantly, making devices with better defined depths and volumes for (i) modelling gas exchange and (ii) fabrication consistency as required for quality-controlled production. We demonstrate that this low-cost moulding step can enable a 40 – 300% reduction in the amount of PDMS required for making individual devices compared to the established method of curing approximately 30 grams of PDMS prepolymer overlaid on a 4” silicon wafer master in a standard plastic petri dish. Other process optimisation techniques were also investigated and are recommended as readily implementable changes to current laboratory and foundry-level microfluidic device fabrication protocols for making devices either out of PDMS or other elastomers. Simple calculators are provided as a step towards more streamlined, software controlled and automated design-to-fabrication workflows for both custom and scalable lean manufacturing of microfluidic devices.

scholarly journals A Review of Current Methods in Microfluidic Device Fabrication and Future Commercialization Prospects

Inventions ◽  
2018 ◽  
Vol 3 (3) ◽  
pp. 60 ◽  
Author(s):  
Bruce Gale ◽  
Alexander Jafek ◽  
Christopher Lambert ◽  
Brady Goenner ◽  
Hossein Moghimifam ◽  
...  
Keyword(s):  
High Resolution ◽  
3D Printing ◽  
Microfluidic Device ◽  
Microfluidic Devices ◽  
Device Fabrication ◽  
Costs And Benefits ◽  
Engineering Applications ◽  
Commercial Use ◽  
Microfabrication Techniques

Microfluidic devices currently play an important role in many biological, chemical, and engineering applications, and there are many ways to fabricate the necessary channel and feature dimensions. In this review, we provide an overview of microfabrication techniques that are relevant to both research and commercial use. A special emphasis on both the most practical and the recently developed methods for microfluidic device fabrication is applied, and it leads us to specifically address laminate, molding, 3D printing, and high resolution nanofabrication techniques. The methods are compared for their relative costs and benefits, with special attention paid to the commercialization prospects of the various technologies.

Chemically robust succinimide-group-assisted irreversible bonding of poly(dimethylsiloxane)–thermoplastic microfluidic devices at room temperature

The Analyst ◽  
2020 ◽  
Vol 145 (21) ◽  
pp. 6887-6894
Author(s):  
Rajamanickam Sivakumar ◽  
Nae Yoon Lee
Keyword(s):  
Chemical Modification ◽  
Room Temperature ◽  
Microfluidic Devices ◽  
Surface Chemical ◽  
Amino Silane ◽  
Silicon Based ◽  
Surface Chemical Modification

This study investigates surface chemical modification using anhydride silane and amino silane reagents at room temperature (RT) to realize bonding between silicon-based PDMS and non-silicon thermoplastics.

scholarly journals A rapid-prototyped moulding system towards optimised scalable fabrication of elastomeric microfluidic devices

2021 ◽  
Author(s):  
Christine Poon ◽  
Albert Fahrenbach
Keyword(s):  
3D Printing ◽  
Microfluidic Device ◽  
Lean Manufacturing ◽  
Soft Lithography ◽  
Low Cost ◽  
Microfluidic Devices ◽  
Petri Dish ◽  
Device Fabrication ◽  
Alternative Techniques ◽  
Optimisation Techniques

3D printing and makerspace technologies are increasingly explored as alternative techniques to soft lithography for making microfluidic devices, and for their potential to segue towards scalable commercial fabrication. Here we considered the optimal application of current benchtop 3D printing for microfluidic device fabrication through the lens of lean manufacturing and present a straightforward but robust rapid prototyped moulding system that enables easy estimation of more precise quantities of polydimethylsiloxane (PDMS) required per device to reduce waste and importantly, making devices with better defined depths and volumes for (i) modelling gas exchange and (ii) fabrication consistency as required for quality-controlled production. We demonstrate that this low-cost moulding step can enable a 40 – 300% reduction in the amount of PDMS required for making individual devices compared to the established method of curing approximately 30 grams of PDMS prepolymer overlaid on a 4” silicon wafer master in a standard plastic petri dish. Other process optimisation techniques were also investigated and are recommended as readily implementable changes to current laboratory and foundry-level microfluidic device fabrication protocols for making devices either out of PDMS or other elastomers. Simple calculators are provided as a step towards more streamlined, software controlled and automated design-to-fabrication workflows for both custom and scalable lean manufacturing of microfluidic devices.

scholarly journals Cat-CrNP as new material with catalytic properties for 2-chloro-2-propen-1-ol and ethylene oligomerizations

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Jacek Malinowski ◽  
Dagmara Jacewicz ◽  
Artur Sikorski ◽  
Mariusz Urbaniak ◽  
Przemysław Rybiński ◽  
...  
Keyword(s):  
Complex Compound ◽  
Atmospheric Pressure ◽  
Room Temperature ◽  
Organometallic Compounds ◽  
Ethylene Oligomerization ◽  
High Catalytic Activity ◽  
New Material ◽  
Activity Requirement ◽  
Olefin Oligomerization ◽  
Xrd Method

AbstractThe contemporary search for new catalysts for olefin oligomerization and polymerization is based on the study of coordinating compounds and/or organometallic compounds as post-metallocene catalysts. However known catalysts are suffered by many flaws, among others unsatisfactory activity, requirement of high pressure or instability at high temperatures. In this paper, we present a new catalyst i.e. the crystalline complex compound possesing high catalytic activity in the oligomerization of olefins, such as 2-chloro-2-propen-1-ol and ethylene under very mild conditions (room temperature, 0.12 bar for ethylene oligomerization, atmospheric pressure for 2-chloro-2-propen-1-ol oligomerization). New material—Cat-CrNP ([nitrilotriacetato-1,10-phenanthroline]chromium(III) tetrahydrate) has been obtained as crystalline form of the nitrilotriacetate complex compound of chromium(III) with 1,10-phenanthroline and characterized in terms of its crystal structure by the XRD method and by multi-analytical investigations towards its physicochemical propeties The yield of catalytic oligomerization over Cat-CrNP reached to 213.92 g · mmol−1 · h−1· bar−1 and 3232 g · mmol−1 · h−1 · bar−1 for the 2-chloro-2-propen-1-ol and ethylene, respectively. Furthemore, the synthesis of Cat-CrNP is cheap, easy to perform and solvents used during preparation are environmentally friendly.

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