Selective ratiometric red-emission detection of In3+ in aqueous solutions and in live cells using a fluorescent peptidyl probe and metal chelating agent

The Analyst ◽  
2020 ◽  
Vol 145 (11) ◽  
pp. 4031-4040
Author(s):  
Joohee Park ◽  
Hyeongseok Yu ◽  
See-Hyoung Park ◽  
Keun-Hyeung Lee
Keyword(s):  
Aqueous Solutions ◽  
Ground Water ◽  
Detection Method ◽  
Chelating Agent ◽  
Fluorescent Detection ◽  
Live Cells ◽  
Red Emission ◽  
Metal Chelating ◽  
Emission Detection

A ratiometric fluorescent detection method for In3+ in aqueous buffered solution, ground water, and live cells was developed.

Ratiometric red-emission fluorescence detection of Al3+in pure aqueous solution and live cells by a fluorescent peptidyl probe using aggregation-induced emission

The Analyst ◽  
2018 ◽  
Vol 143 (21) ◽  
pp. 5285-5294 ◽  
Author(s):  
Lok Nath Neupane ◽  
Pramod Kumar Mehta ◽  
Semin Oh ◽  
See-Hyoung Park ◽  
Keun-Hyeung Lee
Keyword(s):  
Aqueous Solution ◽  
Aqueous Solutions ◽  
Fluorescence Detection ◽  
Live Cells ◽  
Red Emission ◽  
Aggregation Induced Emission ◽  
Ratiometric Detection ◽  
Pure Aqueous Solution

A novel peptidyl probe using aggregation induced emission was proposed for the selective ratiometric detection of Al3+ions in pure aqueous solutions and live cells.

Selective red-emission detection for mercuric ions in aqueous solution and cells using a fluorescent probe based on an unnatural peptide receptor

2019 ◽  
Vol 17 (14) ◽  
pp. 3590-3598 ◽  
Author(s):  
Lok Nath Neupane ◽  
Pramod Kumar Mehta ◽  
Joon-Uk Kwon ◽  
See-Hyoung Park ◽  
Keun-Hyeung Lee
Keyword(s):  
Aqueous Solution ◽  
Fluorescent Probe ◽  
Live Cells ◽  
Red Emission ◽  
Peptide Receptor ◽  
Significant Challenge ◽  
Mercuric Ions ◽  
Emission Detection

The selective ratiometric red-emission detection of Hg2+ions in aqueous buffered solutions and live cells is still a significant challenge.

The colorimetric and ratiometric fluorescent detection of cyanide and sulfide in live cells, application for logic gate and bioimging

2017 ◽  
Vol 58 (1) ◽  
pp. 30-34 ◽  
Author(s):  
Hongda Li ◽  
Pengcheng Zhao ◽  
Ning Zou ◽  
Hui Wang ◽  
Kaixuan Sun
Keyword(s):  
Logic Gate ◽  
Fluorescent Detection ◽  
Live Cells

Highly selective colorimetric and fluorescent detection for Hg2+ in aqueous solutions using a dipeptide-based chemosensor

RSC Advances ◽  
2015 ◽  
Vol 5 (69) ◽  
pp. 56356-56361 ◽  
Author(s):  
Jooyoung Park ◽  
Byunggyu In ◽  
Keun-Hyeung Lee
Keyword(s):  
Aqueous Solutions ◽  
Fluorescent Detection

A dipeptide-based chemosensor selectively and sensitively detected HgII in aqueous solutions by colorimetric change and fluorescent change.

Antidotes — inappropriate timely availability

2000 ◽  
Vol 19 (9) ◽  
pp. 485-488 ◽  
Author(s):  
M A Higgins ◽  
R Evans
Keyword(s):  
Heavy Metal ◽  
Chelating Agent ◽  
The South ◽  
Chemical Safety ◽  
Metal Chelating ◽  
South West ◽  
Accident And Emergency ◽  
Cyanide Antidote ◽  
International Programme ◽  
Timely Fashion

The aim of this study was to determine the availability of antidotes to poisons in Wales and the South West of England. A stocklist of antidotes that are available to accident and emergency departments was requested and was compared with recommendations from the International Programme on Chemical Safety (IPCS). Chief pharmacists were invited to complete a short questionnaire regarding knowledge of existing guidelines. Thirty-four of 43 centres replied (response rate 77%). No department held all 36 antidotes (mean 13, range 7-33). All departments held antidotes that were frequently used. Ninety-one percent of departments held one cyanide antidote. Eighty-eight percent held one heavy metal chelating agent. The remaining antidotes were variably stocked. New agents such as 4-methylpyrazole, hydroxocobalamin and the heavy metal chelating agents DMSA and DMPS were infrequently held. Twenty of 34 chief pharmacists were unfamiliar with existing UK guidelines. A trend exists whereby larger departments stocked more antidotes. Some antidotes to poisons are not available in a timely fashion in Wales and the South West of England. There is a lack of awareness of existing guidelines. New recommendations relevant to clinical need and local practice should ideally be developed.

Modification of cisplatin toxicity with diethyldithiocarbamate.

1990 ◽  
Vol 8 (9) ◽  
pp. 1585-1590 ◽  
Author(s):  
J M Berry ◽  
C Jacobs ◽  
B Sikic ◽  
J Halsey ◽  
R F Borch
Keyword(s):  
Heavy Metal ◽  
Platelet Count ◽  
Chelating Agent ◽  
Cranial Irradiation ◽  
Limiting Factor ◽  
Preclinical Studies ◽  
Dose Escalation Study ◽  
Metal Chelating ◽  
Wbc Count ◽  
Local Burning

Diethyldithiocarbamate (DDTC), a heavy metal-chelating agent, has been shown to decrease cisplatin (CP) toxicity in preclinical studies. This phase I dose-escalation study was undertaken to investigate DDTC as a chemoprotector in patients with advanced cancer. Thirty-five courses of CP in doses ranging from 120 to 160 mg/m2 were given intravenous (IV) bolus to 19 patients. DDTC at 4 g/m2 was infused over 1 hour, starting 45 minutes after CP. There was minimal nephrotoxicity with a mean creatine clearance of 99 mL/min +/- 4 pretreatment and 86 mL/min +/- 4 on day 21. Two courses were associated with a WBC count less than 2,000/mm3 and one course with a platelet count of 15,000/mm3. Two patients had grade 2 neurotoxicity. Hearing loss occurred in 11 patients: five greater than or equal to 20 dB, five greater than or equal to 40 dB, and one greater than or equal to 60 dB. All patients who received cranial irradiation had ototoxicity compared with 43% of those without radiation (P less than .05). All patients experienced toxicity during the DDTC infusion, including hypertension, flushing, diaphoresis, agitation, and local burning. We conclude that DDTC can protect against CP nephrotoxicity at doses up to 160 mg/m2. Ototoxicity became the dose-limiting factor.

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