CXCVIII.—The decomposition of ethylene bromide by potassium iodide and sodium iodide solutions

1924 ◽  
Vol 125 (0) ◽  
pp. 1526-1527 ◽  
Author(s):  
T. S. Patterson ◽  
John Robertson
Keyword(s):  
Potassium Iodide ◽  
Sodium Iodide

scholarly journals A putative mechanism of the Sodium/Iodide Symporter regulation during repetitive administration of stable Iodide described by a Systems Biology approach

2019 ◽  
Vol 14 ◽  
pp. 05008
Author(s):  
David Cohen ◽  
Dalila Lebsir ◽  
Karine Tack ◽  
Marc Benderitter ◽  
Maâmar Souidi
Keyword(s):  
Single Dose ◽  
Systems Biology ◽  
Adverse Effects ◽  
Potassium Iodide ◽  
Sodium Iodide ◽  
Prolonged Exposure ◽  
Male Rats ◽  
Sodium Iodide Symporter ◽  
Efficient Protection ◽  
Putative Mechanism

A single dose of potassium iodide (KI) against a prolonged exposure to repeated radioactivity might not be effective enough to protect the thyroid. Our group have shown that a repetitive dose of KI for eight days offers efficient protection without adverse effects in male rats [1].

THE EFFECT OF POTASSIUM IODIDE, SODIUM IODIDE, AND IOD-ETHAMINE UPON THE CONCENTRATION OF ALCOHOL-SOLUBLE AND ALCOHOL-INSOLUBLE FRACTIONS OF BLOOD IODINE

1945 ◽  
Vol 23e (6) ◽  
pp. 206-211
Author(s):  
Eldon M. Boyd ◽  
M. C. Blanchaer
Keyword(s):  
Respiratory Tract ◽  
Potassium Iodide ◽  
Sodium Iodide ◽  
Soluble Fraction ◽  
Insoluble Fraction ◽  
Stomach Tube ◽  
Simple Diffusion

Potassium iodide, sodium iodide, and Iod-Ethamine were given by stomach tube to 54 rabbits and the concentration of alcohol-soluble and -insoluble blood iodine followed for a period up to 24 hr. Following all three iodides, there was a rise and fall in the values of both fractions of blood iodine, the values for the alcohol-soluble fraction rising to the higher levels but declining more rapidly than the values for the alcohol-insoluble fraction. Potassium iodide had the advantage over sodium iodide that after its use the peak levels of both fractions of blood iodine were maintained for a longer period of time. Iod-Ethamine had the advantage over potassium iodide that higher peak levels were reached with both fractions of blood iodine and, while not maintained for as long as after potassium iodide, these peak levels were held for several hours and for a longer period than following sodium iodide. The concentrations of blood iodine were of the same order or higher than those found in respiratory tract fluid following administration of the same dose of iodides, suggesting that the appearance of iodine-containing substances in respiratory tract fluid (R.T.F.) after iodide therapy is of the nature of a simple diffusion from blood.

scholarly journals Equine Sporotrichosis and Iatrogenic Hypothyroidism

2016 ◽  
Vol 44 (1) ◽  
pp. 6
Author(s):  
André Giarola Boscarato ◽  
Luiz Romulo Alberton ◽  
Henrique Augusto Elerbrock dos Santos Komochena ◽  
Emerson Botelho ◽  
Rita de Cássia Lima Ribeiro ◽  
...  
Keyword(s):  
Fungal Infection ◽  
Potassium Iodide ◽  
Liver Dysfunction ◽  
Side Effect ◽  
Thyroid Dysfunction ◽  
Sodium Iodide ◽  
Specific Treatment ◽  
The Body ◽  
Histopathological Analysis ◽  
Sodium And Potassium

 Background: Sporotrichosis is a subacute or chronic granulomatous fungal infection that affects the dermis and subcutane­ous tissue. Its etiology is related to a complex of Sporothrix spp. species of worldwide distribution. Usually, sporotrichosis results from traumatic inoculation of Sporothrix spp. into the dermis, affecting humans and other mammals, but a greater number of cases have been reported in felines, a fact increasingly important in the zoonotic transmission of diseased animals to man. In horses, there may be multiple ulcerated wounds covered with scabs and slightly elevated plaques or nodules that occur along lymphatic chains in limbs and can be unique and located. Iodides are considered drugs of choice for the treatment of sporotrichosis in horses. The main side effect of prolonged use of these substances is iodism and thyroid dysfunction. The aim of this study was to report a clinical case of sporotrichosis in an equine treated in the state of Paraná, southern Brazil, which showed secondary iatrogenic hypothyroidism with prolonged use of sodium and potassium iodide.Case: A female, 3-year-old, Quarter Horse, with 400 kg of liveweight presented at clinical examination of the cutaneous tissue elevated lesions of nodular aspect, with 2 to 4 cm in diameter, absence of itching and some nodules presenting alo­pecia areas in the chest and abdominal region, and in the anterior, posterior and internal regions of the hindlimbs, featuring diffuse distribution of lesions. Biopsy was performed for histological examination of affected tissue and microbiological culture in the attempt to isolate the etiologic agent. Treatment consisted of the use of intravenous potassium iodide (KI) at a dose of 2 mg / kg for 2 weeks, followed by oral sodium iodide (NaI) at a dose of 5 mg / kg, 10 days later and 20 mg / kg for a period of 65 days, totaling 100 days of treatment, during which hepatic, renal and thyroid functions were evaluated.Discussion: In the case described, empiric treatment with dexamethasone carried by the owner might have triggered the diffuse presentation of the disease restricted to the skin, as glucocorticoids interfere with immunity. The histopathological analysis of skin fragments obtained by biopsy and prepared with H.E. staining found mononucleate inflammatory infil­trate with the presence of lymphocytes and macrophages in deep dermis and necrotic foci. No microbiological isolation of S. schenckii was possible. They were described as a common side effect of the prolonged use of iodinated compounds, iodism and thyroid dysfunction. There were no changes in renal function; however, there was an increase in serum levels of ALT, GGT and FA, featuring liver dysfunction. Thyroid gland dysfunction was observed due to the low levels of thyroid hormones found in the bloodstream, featuring hypothyroidism. The animal of the present case report did not show clinical signs associated with hypothyroidism, which required no specific treatment, since normalization occurs with the gradual decrease of the body iodine levels after removal of the source. It was conclude that, despite the diffuse characteristic of the disease in the animal of this report, it was possible to obtain the clinical cure of sporotrichosis. Therapy with sodium and potassium iodide proved to be effective, but caution is recommended in the use of these drugs, as secondary iatrogenic hypothyroidism and liver dysfunction were observed due to the prolonged period of the required treatment.Keywords: hypothyroidism, fungal infection, sodium iodide, Sporothrix spp.

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