A novel in vivo nitric oxide sensor

1996 ◽  
pp. 23 ◽  
Author(s):  
Esther Leung ◽  
Peter J Cragg ◽  
Danny O'Hare ◽  
Michael O'Shea
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Sensor

A Simple Silicon Based Nitric Oxide Sensor

1999 ◽  
Author(s):  
Marcelo Bariatto ◽  
Rogerio Furlan ◽  
Koiti Arakai ◽  
Jorge J. Santiago-Aviles
Keyword(s):  
Nitric Oxide ◽  
Amperometric Detection ◽  
Cellular Level ◽  
High Yield ◽  
Sensor Calibration ◽  
Nitric Oxide Sensor ◽  
Sensor Configuration

Abstract Nitric oxide (NO) is known to mediate many beneficial physiology processes, motivating its detection in vivo as well as in vitro. Electrochemical detection provides the required cellular level determination of NO among several other techniques. In this work, electrochemical micro-sensors for both types of detection, in vivo and in vitro, were developed, exploring the silicon planar technology, which presents high yield and reliability and also permits batch fabrication. The developed in vitro sensor features eight detection sites (10 μm × 10 μm microelectrodes), for determination of nitric oxide spatial distribution or multi-species analysis. Different electrochemical methods were applied to provide sensor calibration and chemical reproducibility. For in vivo analysis, the designed structures have a needle shape (40 μm thick) and they were silicon micro-machined by using plasma etching or etch stop techniques. Different configurations were designed and implemented, containing a number of detection microelectrodes that vary from 2 to 10. The amperometric detection of both nitric oxide and nitride (NO2−) — a molecule that causes an interference — were investigated by using the in vitro micro-sensor configuration. The need of a cationic exchanger (Nafion) was demonstrated in order to provide selectivity to NO for low concentrations. Also, the developed sensor has a sensitivity of 500 A/M.cm2 and a detection limit of 10 μM.

A rhodamine-based turn-on nitric oxide sensor in aqueous medium with endogenous cell imaging: an unusual formation of nitrosohydroxylamine

2018 ◽  
Vol 16 (21) ◽  
pp. 3910-3920 ◽  
Author(s):  
Rabiul Alam ◽  
Abu Saleh Musha Islam ◽  
Mihir Sasmal ◽  
Atul Katarkar ◽  
Mahammad Ali
Keyword(s):  
Nitric Oxide ◽  
Aqueous Medium ◽  
Cell Imaging ◽  
Fluorescence Response ◽  
Turn On ◽  
Nitric Oxide Sensor ◽  
Unusual Formation

The sensor L3 selectively recognizes NO in purely aqueous medium with an unusual formation of nitrosohydroxylamine with a turn-on fluorescence response which might be suitable for in vivo application.

S4-01 In vivo evaluation of signaling molecule: development of catheter-type nitric oxide sensor

2004 ◽  
Vol 97 ◽  
pp. S10
Author(s):  
Masami Goto ◽  
Yoji Neishi ◽  
Seiichi Mochizuki ◽  
Takehiro Miyasaka ◽  
Renan Sukmawan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
In Vivo Evaluation ◽  
Signaling Molecule ◽  
Nitric Oxide Sensor

In vivo nitric oxide sensor using non-conducting polymer-modified carbon fiber

1998 ◽  
Vol 13 (11) ◽  
pp. 1187-1195 ◽  
Author(s):  
Je-Kyun Park ◽  
Peter H Tran ◽  
Johnny K.T Chao ◽  
Rutwik Ghodadra ◽  
Rajagopalan Rangarajan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Carbon Fiber ◽  
Conducting Polymer ◽  
Nitric Oxide Sensor

Evaluation of basic performance and applicability of a newly developed in vivo nitric oxide sensor

2002 ◽  
Vol 23 (3) ◽  
pp. 597-597 ◽  
Author(s):  
Seiichi Mochizuki ◽  
Naoyuki Himi ◽  
Takehiro Miyasaka ◽  
Hiroshi Nakamoto ◽  
Mami Takemoto ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Sensor ◽  
Basic Performance

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1314-1319 ◽  
Author(s):  
Robinson Joannides ◽  
Walter E. Haefeli ◽  
Lilly Linder ◽  
Vincent Richard ◽  
El Hassan Bakkali ◽  
...  
Keyword(s):  
Nitric Oxide
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