A rhodamine-based turn-on nitric oxide sensor in aqueous medium with endogenous cell imaging: an unusual formation of nitrosohydroxylamine

2018 ◽  
Vol 16 (21) ◽  
pp. 3910-3920 ◽  
Author(s):  
Rabiul Alam ◽  
Abu Saleh Musha Islam ◽  
Mihir Sasmal ◽  
Atul Katarkar ◽  
Mahammad Ali
Keyword(s):  
Nitric Oxide ◽  
Aqueous Medium ◽  
Cell Imaging ◽  
Fluorescence Response ◽  
Turn On ◽  
Nitric Oxide Sensor ◽  
Unusual Formation

The sensor L3 selectively recognizes NO in purely aqueous medium with an unusual formation of nitrosohydroxylamine with a turn-on fluorescence response which might be suitable for in vivo application.

A Simple Silicon Based Nitric Oxide Sensor

1999 ◽  
Author(s):  
Marcelo Bariatto ◽  
Rogerio Furlan ◽  
Koiti Arakai ◽  
Jorge J. Santiago-Aviles
Keyword(s):  
Nitric Oxide ◽  
Amperometric Detection ◽  
Cellular Level ◽  
High Yield ◽  
Sensor Calibration ◽  
Nitric Oxide Sensor ◽  
Sensor Configuration

Abstract Nitric oxide (NO) is known to mediate many beneficial physiology processes, motivating its detection in vivo as well as in vitro. Electrochemical detection provides the required cellular level determination of NO among several other techniques. In this work, electrochemical micro-sensors for both types of detection, in vivo and in vitro, were developed, exploring the silicon planar technology, which presents high yield and reliability and also permits batch fabrication. The developed in vitro sensor features eight detection sites (10 μm × 10 μm microelectrodes), for determination of nitric oxide spatial distribution or multi-species analysis. Different electrochemical methods were applied to provide sensor calibration and chemical reproducibility. For in vivo analysis, the designed structures have a needle shape (40 μm thick) and they were silicon micro-machined by using plasma etching or etch stop techniques. Different configurations were designed and implemented, containing a number of detection microelectrodes that vary from 2 to 10. The amperometric detection of both nitric oxide and nitride (NO2−) — a molecule that causes an interference — were investigated by using the in vitro micro-sensor configuration. The need of a cationic exchanger (Nafion) was demonstrated in order to provide selectivity to NO for low concentrations. Also, the developed sensor has a sensitivity of 500 A/M.cm2 and a detection limit of 10 μM.

A new visible-light-excitable ICT-CHEF-mediated fluorescence ‘turn-on’ probe for the selective detection of Cd2+ in a mixed aqueous system with live-cell imaging

2015 ◽  
Vol 44 (12) ◽  
pp. 5763-5770 ◽  
Author(s):  
Shyamaprosad Goswami ◽  
Krishnendu Aich ◽  
Sangita Das ◽  
Chitrangada Das Mukhopadhyay ◽  
Deblina Sarkar ◽  
...  
Keyword(s):  
Visible Light ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Aqueous System ◽  
Live Cell ◽  
Selective Detection ◽  
Turn On ◽  
Fluorescence Turn On

A new quinoline based sensor was developed and applied for the selective detection of Cd2+ both in vitro and in vivo.

A selective turn-on fluorescent probe for Al3+ based-on a diacylhydrazone deritive in aqueous medium and its cell imaging

2020 ◽  
Vol 259 ◽  
pp. 116234 ◽  
Author(s):  
Zheng Li ◽  
Fucai Dai ◽  
Jing Wang ◽  
Shujun Wang ◽  
Liwei Xiao ◽  
...  
Keyword(s):  
Aqueous Medium ◽  
Fluorescent Probe ◽  
Cell Imaging ◽  
Turn On

Exploring the potential of a urea derivative: an AIE-luminogen and its interaction with human serum albumin in aqueous medium

The Analyst ◽  
2019 ◽  
Vol 144 (8) ◽  
pp. 2696-2703 ◽  
Author(s):  
Senjuti Halder ◽  
Soham Samanta ◽  
Gopal Das
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Aqueous Medium ◽  
Urea Derivative ◽  
Urea Molecule ◽  
Fluorescence Response ◽  
Turn On

A simple AIE active urea molecule (L1) can selectively interact with HSAviaturn-on fluorescence response in aqueous medium.

A novel in vivo nitric oxide sensor

1996 ◽  
pp. 23 ◽  
Author(s):  
Esther Leung ◽  
Peter J Cragg ◽  
Danny O'Hare ◽  
Michael O'Shea
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Sensor

scholarly journals Facilitation of Molecular Motion in Nanoparticles and Development of Turn-on Photoacoustic Bioprobe for in Vivo Detection of Nitric Oxide in Encephalitis

2020 ◽  
Author(s):  
Ji Qi ◽  
Leyan Feng ◽  
Xiaoyan Zhang ◽  
Haoke Zhang ◽  
Liwen Huang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Molecular Probe ◽  
Energy Transformation ◽  
Disease Evolution ◽  
Turn On ◽  
In Vivo Detection ◽  
Specificity And Sensitivity ◽  
Intramolecular Motion ◽  
Transformation Processes

Nitric oxide (NO) is an important signaling molecule overexpressed in many diseases, thus the development of NO-activatable probes is of vital significance for monitoring related diseases. However, sensitive photoacoustic (PA) probes for detecting NO-associated complicated diseases (e.g., encephalitis), has yet to be developed. Herein, we report a NO-activated PA probe for in vivo detection of encephalitis by tuning the molecular geometry and energy transformation processes. A strong donor-acceptor structure with good conjugation can be obtained after NO treatment, along with the active intramolecular motion, significantly boosting “turn-on” near-infrared PA property. The molecular probe exhibits high specificity and sensitivity towards NO over interfering reactive species. Noninvasive in vivo imaging indicates that PA signal lights up in lipopolysaccharide-induced encephalitis with a high signal-to-background ratio of 15.7. Further studies reveal that the probe is also capable of differentiating encephalitis in different severities, being beneficial for understanding the disease evolution processes and drug screening. This work will inspire more insights into the development of high-performing NO-activated PA probes for advanced diagnosis by making full use of intramolecular motion and energy transformation processes.

A fluorescein-based chemosensor for “turn-on” detection of Hg2+ and the resultant complex as a fluorescent sensor for S2− in semi-aqueous medium with cell-imaging application: experimental and computational studies

2019 ◽  
Vol 43 (14) ◽  
pp. 5297-5307 ◽  
Author(s):  
Hasan Mohammad ◽  
Abu Saleh Musha Islam ◽  
Chandraday Prodhan ◽  
Mahammad Ali
Keyword(s):  
Aqueous Medium ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Fluorescent Sensor ◽  
Live Cell ◽  
Computational Studies ◽  
Turn On ◽  
Imaging Application

A fluorescein hydrazone based probe selectively recognizes Hg2+ ion with live cell imaging application.

A rhodamine based turn-on chemosensor for Fe3+ in aqueous medium and interactions of its Fe3+ complex with HSA

2017 ◽  
Vol 41 (20) ◽  
pp. 11661-11671 ◽  
Author(s):  
Rahul Bhowmick ◽  
Abu Saleh Musha Islam ◽  
Arindam Giri ◽  
Atul Katarkar ◽  
Mahammad Ali
Keyword(s):  
Amino Acids ◽  
Aqueous Medium ◽  
Live Cell Imaging ◽  
Cell Imaging ◽  
Metal Cations ◽  
Live Cell ◽  
Turn On

A novel hexa-coordinating rhodamine-based chemosensor, HL6, selectively and rapidly recognizes Fe3+ in the presence of a number of metal cations, numerous anions and amino acids in purely aqueous medium with live cell imaging applications.

S4-01 In vivo evaluation of signaling molecule: development of catheter-type nitric oxide sensor

2004 ◽  
Vol 97 ◽  
pp. S10
Author(s):  
Masami Goto ◽  
Yoji Neishi ◽  
Seiichi Mochizuki ◽  
Takehiro Miyasaka ◽  
Renan Sukmawan ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
In Vivo Evaluation ◽  
Signaling Molecule ◽  
Nitric Oxide Sensor
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