Controllable fabrication of stimuli-responsive fluorescent silica nanoparticles using a tetraphenylethene-functionalized carboxylate gemini surfactant

2019 ◽  
Vol 7 (40) ◽  
pp. 12588-12600 ◽  
Author(s):  
Saisai Yan ◽  
Zhinong Gao ◽  
Jia Han ◽  
Zhengqin Zhang ◽  
Fei Niu ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Gemini Surfactant ◽  
Stimuli Responsive ◽  
Fluorescent Silica Nanoparticles ◽  
Synthetic Strategy ◽  
Controllable Fabrication

A fluorophore-free green synthetic strategy was presented for the preparation of stimuli-responsive FSNs, which could be further tuned using N16-TPE-N16.

scholarly journals Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 71
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Cancer Therapy ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Therapeutic Agents ◽  
Metal Species ◽  
Stimuli Responsive ◽  
Combination Drug ◽  
Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

scholarly journals Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

2012 ◽  
Vol 2012 ◽  
pp. 1-20 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Surrounding Medium ◽  
Stimuli Responsive ◽  
Guest Molecules ◽  
Different Types ◽  
Potential Applications ◽  
Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

scholarly journals A New Theranostic System Based on Endoglin Aptamer Conjugated Fluorescent Silica Nanoparticles

Theranostics ◽  
2017 ◽  
Vol 7 (19) ◽  
pp. 4862-4876 ◽  
Author(s):  
Juntao Tan ◽  
Nuo Yang ◽  
Liping Zhong ◽  
Jie Tan ◽  
Zixi Hu ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Fluorescent Silica Nanoparticles

Bright and stable Cy3-encapsulated fluorescent silica nanoparticles with a large Stokes shift

2012 ◽  
Vol 93 (1-3) ◽  
pp. 1532-1537 ◽  
Author(s):  
Gengwen Chen ◽  
Fengling Song ◽  
Xu Wang ◽  
Shiguo Sun ◽  
Jiangli Fan ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Stokes Shift ◽  
Large Stokes Shift ◽  
Fluorescent Silica Nanoparticles

scholarly journals Correction: Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods

2020 ◽  
Vol 8 (43) ◽  
pp. 9997-9997
Author(s):  
Long Jiao ◽  
Fengling Song ◽  
Biyou Zhang ◽  
Houfu Ning ◽  
Jingnan Cui ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Fine Tuning ◽  
Fluorescent Silica Nanoparticles ◽  
Encapsulation Methods

Correction for ‘Improving the brightness and photostability of NIR fluorescent silica nanoparticles through rational fine-tuning of the covalent encapsulation methods’ by Long Jiao et al., J. Mater. Chem. B, 2017, 5, 5278–5283, DOI: 10.1039/C7TB00856B.

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