A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract

2020 ◽  
Vol 8 (4) ◽  
pp. 666-676 ◽  
Author(s):  
Yan Zu ◽  
Liang Yan ◽  
Tao Wang ◽  
Dongqing Ma ◽  
Xinghua Dong ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Contrast Agent ◽  
Infected Mouse ◽  
Gi Tract ◽  
Antibacterial Ability ◽  
Dual Functional ◽  
Enhanced Ct ◽  
Ct Contrast Agent ◽  
Ct Contrast

A dual-functional Bi2S3@mSiO2@Ag nanocomposite can be used as an efficient CT contrast agent to visualize the whole GI tract. And this nanocomposite also has effective antibacterial ability to intestine-infected mouse.

Abstract 1905: Quantification Of Macrophages In Atherosclerotic Plaques Of Rabbits Using The Novel Specific Ct Contrast Agent N1177: A Comparison With 18f-fdg Uptake On Pet-ct And Histology

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Fabien Hyafil ◽  
James H Rudd ◽  
Jean-Christophe Cornily ◽  
Ash Rafique ◽  
Laurent J Feldman ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Metabolic Activity ◽  
Aortic Wall ◽  
Atherosclerotic Plaques ◽  
Fdg Uptake ◽  
Pet Ct ◽  
Enhanced Ct ◽  
Ct Contrast Agent ◽  
18F Fdg ◽  
Ct Contrast

Introduction. N1177 is a novel computed tomography (CT) contrast agent taken up by macrophages. Purpose. We tested if the enhancement detected on CT in aortic wall of rabbits 2 hours after injection of N1177 correlates with metabolic activity measured with 18F-FDG uptake on positron emission tomography (PET)-CT and macrophage area on histology. Methods. Atherosclerotic plaques were induced in the aorta of 7 New-Zealand White rabbits by a repeated balloon injury (4 weeks apart) and 4 months of hyperlipemic diet. Three non-injured rabbits fed a chow diet were used as controls. A CT of the aorta (n=10) was acquired in each rabbit before and 2 hours after intravenous injection of N1177 (250 mg iodine/kg). One week later, the same rabbits were imaged on a PET-CT 3 hours after injection of 1 mCi/kg of 18F-FDG. Enhancement of the aortic wall after injection of N1177 was compared to the SUV on PET-CT, and to macrophage area on immunohistochemistry (anti-RAM-11 antibody) of corresponding sections. Results. A significant higher enhancement was measured on N1177-enhanced CT in the aortic wall of atherosclerotic compared to control rabbits (mean increase of 10.0 ± 5.2 Hounsfield Units vs. 2.0 ± 2.1 HU, respectively; p<0.05). We found a strong correlation between the enhancement of the aortic wall measured on N1177-enhanced CT (Fig .: before (A) and 2 hours after (B) injection of N1177) and FDG uptake on PET-CT (Fig. C ; r=0.61, p<0.001), macrophage area on immunohistology (Fig. D ; r=0.63, p<0.001). Conclusion. Enhancement detected in the aortic wall of rabbits with N1177-enhanced CT correlated with intense metabolic activity measured with 18-F-FDG on PET-CT and with macrophage area on histology.

SU-E-I-13: A Model for CT Contrast Agent Evaluation

2011 ◽  
Vol 38 (6Part4) ◽  
pp. 3398-3398
Author(s):  
M Bonvento ◽  
S Jambawalikar ◽  
T Button
Keyword(s):  
Contrast Agent ◽  
Ct Contrast Agent ◽  
Ct Contrast

D-Glucuronic Acid-Coated Ultrasmall Bi2O3 Nanoparticles for CT Imaging

2020 ◽  
Vol 20 (8) ◽  
pp. 4638-4642
Author(s):  
Adibehalsadat Ghazanfari ◽  
Shanti Marasini ◽  
Huan Yue ◽  
Son Long Ho ◽  
Xu Miao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Glucuronic Acid ◽  
Number Density ◽  
Atomic Concentration ◽  
Attenuation Coefficients ◽  
X Ray ◽  
Ct Contrast Agent ◽  
One Step ◽  
First Time ◽  
Ct Contrast

Ultrasmall Bi2O3 nanoparticles (davg = 1.5 nm) coated with biocompatible and hydrophilic D-glucuronic acid were prepared for the first time through a simple one-step polyol process and their potential as CT contrast agents were investigated by measuring their X-ray attenuation properties. Their observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent at the same atomic concentration, as consistent with the magnitudes of atomic X-ray attenuation coefficients (i.e., Bi > I), and much stronger at the same number density. The results indicate that the nanoparticle sample is a potential CT contrast agent.

cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

2020 ◽  
Vol 11 (4) ◽  
pp. 889-899 ◽  
Author(s):  
Chunhui Gao ◽  
Yinghua Zhang ◽  
Yan Zhang ◽  
Shaoyong Li ◽  
Xinlin Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contrast Agent ◽  
Disulfide Bond ◽  
Polymer Nanoparticles ◽  
Targeted Imaging ◽  
Crosslinked Polymer ◽  
Ct Contrast Agent ◽  
Surface Modified ◽  
Ct Contrast

The disulfide bond-crosslinked polymer nanoparticles based on iopamidol were prepared and then surface-modified with cRGD peptide through the linkages of PEG to acquire a CT contrast agent for breast cancer-targeted imaging.

An assessment of Gd-DTPA as a CT contrast agent in the renal tract

1993 ◽  
Vol 47 (4) ◽  
pp. 278-279 ◽  
Author(s):  
R.J. Gibson ◽  
C.I. Meanock ◽  
E.P.H. Torrie ◽  
T.M. Walker
Keyword(s):  
Contrast Agent ◽  
Ct Contrast Agent ◽  
Ct Contrast

Gadolinium as a CT Contrast Agent: Assessment in a Porcine Model

Radiology ◽  
1999 ◽  
Vol 210 (3) ◽  
pp. 829-834 ◽  
Author(s):  
David S. Gierada ◽  
Kyongtae T. Bae
Keyword(s):  
Contrast Agent ◽  
Porcine Model ◽  
Ct Contrast Agent ◽  
Ct Contrast

Nanoscaled Iodized Oil Emulsion as a CT Contrast Agent for the Detection of Experimental Liver Tumors in a Rat Model

2010 ◽  
Vol 17 (8) ◽  
pp. 985-991 ◽  
Author(s):  
Soo-Jeong Lim ◽  
Joon Seok Lim ◽  
Junjeong Choi ◽  
Jin-Young Choi ◽  
Woo Jin Hyung ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Rat Model ◽  
Liver Tumors ◽  
Iodized Oil ◽  
Oil Emulsion ◽  
Ct Contrast Agent ◽  
Experimental Liver ◽  
Ct Contrast
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