Rhenium Sulfide Nanoparticles as a Biosafe Spectral CT Contrast Agent for Gastrointestinal Tract Imaging and Tumor Theranostics in Vivo

2019 ◽  
Vol 11 (37) ◽  
pp. 33650-33658 ◽  
Author(s):  
Xiaoyi Wang ◽  
Jiaojiao Wang ◽  
Jinbin Pan ◽  
Fangshi Zhao ◽  
Di Kan ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Contrast Agent ◽  
Spectral Ct ◽  
Ct Contrast Agent ◽  
Rhenium Sulfide ◽  
Ct Contrast ◽  
Tumor Theranostics

scholarly journals A novel CT contrast agent for intestinal-targeted imaging through rectal administration

e-Polymers ◽  
2021 ◽  
Vol 21 (1) ◽  
pp. 754-762
Author(s):  
Jingyao Zhu ◽  
Hao Weng ◽  
Shichen Xie ◽  
Jiejun Cheng ◽  
Jun Zhu
Keyword(s):  
Contrast Agent ◽  
Rectal Administration ◽  
Iodinated Contrast ◽  
Rectal Route ◽  
Ct Contrast Agent ◽  
Potential Applications ◽  
Iodinated Contrast Agent ◽  
Targeting Ability ◽  
Ct Contrast

Abstract In this study, a novel CT contrast agent used by rectal administration is developed for targeting intestinal imaging. Iopamidol, an iodinated contrast agent, is loaded in chitosan (CS) nanospheres modified by Anti-5-HT3R (AH) antibody. The obtained AH-CS-I nanospheres (AH-CS-I Ns) would combine to 5-HT3 receptors highly expressed on the gastrointestinal mucosal, enhancing the intestinal-targeting ability of the contrast agent. The AH-CS-I Ns were administered by the rectal route for intestinal CT imaging, and FITC-labeled AH-CS-I Ns were prepared for investigating the in vivo distribution of the contrast agent. As a result, obvious contrast enhancement could still be observed at 6 h post administration because of the poorly absorption of enteral AH-CS-I Ns. Unlike the intravascularly administered agents, AH-CS-I Ns would not accumulate in the kidney and induce adverse reactions. Therefore, this technology has potential applications in the examination of intestinal diseases and could reduce the side effect of commercial iopamidol.

A Functional CT Contrast Agent for In Vivo Imaging of Tumor Hypoxia

Small ◽  
2016 ◽  
Vol 12 (29) ◽  
pp. 3995-4006 ◽  
Author(s):  
Hongyuan Shi ◽  
Zhiming Wang ◽  
Chusen Huang ◽  
Xiaoli Gu ◽  
Ti Jia ◽  
...  
Keyword(s):  
Contrast Agent ◽  
In Vivo Imaging ◽  
Tumor Hypoxia ◽  
Ct Contrast Agent ◽  
Functional Ct ◽  
Ct Contrast

Bi-DTPA as a high-performance CT contrast agent for in vivo imaging

Biomaterials ◽  
2019 ◽  
Vol 203 ◽  
pp. 1-11 ◽  
Author(s):  
Weihua Liao ◽  
Peng Lei ◽  
Jinbin Pan ◽  
Cai Zhang ◽  
Xianting Sun ◽  
...  
Keyword(s):  
Contrast Agent ◽  
In Vivo Imaging ◽  
High Performance ◽  
Ct Contrast Agent ◽  
Ct Contrast

scholarly journals Corrigendum to “Bi-DTPA as a high-performance CT contrast agent for in vivo imaging” [Biomaterials 203(2019) 1–11]

Biomaterials ◽  
2021 ◽  
Vol 277 ◽  
pp. 121122
Author(s):  
Weihua Liao ◽  
Peng Lei ◽  
Jinbin Pan ◽  
Cai Zhang ◽  
Xianting Sun ◽  
...  
Keyword(s):  
Contrast Agent ◽  
In Vivo Imaging ◽  
High Performance ◽  
Ct Contrast Agent ◽  
Ct Contrast

Contrast enhancement of iohexol-cisplatin-gelatin complex under computed tomography imaging

2014 ◽  
Vol 34 (3) ◽  
pp. 267-271
Author(s):  
Wei-Hung Liu ◽  
Yang-Kao Wang ◽  
Chi-Chang Wu ◽  
Win-Pin Deng ◽  
Kuang-Hsun Lin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Contrast Agent ◽  
Diagnostic Techniques ◽  
The Body ◽  
X Ray ◽  
Non Invasive ◽  
Ct Contrast Agent ◽  
X Ray Computed ◽  
Ct Contrast

Abstract X-ray computed tomography (CT) is one of the most powerful non-invasive diagnostic techniques nowadays. The iodinated molecules used as CT contrast agents in the clinic have short circulation times in the body, which significantly restrict its applications. Furthermore, some patients are hypersensitive to iodine. So, researchers have made tremendous efforts to improve the property of iodine. Besides, cis-diammineplatinum (II) dichloride (cisplatin), a major chemo agent for cancer treatment, possess higher X-ray attenuation coefficient being a CT contrast agent. The incorporation of cisplatin with an iodinated agent could facilitate the quality of CT images and damage cancer cells simultaneously. To reduce toxicity of a contrast agent, polymer matrix, gelatin, was incorporated for avoiding contact with nontarget cells. In this study, we combined the iodine contrast agent, 1,3-N-bis (2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodobenzene-1,3-dicarboxamide (iohexol), with cisplatin, and then examined them in a micro CT with different X-ray tube voltages (50 kV, 80 kV, 100 kV) to find optimal scanning conditions for imaging. As expected, iohexol combined with cisplatin enhanced X-ray attenuation and image contrast. The optimal CT image could be acquired at iohexol and cisplatin concentrations of 50 mg/ml and 3 mg/ml, respectively, under 80 kV irradiation. Finally, the iohexol-cisplatin-gelatin solution was then fabricated into nanoparticles of sizes about 240 nm, which may suitable for in vivo delivery.

A Bi2S3@mSiO2@Ag nanocomposite for enhanced CT visualization and antibacterial response in the gastrointestinal tract

2020 ◽  
Vol 8 (4) ◽  
pp. 666-676 ◽  
Author(s):  
Yan Zu ◽  
Liang Yan ◽  
Tao Wang ◽  
Dongqing Ma ◽  
Xinghua Dong ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Contrast Agent ◽  
Infected Mouse ◽  
Gi Tract ◽  
Antibacterial Ability ◽  
Dual Functional ◽  
Enhanced Ct ◽  
Ct Contrast Agent ◽  
Ct Contrast

A dual-functional Bi2S3@mSiO2@Ag nanocomposite can be used as an efficient CT contrast agent to visualize the whole GI tract. And this nanocomposite also has effective antibacterial ability to intestine-infected mouse.

Gram-scale synthesis of a neodymium chelate as a spectral CT and second near-infrared window imaging agent for visualizing the gastrointestinal tract in vivo

2021 ◽  
Author(s):  
Pengrui Zhuang ◽  
Ke Xiang ◽  
Xiangxi Meng ◽  
Guohe Wang ◽  
Ziyuan Li ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Fluorescence Imaging ◽  
Large Scale ◽  
Near Infrared ◽  
Imaging Agent ◽  
Spectral Ct ◽  
Green Method ◽  
Infrared Window

A facile and green method was developed to fabricate Nd-DTPA on a large scale without byproducts for CT/spectral CT and NIR II fluorescence imaging of the gastrointestinal tract in vivo.

SU-E-I-13: A Model for CT Contrast Agent Evaluation

2011 ◽  
Vol 38 (6Part4) ◽  
pp. 3398-3398
Author(s):  
M Bonvento ◽  
S Jambawalikar ◽  
T Button
Keyword(s):  
Contrast Agent ◽  
Ct Contrast Agent ◽  
Ct Contrast

D-Glucuronic Acid-Coated Ultrasmall Bi2O3 Nanoparticles for CT Imaging

2020 ◽  
Vol 20 (8) ◽  
pp. 4638-4642
Author(s):  
Adibehalsadat Ghazanfari ◽  
Shanti Marasini ◽  
Huan Yue ◽  
Son Long Ho ◽  
Xu Miao ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Glucuronic Acid ◽  
Number Density ◽  
Atomic Concentration ◽  
Attenuation Coefficients ◽  
X Ray ◽  
Ct Contrast Agent ◽  
One Step ◽  
First Time ◽  
Ct Contrast

Ultrasmall Bi2O3 nanoparticles (davg = 1.5 nm) coated with biocompatible and hydrophilic D-glucuronic acid were prepared for the first time through a simple one-step polyol process and their potential as CT contrast agents were investigated by measuring their X-ray attenuation properties. Their observed X-ray attenuation power was stronger than that of a commercial iodine CT contrast agent at the same atomic concentration, as consistent with the magnitudes of atomic X-ray attenuation coefficients (i.e., Bi > I), and much stronger at the same number density. The results indicate that the nanoparticle sample is a potential CT contrast agent.

cRGD-modified and disulfide bond-crosslinked polymer nanoparticles based on iopamidol as a tumor-targeted CT contrast agent

2020 ◽  
Vol 11 (4) ◽  
pp. 889-899 ◽  
Author(s):  
Chunhui Gao ◽  
Yinghua Zhang ◽  
Yan Zhang ◽  
Shaoyong Li ◽  
Xinlin Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Contrast Agent ◽  
Disulfide Bond ◽  
Polymer Nanoparticles ◽  
Targeted Imaging ◽  
Crosslinked Polymer ◽  
Ct Contrast Agent ◽  
Surface Modified ◽  
Ct Contrast

The disulfide bond-crosslinked polymer nanoparticles based on iopamidol were prepared and then surface-modified with cRGD peptide through the linkages of PEG to acquire a CT contrast agent for breast cancer-targeted imaging.

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