Facile synthesis of polypyrrole–rhodamine B nanoparticles for self-monitored photothermal therapy of cancer cells

2020 ◽  
Vol 8 (5) ◽  
pp. 1033-1039 ◽  
Author(s):  
Xiao-Hui Wang ◽  
Xue-Qiao Chen ◽  
Hong-Shang Peng ◽  
Xiao-Fei Wei ◽  
Xiao-Juan Wang ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Real Time ◽  
Rhodamine B ◽  
Photothermal Therapy ◽  
Temperature Monitoring ◽  
Facile Synthesis ◽  
Functional Nanoparticles ◽  
Dual Functional ◽  
Photothermal Ablation

Biocompatible dual-functional nanoparticles combining polypyrrole with rhodamine B are constructed for photothermal ablation of cancer cells and real-time temperature monitoring during PTT.

A Photothermal Therapy Strategy for Monitoring Real-Time Temperature in Kidney Cancers by Injecting Gold Nanorods with Phosphors

2021 ◽  
Vol 17 (3) ◽  
pp. 501-508
Author(s):  
Wenzeng Shen ◽  
Xuefeng Zhang ◽  
Dongyang Liu ◽  
Christina Xing ◽  
Isabelle Tucker ◽  
...  
Keyword(s):  
Real Time ◽  
Gold Nanorods ◽  
Photothermal Therapy ◽  
Normal Tissue ◽  
Temperature Monitoring ◽  
Internal Temperature ◽  
Absorbed Energy ◽  
Ablation Therapy ◽  
Photothermal Ablation ◽  
Therapy Strategy

Photothermal ablation therapy (PTA) has been widely reported; however, it is not possible to predict the internal temperature of the tumor in real time that causes ineffective treatment and normal tissue burns. Here, we have designed a photothermal therapy strategy under real-time temperature monitoring by injecting gold nanorods (AuNRs) and NaYF4: Yb3+ /Er3+ into the tumor site where AuNRs are used for PTA of cancer cells by converting the absorbed energy into heat and using Yb3+ , Er3+-NaYF 4 phosphors to monitor the temperature inside the tumor. Our experiments confirm the effectiveness of this strategy, which is expected to be an aid in the development of real-time temperature monitoring and effective photothermal therapy for the treatment of cancers.

Facile synthesis of polypyrrole@metal–organic framework core–shell nanocomposites for dual-mode imaging and synergistic chemo-photothermal therapy of cancer cells

2017 ◽  
Vol 5 (9) ◽  
pp. 1772-1778 ◽  
Author(s):  
Xiangjun Chen ◽  
Manjie Zhang ◽  
Shengnan Li ◽  
Lu Li ◽  
Lingyu Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cancer Cells ◽  
Photothermal Therapy ◽  
Photoacoustic Imaging ◽  
Metal Organic Framework ◽  
Core Shell ◽  
Dual Mode ◽  
Facile Synthesis ◽  
Metal Organic ◽  
Facile Route

A facile route was developed to fabricate PPy@MOF for dual-mode magnetic resonance/photoacoustic imaging and synergistic chemo-photothermal therapy.

Multifunctional Au@mSiO2/Rhodamine B Isothiocyanate Nanocomposites: Cell Imaging, Photocontrolled Drug Release, and Photothermal Therapy for Cancer Cells

Small ◽  
2012 ◽  
Vol 9 (4) ◽  
pp. 604-612 ◽  
Author(s):  
Zhenlong Jiang ◽  
Biao Dong ◽  
Boting Chen ◽  
Jing Wang ◽  
Lin Xu ◽  
...  
Keyword(s):  
Drug Release ◽  
Cancer Cells ◽  
Rhodamine B ◽  
Photothermal Therapy ◽  
Cell Imaging ◽  
Rhodamine B Isothiocyanate

Organic molecules with propeller structures for efficient photoacoustic imaging and photothermal ablation of cancer cells

2017 ◽  
Vol 1 (8) ◽  
pp. 1556-1562 ◽  
Author(s):  
Xiaolei Cai ◽  
Jie Liu ◽  
Weng Heng Liew ◽  
Yukun Duan ◽  
Junlong Geng ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Small Molecule ◽  
Photothermal Therapy ◽  
Organic Molecules ◽  
Photoacoustic Imaging ◽  
Organic Nanoparticles ◽  
Photothermal Ablation ◽  
Donor Acceptor

We report organic nanoparticles for efficient photoacoustic imaging and photothermal therapy, based on the small molecule BTPETTQ which has a propeller structure and a donor–acceptor–donor configuration.

scholarly journals Multifunctional NaYF4:Yb3+,Er3+@SiO2@Au heterogeneous nanocomposites for upconversion luminescence, temperature sensing and photothermal conversion

RSC Advances ◽  
2017 ◽  
Vol 7 (19) ◽  
pp. 11491-11495 ◽  
Author(s):  
Dongdong Li ◽  
Wen-Yong Lai ◽  
Qiyue Shao ◽  
Wei Huang
Keyword(s):  
Real Time ◽  
Photothermal Therapy ◽  
Upconversion Luminescence ◽  
Temperature Monitoring ◽  
Temperature Sensing ◽  
Photothermal Conversion

NaYF4:Yb3+,Er3+@SiO2@Au heterogeneous nanostructures, with the ability of integrating upconversion luminescence, photothermal therapy and real-time temperature monitoring, have been successfully prepared.

Synthesis and Characterization of ROSA Dye - A Rhodamine B-type Fluorophore, Suitable for Bioconjugation and Fluorescence Studies in Live Cells

2019 ◽  
Vol 26 (10) ◽  
pp. 758-767
Author(s):  
Vicente Rubio ◽  
Vijaya Iragavarapu ◽  
Maciej J. Stawikowski
Keyword(s):  
Quantum Yield ◽  
Cancer Cells ◽  
Fluorescent Probe ◽  
Extinction Coefficient ◽  
Rhodamine B ◽  
Solid Phase ◽  
Total Yield ◽  
Molar Extinction Coefficient ◽  
Αvβ3 Integrin ◽  
Αvβ3 Integrins

Background: Herein we report the multigram-scale synthesis, characterization and application of a rhodamine B-based fluorophore (ROSA) suitable for fluorescent studies in biological applications. This fluorophore is devoid of rhodamine spirolactone formation and furthermore characterized by a high molar extinction coefficient (ϵ=87250 ± 1630 M-1cm-1) and quantum yield (φ) of 0.589 ± 0.070 in water. Reported here is also the application of ROSA towards synthesis of a ROSA-PEG-GRGDS-NH2 fluorescent probe suitable for live cell imaging of αvβ3 integrins for in vitro assays. Objective: The main objective of this study is to efficiently prepare rhodamine B derivative, devoid of spirolactone formation that would be suitable for bioconjugation and subsequent bioimaging. Methods: Rhodamine B was transformed into rhodamine B succinimide ester (RhoB-OSu) using N-hydroxysuccinimide. RhoB-OSu was further coupled to sarcosine to obtain rhodamine Bsarcosine dye (ROSA) in good yield. The ROSA dye was then coupled to a αvβ3 integrin binding sequence using standard solid-phase conditions. Resulting ROSA-PEG-GRGDS-NH2 probe was used to image integrins on cancer cells. Results: The rhodamine B-sarcosine dye (ROSA) was obtained in multigram scale in good total yield of 47%. Unlike rhodamine B, the ROSA dye does not undergo pH-dependent spirolactone/spirolactam formation as compared with rhodamine B-glycine. It is also characterized by excellent quantum yield (φ) of 0.589 ± 0.070 in water and high molar extinction coefficient of 87250 ± 1630 M-1cm-1. ROSA coupling to the RGD-like peptide was proved to be efficient and straightforward. Imaging using standard filters on multimode plate reader and confocal microscope was performed. The αvβ3 integrins present on the surface of live WM-266-4 (melanoma) and MCF- 7 (breast cancer) cells were successfully imaged. Conclusion: We successfully derivatized rhodamine B to create an inexpensive, stable and convenient to use fluorescent probe. The obtained derivative has excellent photochemical properties and it is suitable for bioconjugation and many imaging applications.

Single-chain antibody-decorated Au nanocages@liposomal layer nanoprobes for targeted SERS imaging and remote-controlled photothermal therapy of melanoma cancer cells

2021 ◽  
Vol 124 ◽  
pp. 112086
Author(s):  
Ghazal Farahavar ◽  
Samira Sadat Abolmaali ◽  
Foroogh Nejatollahi ◽  
Amin Safaie ◽  
Sanaz Javanmardi ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Photothermal Therapy ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Melanoma Cancer ◽  
Sers Imaging
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