scholarly journals Spermine amides of selected triterpenoid acids: dynamic supramolecular system formation influences the cytotoxicity of the drugs

2020 ◽  
Vol 8 (3) ◽  
pp. 484-491 ◽  
Author(s):  
Uladzimir Bildziukevich ◽  
Matěj Malík ◽  
Zulal Özdemir ◽  
Lucie Rárová ◽  
Lucie Janovská ◽  
...  
Keyword(s):  
Self Assembly ◽  
Supramolecular System ◽  
Helical Structures ◽  
Low Contrast ◽  
System Formation

Cytotoxicity data: 8a: IC50 [μM]: 18.8/31.8/32.6/17.2 (25.1 ± 8.2), due to the dynamic self-assembly found, low-contrast networks (TEM); 8b: IC50 [μM]: 7.5 ± 1.6, dynamic self-assembly not detected, partly helical structures (TEM).

scholarly journals Controlling the length of porphyrin supramolecular polymers via coupled equilibria and dilution-induced supramolecular polymerization

2022 ◽  
Vol 13 (1) ◽  
Author(s):  
Elisabeth Weyandt ◽  
Luigi Leanza ◽  
Riccardo Capelli ◽  
Giovanni M. Pavan ◽  
Ghislaine Vantomme ◽  
...  
Keyword(s):  
Complex Systems ◽  
Self Assembly ◽  
Chiral Discrimination ◽  
Coarse Grained ◽  
Supramolecular Polymers ◽  
Supramolecular System ◽  
Precise Control ◽  
Aggregate Morphology ◽  
The Individual ◽  
Supramolecular Polymerization

AbstractMulti-component systems often display convoluted behavior, pathway complexity and coupled equilibria. In recent years, several ways to control complex systems by manipulating the subtle balances of interaction energies between the individual components have been explored and thereby shifting the equilibrium between different aggregate states. Here we show the enantioselective chain-capping and dilution-induced supramolecular polymerization with a Zn2+-porphyrin-based supramolecular system when going from long, highly cooperative supramolecular polymers to short, disordered aggregates by adding a monotopic Mn3+-porphyrin monomer. When mixing the zinc and manganese centered monomers, the Mn3+-porphyrins act as chain-cappers for Zn2+-porphyrin supramolecular polymers, effectively hindering growth of the copolymer and reducing the length. Upon dilution, the interaction between chain-capper and monomers weakens as the equilibria shift and long supramolecular polymers form again. This dynamic modulation of aggregate morphology and length is achieved through enantioselectivity in the aggregation pathways and concentration-sensitive equilibria. All-atom and coarse-grained molecular simulations provide further insights into the mixing of the species and their exchange dynamics. Our combined experimental and theoretical approach allows for precise control of molecular self-assembly and chiral discrimination in complex systems.

A single-step multi-level supramolecular system for cancer sonotheranostics

2019 ◽  
Vol 4 (1) ◽  
pp. 190-195 ◽  
Author(s):  
Huirong Lin ◽  
Shuang Li ◽  
Junqing Wang ◽  
Chengchao Chu ◽  
Yang Zhang ◽  
...  
Keyword(s):  
Self Assembly ◽  
Single Step ◽  
Supramolecular System ◽  
Therapeutic Effects ◽  
Invasive Approach ◽  
Non Invasive ◽  
Ionic Crosslinking ◽  
Critical Issues ◽  
Multi Level

A multi-level supramolecular system produced by single-step Fe3+-mediated ionic crosslinking self-assembly can overcome the critical issues of current sonodynamic therapy (SDT) and address the need to monitor therapeutic effects in vivo with a non-invasive approach.

Tunable multi-color luminescence from a self-assembled cyanostilbene and cucurbit[7]uril in aqueous media

2020 ◽  
Vol 56 (4) ◽  
pp. 655-658 ◽  
Author(s):  
Shubhra Kanti Bhaumik ◽  
Supratim Banerjee
Keyword(s):  
Self Assembly ◽  
Aqueous Media ◽  
The Self ◽  
Supramolecular System ◽  
Self Assembled ◽  
Guest Chemistry

A tunable multicolor luminescent supramolecular system was designed in aqueous media employing the self-assembly of a cationic amphiphilic cyanostilbene and the host–guest chemistry of cucurbit[7]uril.

A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly

2020 ◽  
Vol 56 (11) ◽  
pp. 1629-1632
Author(s):  
Yu Zhao ◽  
Jiawen Zou ◽  
Yanyan Song ◽  
Jun Peng ◽  
Yi Wang ◽  
...  
Keyword(s):  
Biological Samples ◽  
Self Assembly ◽  
Dipeptidyl Peptidase ◽  
Fluorescence Assay ◽  
Supramolecular System ◽  
Label Free ◽  
Activity Detection ◽  
Inhibitor Screening ◽  
Dipeptidyl Peptidase 4

A novel supramolecular system CB[7]-GPFG for dipeptidyl peptidase 4 (DPP4) activity detection in biological samples and inhibitor screening.

scholarly journals α-Helical Structures Drive Early Stages of Self-Assembly of Amyloidogenic Amyloid Polypeptide Aggregate Formation in Membranes

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Martina Pannuzzo ◽  
Antonio Raudino ◽  
Danilo Milardi ◽  
Carmelo La Rosa ◽  
Mikko Karttunen
Keyword(s):  
Self Assembly ◽  
Aggregate Formation ◽  
Helical Structures ◽  
Early Stages

Rational Design of a Ternary Supramolecular System: Self-Assembly of Pentanuclear Lanthanide Helicates

2011 ◽  
Vol 133 (28) ◽  
pp. 10764-10767 ◽  
Author(s):  
Badr El Aroussi ◽  
Soumaila Zebret ◽  
Céline Besnard ◽  
Philippe Perrottet ◽  
Josef Hamacek
Keyword(s):  
Self Assembly ◽  
Rational Design ◽  
Supramolecular System

Self-assembly of near-unity helical Ce1−xMxO2 (x = 0.1, M = Ni and Bi) solid solutions with tunable optical activity

2018 ◽  
Vol 42 (3) ◽  
pp. 1577-1580
Author(s):  
Jing Chen ◽  
Songmei Li ◽  
Juan Du ◽  
Jianhua Liu ◽  
Mei Yu ◽  
...  
Keyword(s):  
Optical Activity ◽  
Solid Solutions ◽  
Self Assembly ◽  
Visible Range ◽  
Helical Structures ◽  
Exciton Coupling ◽  
Left Handed ◽  
Uv Visible

Ce1−xMxO2 solid solutions show tunable optical activity throughout the whole UV–visible range ascribed to electronic exciton coupling between left-handed helical structures.

Absolute Asymmetric Catalysis, from Concept to Experiment: A Narrative

Synlett ◽  
2021 ◽  
Author(s):  
Joaquim Crusats ◽  
Albert Moyano
Keyword(s):  
Asymmetric Catalysis ◽  
Self Assembly ◽  
Mirror Symmetry ◽  
Dissipative Structures ◽  
The Self ◽  
Supramolecular System ◽  
Alternative Mechanism ◽  
Experimental Realization ◽  
Molecular Systems ◽  
Catalytically Active

In order to explain the origin of the single-handedness of the molecules of life (biological homochirality), the appearence of an initial enantiomeric imbalance by spontaneous mirror-symmetry breaking (SMSB) in prebiotic reactions is usually assumed, but examples of its experimental realization are very scarce. SMSB in the self-assembly of achiral molecules is much more common, and the chirality sign of the resulting supramolecular system can be controlled by the action of macroscopic chiral forces. We have proposed a new mechanism for the generation of net chirality in molecular systems, in which the SMSB takes place in the formation of chiral supramolecular dissipative structures from achiral monomers, leading to asymmetric imbalances in their composition that are subsequently transferred to a standard enantioselective catalytic reaction, dodging in this way the highly limiting requirement of finding suitable reactions in solution that show enantioselective autocatalysis. We propose the name “absolute asymmetric catalysis” for this approach, in which an achiral monomer is converted to a nonracemic chiral aggregate that is generated with SMSB and that is catalytically active. We present in this Account a step-by-step narrative of the development of this prebiotically plausible, alternative mechanism for the emergence of net chirality in molecular reactions.

scholarly journals Color-tunable single-fluorophore supramolecular system with assembly-encoded emission

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Qian Wang ◽  
Qi Zhang ◽  
Qi-Wei Zhang ◽  
Xin Li ◽  
Cai-Xin Zhao ◽  
...  
Keyword(s):  
Self Assembly ◽  
Light Emission ◽  
Dynamic Properties ◽  
Supramolecular System ◽  
Fluorescent Properties ◽  
Aromatic Stacking ◽  
Color Tunable ◽  
Research Goal ◽  
Fundamental Research ◽  
Emission System

AbstractRegulating the fluorescent properties of organic small molecules in a controlled and dynamic manner has been a fundamental research goal. Although several strategies have been exploited, realizing multi-color molecular emission from a single fluorophore remains challenging. Herein, we demonstrate an emissive system by combining pyrene fluorophore and acylhydrazone units, which can generate multi-color switchable fluorescent emissions at different assembled states. Two kinds of supramolecular tools, amphiphilic self-assembly and γ-cyclodextrin mediated host-guest recognition, are used to manipulate the intermolecular aromatic stacking distances, resulting in the tunable fluorescent emission ranging from blue to yellow, including a pure white-light emission. Moreover, an external chemical signal, amylase, is introduced to control the assembly states of the system on a time scale, generating a distinct dynamic emission system. The dynamic properties of this multi-color fluorescent system can be also enabled in a hydrogel network, exhibiting a promising potential for intelligent fluorescent materials.

Sign in / Sign up

Export Citation Format

Share Document