Glucose-functionalized near-infrared Ag2Se quantum dots with renal excretion ability for long-term in vivo tumor imaging

2019 ◽  
Vol 7 (38) ◽  
pp. 5782-5788 ◽  
Author(s):  
Xiao-Lei Ge ◽  
Biao Huang ◽  
Zhi-Ling Zhang ◽  
Xiaolan Liu ◽  
Man He ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Fluorescent Probes ◽  
Near Infrared ◽  
Renal Excretion ◽  
Tumor Imaging

Non-toxic and long-term fluorescent probes for tumor imaging are in urgent need for non-invasively obtaining information about tumor genesis and metastasis in vivo.

scholarly journals Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging

2019 ◽  
Vol 95 (5) ◽  
pp. 475-489
Author(s):  
Mona Doshi ◽  
Daniel A. Nierenberg ◽  
Orielyz Flores-Fernandez ◽  
Pragney Deme ◽  
Edilu Becerra ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Tumor Imaging

Revealing the biodistribution and clearance of Ag2Se near-infrared quantum dots in mice

2017 ◽  
Vol 41 (21) ◽  
pp. 12721-12725 ◽  
Author(s):  
Xiao-Lei Ge ◽  
Zhi-Ling Zhang ◽  
Zhi-Xiong Xie ◽  
Ran Cui ◽  
Dai-Wen Pang
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Renal Excretion

Ultra-small Ag2Se QDs can be cleared from the mice body mostly by renal excretion without significant long-term organ accumulation.

Biocompatible Near-Infrared Quantum Dots as Ultrasensitive Probes for Long-Term in vivo Imaging Applications

Small ◽  
2009 ◽  
Vol 5 (17) ◽  
pp. 1997-2004 ◽  
Author(s):  
Ken-Tye Yong ◽  
Indrajit Roy ◽  
Hong Ding ◽  
Earl J. Bergey ◽  
Paras N. Prasad
Keyword(s):  
Quantum Dots ◽  
In Vivo Imaging ◽  
Near Infrared

A lysosome specific, acidic-pH activated, near-infrared Bodipy fluorescent probe for noninvasive, long-term, in vivo tumor imaging

2020 ◽  
Vol 111 ◽  
pp. 110762 ◽  
Author(s):  
Nandi Chen ◽  
Harikrishna Kommidi ◽  
Hua Guo ◽  
Amy P. Wu ◽  
Ziming Zhang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Acidic Ph

scholarly journals Ultrasmall Near-Infrared Non-cadmium Quantum Dots for in vivo Tumor Imaging

Small ◽  
2010 ◽  
Vol 6 (2) ◽  
pp. 256-261 ◽  
Author(s):  
Jinhao Gao ◽  
Kai Chen ◽  
Renguo Xie ◽  
Jin Xie ◽  
Seulki Lee ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Tumor Imaging

scholarly journals Design of bright near-infrared-emitting quantum dots capped with different stabilizing ligands for tumor targeting

RSC Advances ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 4221-4229 ◽  
Author(s):  
Xijing Liu ◽  
Peijiang Zhou ◽  
Hongyu Liu ◽  
Hongju Zhan ◽  
Qiang Zhang ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Diagnosis And Therapy ◽  
Stabilizing Ligands

Advanced research into biocompatible NIR-emitting QDs provides significant promise for long-term diagnosis and therapy through in vivo observations.

Synthesis of NAC capped near infrared-emitting CdTeS alloyed quantum dots and application for in vivo early tumor imaging

2012 ◽  
Vol 41 (16) ◽  
pp. 4935 ◽  
Author(s):  
Bing Xue ◽  
Da-Wei Deng ◽  
Jie Cao ◽  
Fei Liu ◽  
Xin Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Early Tumor

Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

2021 ◽  
Author(s):  
Xiao Liu ◽  
Xiangyang Gong ◽  
Jie Yuan ◽  
Xiaopeng Fan ◽  
Xingxing Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Stimulus Responsive

scholarly journals Time-Programmed Delivery of Sorafenib and Anti-CD47 Antibody via a Double-Layer-Gel Matrix for Postsurgical Treatment of Breast Cancer

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Liping Huang ◽  
Yiyi Zhang ◽  
Yanan Li ◽  
Fanling Meng ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Near Infrared ◽  
Immune Escape ◽  
Regulatory Protein ◽  
In Vivo Studies ◽  
Breast Cancer Patients ◽  
Thermally Responsive ◽  
Immunosuppressive Microenvironment

AbstractThe highly immunosuppressive microenvironment after surgery has a crucial impact on the recurrence and metastasis in breast cancer patients. Programmable delivery of immunotherapy-involving combinations through a single drug delivery system is highly promising, yet greatly challenging, to reverse postoperative immunosuppression. Here, an injectable hierarchical gel matrix, composed of dual lipid gel (DLG) layers with different soybean phosphatidylcholine/glycerol dioleate mass ratios, was developed to achieve the time-programmed sequential delivery of combined cancer immunotherapy. The outer layer of the DLG matrix was thermally responsive and loaded with sorafenib-adsorbed graphene oxide (GO) nanoparticles. GO under manually controlled near-infrared irradiation generated mild heat and provoked the release of sorafenib first to reeducate tumor-associated macrophages (TAMs) and promote an immunogenic tumor microenvironment. The inner layer, loaded with anti-CD47 antibody (aCD47), could maintain the gel state for a much longer time, enabling the sustained release of aCD47 afterward to block the CD47-signal regulatory protein α (SIRPα) pathway for a long-term antitumor effect. In vivo studies on 4T1 tumor-bearing mouse model demonstrated that the DLG-based strategy efficiently prevented tumor recurrence and metastasis by locally reversing the immunosuppression and synergistically blocking the CD47-dependent immune escape, thereby boosting the systemic immune responses.

Near-infrared persistent luminescence hollow mesoporous nanospheres for drug delivery and in vivo renewable imaging

2016 ◽  
Vol 4 (48) ◽  
pp. 7845-7851 ◽  
Author(s):  
Junpeng Shi ◽  
Meng Sun ◽  
Xia Sun ◽  
Hongwu Zhang
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
High Sensitivity ◽  
Drug Carriers ◽  
Template Method ◽  
Persistent Luminescence ◽  
Deep Tissue ◽  
Large Capacity

Near-infrared persistent luminescence hollow mesoporous nanospheres have been synthesized via a template method. These nanospheres can be used as large capacity drug carriers and realize super long-term and high sensitivity tracking of drug delivery in deep tissue.

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