scholarly journals Novel four-disulfide insulin analog with high aggregation stability and potency

2020 ◽  
Vol 11 (1) ◽  
pp. 195-200 ◽  
Author(s):  
Xiaochun Xiong ◽  
Alan Blakely ◽  
Prasoona Karra ◽  
Michael A. VandenBerg ◽  
Gabrielle Ghabash ◽  
...  
Keyword(s):  
Insulin Analog ◽  
Aggregation Stability

A novel four-disulfide insulin analog was designed with retained bioactivity and increased fibrillation stability.

237-OR: Insulin Icodec: An Insulin Analog Suited for Once-Weekly Dosing in Type 2 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 237-OR ◽  
Author(s):  
ULRIKE HÖVELMANN ◽  
LISE BRØNDSTED ◽  
NIELS R. KRISTENSEN ◽  
RASMUS RIBEL-MADSEN ◽  
J. HANS DEVRIES ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Analog

scholarly journals A Biologically Active Insulin Analog with an Enlarged Intrachain Cyclic System

1973 ◽  
Vol 248 (21) ◽  
pp. 7304-7309
Author(s):  
Alexandros Cosmatos ◽  
Panayotis G. Katsoyannis
Keyword(s):  
Biologically Active ◽  
Insulin Analog ◽  
Cyclic System

Systemic allergic reaction by a human insulin analog

Allergy ◽  
2003 ◽  
Vol 58 (6) ◽  
pp. 536-537 ◽  
Author(s):  
R. Barranco ◽  
T. Herrero ◽  
P. Tornero ◽  
M. Barrio ◽  
C. Frutos ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Human Insulin ◽  
Insulin Analog ◽  
Systemic Allergic Reaction

Late-onset lipoatrophic diabetes. Phenotypic and genotypic familial studies and effect of treatment with metformin and lispro insulin analog

Diabetes Care ◽  
1999 ◽  
Vol 22 (8) ◽  
pp. 1374-1376 ◽  
Author(s):  
M. C. Vantyghem ◽  
C. Vigouroux ◽  
J. Magre ◽  
C. Desbois-Mouthon ◽  
F. Pattou ◽  
...  
Keyword(s):  
Late Onset ◽  
Insulin Analog ◽  
Lipoatrophic Diabetes ◽  
Lispro Insulin ◽  
Effect Of Treatment

scholarly journals Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo

Diabetes Care ◽  
2000 ◽  
Vol 23 (5) ◽  
pp. 644-649 ◽  
Author(s):  
L. Heinemann ◽  
R. Linkeschova ◽  
K. Rave ◽  
B. Hompesch ◽  
M. Sedlak ◽  
...  
Keyword(s):  
Insulin Glargine ◽  
Insulin Analog ◽  
Nph Insulin ◽  
Acting Insulin ◽  
Analog Insulin ◽  
Long Acting ◽  
Action Profile

A questionnaire survey on the use of quick-acting insulin analog in Japanese children and adolescents with type 1 diabetes

2004 ◽  
Vol 46 (3) ◽  
pp. 285-290 ◽  
Author(s):  
Tatsuhiko Urakami ◽  
Tomoyuki Kawamura ◽  
Shigetaka Sugihara ◽  
Shigeki Miyamoto ◽  
Shin Amemiya ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Questionnaire Survey ◽  
Insulin Analog ◽  
Japanese Children ◽  
Acting Insulin

scholarly journals The Effect of High-Dose Insulin Analog Initiation Therapy on Lipid Peroxidation Products and Oxidative Stress Markers in Type 2 Diabetic Patients

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Hazal Tuzcu ◽  
Ibrahim Aslan ◽  
Mutay Aslan
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Blood Glucose ◽  
Glucose Variability ◽  
Insulin Analog ◽  
High Dose ◽  
Oxidative Stress Markers ◽  
Insulin Analogs ◽  
Stress Markers ◽  
Mean Blood Glucose

Effect of high-dose insulin analog initiation therapy was evaluated on lipid peroxidation and oxidative stress markers in type 2 diabetes mellitus (T2DM). Twenty-four T2DM patients with HbA1c levels above 10% despite ongoing therapy with sulphonylurea and metformin were selected. Former treatment regimen was continued for the first day followed by substitution of sulphonylurea therapy with different insulin analogs. Glycemic profiles were determined over 72 hours by Continuous Glucose Monitoring System (CGMS), and blood/urine samples were collected at 24 and 72 hours. Insulin analog plus metformin treatment significantly reduced glucose variability. Plasma and urine lipid peroxidation were markedly decreased following insulin analog plus metformin treatment. No correlation existed between glucose variability and levels of plasma and urine oxidative stress markers. Likewise, changes in mean blood glucose from baseline to end point showed no significant correlation with changes in markers of oxidative stress. On the contrary, decreased levels of oxidative stress markers following treatment with insulin analogs were significantly correlated with mean blood glucose levels. In conclusion, insulin plus metformin resulted in a significant reduction in oxidative stress markers compared with oral hypoglycemic agents alone. Data from this study suggests that insulin analogs irrespective of changes in blood glucose exert inhibitory effects on free radical formation.

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