scholarly journals Desymmetrization of cyclic 1,3-diketones via Ir-catalyzed hydrogenation: an efficient approach to cyclic hydroxy ketones with a chiral quaternary carbon

2019 ◽  
Vol 10 (25) ◽  
pp. 6350-6353 ◽  
Author(s):  
Quan Gong ◽  
Jialin Wen ◽  
Xumu Zhang
Keyword(s):  
Efficient Method ◽  
Quaternary Carbon ◽  
Efficient Approach ◽  
Quaternary Center ◽  
Hydroxy Ketones

We herein report an efficient method to synthesize cyclic hydroxy ketones with a chiral quaternary center.

Asymmetric tandem conjugate addition–protonation to forge chiral secondary C–O bonds for quaternary carbon stereocenters at the nonadjacent β-position

2017 ◽  
Vol 53 (54) ◽  
pp. 7493-7496 ◽  
Author(s):  
San-Ni Hong ◽  
Yang Liu ◽  
Richmond Lee ◽  
Zhiyong Jiang
Keyword(s):  
Conjugate Addition ◽  
Quaternary Carbon ◽  
Efficient Approach

The first asymmetric tandem conjugate addition–protonation to methylene 1,3-oxazolidine-2,4-diones has been developed, thus providing a direct and efficient approach to assemble chiral secondary C–O bonds for quaternary carbon stereocenters and thiols at the nonadjacent β-position.

Efficient Synthesis of Chromenes from Vinyl o-Quinone Methides via a Brønsted Acid Catalyzed Electrocyclization Process

Synthesis ◽  
2018 ◽  
Vol 50 (12) ◽  
pp. 2416-2422 ◽  
Author(s):  
Man-Su Tu ◽  
Guang-Jian Mei ◽  
Feng Shi ◽  
Si-Jia Liu ◽  
Xiao-Li Jiang ◽  
...  
Keyword(s):  
Efficient Method ◽  
Research Area ◽  
Environmentally Benign ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Quinone Methides ◽  
Efficient Approach ◽  
Brönsted Acid ◽  
Acid Catalyzed

An efficient approach for the synthesis of chromene derivatives from vinyl o-quinone methides was established via a Brønsted acid catalyzed electrocyclization. By using this methodology, a series of structurally diversified chromenes was synthesized in a highly atom-economic and environmentally benign manner with generally good to excellent yields (up to 98% yield). This reaction will not only provide an efficient method for the construction of chromene scaffolds, but also enrich the research area of o-quinone methides.

scholarly journals Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of congested deuterium-labeled arenes

2019 ◽  
Vol 55 (59) ◽  
pp. 8567-8570 ◽  
Author(s):  
Lei Guo ◽  
Chen Xu ◽  
Ding-Chuan Wu ◽  
Guang-Qi Hu ◽  
Hong-Hai Zhang ◽  
...  
Keyword(s):  
Efficient Method ◽  
Efficient Approach ◽  
Aryl Iodides

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed.

DABCO-catalyzed ring opening of activated cyclopropanes and recyclization leading to γ-lactams with an all-carbon quaternary center

2014 ◽  
Vol 50 (72) ◽  
pp. 10491-10494 ◽  
Author(s):  
Shaoxia Lin ◽  
Ling Li ◽  
Fushun Liang ◽  
Qun Liu
Keyword(s):  
Efficient Method ◽  
Ring Opening ◽  
Quaternary Center

A novel and efficient method for the construction of γ-lactams with an all-carbon quaternary center is developed via a DABCO-catalyzed reaction of EWG-activated cyclopropanecarboxamides and electron-deficient alkenes.

An efficient method to transcription factor binding sites imputation via simultaneous completion of multiple matrices with positional consistency

2017 ◽  
Vol 13 (9) ◽  
pp. 1827-1837 ◽  
Author(s):  
Wei-Li Guo ◽  
De-Shuang Huang
Keyword(s):  
Transcription Factor ◽  
Efficient Method ◽  
Binding Sites ◽  
Transcription Factor Binding Sites ◽  
Transcription Factor Binding ◽  
Tensor Completion ◽  
Factor Binding ◽  
Efficient Approach

The tensor completion-based method is a novel and efficient approach for the imputation of transcription factor binding sites.

Doyle-Kirmse Reaction Using 3,3-Difluoroallyl Sulfide and N-Sulfonyl-1,2,3-triazole: An Efficient Access to gem-Difluoroallylated Multifunctional Quaternary Carbon

2021 ◽  
Author(s):  
Jiazhuang Wang ◽  
Jingwen Yu ◽  
Junyu Chen ◽  
Yubo Jiang ◽  
Tiebo Xiao
Keyword(s):  
Sigmatropic Rearrangement ◽  
Quaternary Carbon ◽  
Quaternary Center ◽  
Efficient Access

Doyle-Kirmse reaction of N-sulfonyl-1,2,3-triazole with 3,3-difluoroallyl sulfide through Rh(II)-catalyzed [2,3]-sigmatropic rearrangement has been developed, which affords an efficient access to multifunctional quaternary center containing aryl, imino, thio, and brominated gem-difluoroallyl....

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