scholarly journals Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe

2019 ◽  
Vol 10 (13) ◽  
pp. 3715-3722 ◽  
Author(s):  
Donglei Shi ◽  
Shuqiang Chen ◽  
Biao Dong ◽  
Yanhui Zhang ◽  
Chunquan Sheng ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Anticancer Agents ◽  
Dual Mode ◽  
First Time

Probe C7 for the first time presents different modes of fluorescence signals to both nanomolar and micromolar concentrations of HOCl.

Engineering dithiobenzoic acid lactone-decorated Si-rhodamine as a highly selective near-infrared HOCl fluorescent probe for imaging drug-induced acute nephrotoxicity

2019 ◽  
Vol 55 (73) ◽  
pp. 10916-10919 ◽  
Author(s):  
Jinping Wang ◽  
Dan Cheng ◽  
Longmin Zhu ◽  
Peng Wang ◽  
Hong-Wen Liu ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Near Infrared ◽  
Drug Induced ◽  
Acid Lactone ◽  
First Time

A NIR fluorescent probe based on Si-rhodamine dithiobenzoic acid lactone was used to selectively visualize HOCl during GEN-induced nephrotoxicity for the first time.

A dual-mode colorimetric/fluorescent probe based on perylene: Response to acidic pH values

2021 ◽  
Author(s):  
Liu Yang ◽  
Yan Liu ◽  
Ping Li ◽  
Yu-Long Liu ◽  
Xiao-Min Liang ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Acidic Ph ◽  
Dual Mode ◽  
Ph Values

Design, synthesis and evaluation of structurally diverse ortho-acylphenol-diindolylmethane hybrids as anticancer agents

2022 ◽  
Author(s):  
Zhi-Gang Yin ◽  
Xiong-Wei Liu ◽  
Hui-Juan Wang ◽  
Min Zhang ◽  
Xiong-Li Liu ◽  
...  
Keyword(s):  
Carboxylic Acid ◽  
Anticancer Agents ◽  
Nucleophilic Addition ◽  
Ring Opening ◽  
Building Blocks ◽  
Efficient Synthesis ◽  
Design Synthesis ◽  
Pyrone Ring ◽  
Ring Opening Reaction ◽  
First Time

A highly efficient synthesis of structurally diverse ortho-acylphenol–diindolylmethane hybrids 3 using carboxylic acid-activated chromones as versatile synthetic building blocks is reported here for the first time, through 1,4-nucleophilic addition and followed by a decarboxylation and pyrone ring opening reaction process.

A fluorescent probe for relay recognition of homocysteine and Group IIIA ions including Ga(iii)

2016 ◽  
Vol 52 (4) ◽  
pp. 827-830 ◽  
Author(s):  
Ya-Wen Wang ◽  
Shun-Bang Liu ◽  
Wei-Jian Ling ◽  
Yu Peng
Keyword(s):  
Fluorescent Probe ◽  
First Time

Relay fluorescence recognition of homocysteine and gallium ions was realized by sequential chemodosimeter and chemosensor approaches for the first time.

scholarly journals Chemical Constituents of Eupatorium japonicum and Anti-Inflammatory, Cytotoxic, and Apoptotic Activities of Eupatoriopicrin on Cancer Stem Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Minh Giang Phan ◽  
Thi Thao Do ◽  
Thi Nga Nguyen ◽  
Thi Viet Huong Do ◽  
Ngoc Phuc Dong ◽  
...  
Keyword(s):  
Anticancer Agents ◽  
Human Cancer ◽  
Biological Activities ◽  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
No Production ◽  
Bioactive Constituents ◽  
Anti Inflammatory ◽  
First Time ◽  
Eupatorium Japonicum

Eupatorium japonicum Thunb. of the plant family Asteraceae is a popular traditional herb in Vietnam. However, its chemical constituents as well as bioactive principles have not been investigated yet. We investigated the phytochemistry of E. japonicum in Vietnam and isolated seventeen compounds (1–17) including phytosterols, terpenoids, phenolic acids, flavonoids, fatty alcohols, and fatty acids. They were structurally determined by MS and NMR analysis. Except for compounds 6 and 12, all the other compounds were identified for the first time from E. japonicum. Since many sesquiterpene lactones with α-methylene γ-lactone ring are reported as anti-inflammatory and anticancer agents, eupatoriopicrin (10), 1-hydroxy-8-(4,5-dihydroxytigloyloxy)eudesma-4(15),11(13)-dien-6,12-olide (11) were selected among the isolates for biological assays. Compound 10 was identified as the main bioactive sesquiterpene lactone of E. japonicum showing its potent anti-inflammatory and cytotoxic activity through inhibiting NO production and the growth of HepG2 and MCF-7 human cancer cell lines. For the first time, eupatoriopicrin (10) was demonstrated to strongly inhibit NTERA-2 human cancer stem cell (CSC) line in vitro. It is noticeable that the cytotoxicity of eupatoriopicrin against NTERA-2 cells is mediated by its apoptosis-inducing capability of 10 as demonstrated by the results of Hoechst 33342 staining, flow cytometry apoptosis analysis, and caspase-3 activity assays. The biological activities of the main bioactive constituents 1–7, 10, 12, and 15 supported the reported anti-inflammatory and anticancer properties of extracts from E. japonicum.

A highly sensitive naked-eye fluorescent probe for trace hydrazine based on ‘C-CN’ bond cleavage

The Analyst ◽  
2018 ◽  
Vol 143 (18) ◽  
pp. 4354-4358 ◽  
Author(s):  
Hai Xu ◽  
Zhen Huang ◽  
Yaqian Li ◽  
Biao Gu ◽  
Zile Zhou ◽  
...  
Keyword(s):  
Detection Limit ◽  
Fluorescent Probe ◽  
Water Samples ◽  
Bond Cleavage ◽  
Eye Detection ◽  
Naked Eye ◽  
Real Water Samples ◽  
Highly Sensitive ◽  
First Time ◽  
Naked Eye Detection

The ‘C–CN’ bond cleavage was applied to the recognition of N2H4 for the first time; the obvious change in color could be used for “naked-eye” detection; the corresponding detection limit was found to be 5.81 × 10−8 M (1.65 ppb); the probe could be applied for N2H4 detection in real water samples.

Abstract A48: Novel dual mode fluorine MRI, NIR fluorescent probe for noninvasive detection of tumor-associated inflammation.

2013 ◽  
Author(s):  
Anthony Balducci ◽  
Yi Wen ◽  
Yang Zhang ◽  
Brooke M. Helfer ◽  
Kevin Hitchens ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Noninvasive Detection ◽  
Dual Mode

scholarly journals Xanthohumol, a Prenylated Flavonoid from Hops, Induces DNA Damages in Colorectal Cancer Cells and Sensitizes SW480 Cells to the SN38 Chemotherapeutic Agent

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 932
Author(s):  
Alessandra Scagliarini ◽  
Aline Mathey ◽  
Virginie Aires ◽  
Dominique Delmas
Keyword(s):  
Colorectal Cancer ◽  
Dna Damage ◽  
Anticancer Agents ◽  
Ataxia Telangiectasia Mutated ◽  
Anticancer Compounds ◽  
Dna Damages ◽  
Systematic Screening ◽  
Colorectal Cancer Cells ◽  
Ic50 Values ◽  
First Time

In spite of chemotherapy and systematic screening for people at risk, the mortality rate of colorectal cancer (CRC) remains consistently high, with 600,000 deaths per year. This low success rate in the treatment of CRC results from many failures associated with high resistance and the risk of metastasis. Therefore, in response to these therapeutic failures, new strategies have been under development for several years aimed at increasing the effect of anticancer compounds and/or at reducing their secondary effects on normal cells, thus enabling the host to better withstand chemotherapy. This study highlights that xanthohumol (Xn) concentrations under the IC50 values were able to induce apoptosis and to enhance the DNA-damage response (DDR). We demonstrate for the first time that Xn exerts its anticancer activity in models of colon cancer through activation of the ataxia telangiectasia mutated (ATM) pathway. Subsequently, the ability of Xn to restore DNA damage in CRC cells can sensitize them to anticancer agents such as SN38 (7-ethyl-10-hydroxycamptothecin) used in chemotherapy.

scholarly journals A cephalosporin–chemiluminescent conjugate increases beta-lactamase detection sensitivity by four orders of magnitude

2020 ◽  
Vol 56 (24) ◽  
pp. 3516-3519 ◽  
Author(s):  
Santanu Maity ◽  
Xiaojian Wang ◽  
Subhamoy Das ◽  
Maomao He ◽  
Lee W. Riley ◽  
...  
Keyword(s):  
Fluorescent Probe ◽  
Detection Sensitivity ◽  
Beta Lactamase ◽  
First Time

A beta-lactamase chemiluminescent probe, termed CCP, which can for the first time detect beta-lactamase activity via chemiluminescence and 4-orders of magnitude higher than commercial fluorescent probe.

Design, synthesis and application of a near-infrared fluorescent probe for in vivo imaging of aminopeptidase N

2017 ◽  
Vol 53 (68) ◽  
pp. 9438-9441 ◽  
Author(s):  
Xinyuan He ◽  
Yiming Hu ◽  
Wen Shi ◽  
Xiaohua Li ◽  
Huimin Ma
Keyword(s):  
Fluorescent Probe ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Aminopeptidase N ◽  
Design Synthesis ◽  
First Time

We have, for the first time, developed a near-infrared fluorescent probe for aminopeptidase N by combining a hemicyanine and an alanyl residue.

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