scholarly journals Synergic effect of doxorubicin release and two-photon irradiation of Mn2+-doped Prussian blue nanoparticles on cancer therapy

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2646-2649 ◽  
Author(s):  
Lamiaa M. A. Ali ◽  
Emna Mathlouthi ◽  
Maëlle Cahu ◽  
Saad Sene ◽  
Morgane Daurat ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Prussian Blue ◽  
Cancer Cells ◽  
High Efficiency ◽  
Synergic Effect ◽  
Photon Irradiation ◽  
Two Photon ◽  
Prussian Blue Nanoparticles ◽  
Doxorubicin Release

Mn2+-doped Prussian blue nanoparticles loaded with doxorubicin present high efficiency for combined photothermal and chemotherapy of cancer cells with a synergic effect under two-photon irradiation.

CHARACTERIZATION OF PRUSSIAN BLUE NANOPARTICLES PREPARED BY REVERSE MICELLE AND ELECTROCHEMICAL STUDY OF THEIR ASSEMBLY

2009 ◽  
Vol 16 (04) ◽  
pp. 539-544 ◽  
Author(s):  
JINGXIA QIU ◽  
JIWEI LIU ◽  
KAI SUN ◽  
YUQING MIAO
Keyword(s):  
Prussian Blue ◽  
Reverse Micelle ◽  
High Efficiency ◽  
Electrochemical Study ◽  
Homogeneous Distribution ◽  
Scanning Electronic Microscopy ◽  
Prussian Blue Nanoparticles ◽  
Rapid Formation ◽  
One Step

Well-dispersed Prussian blue (PB) nanoparticles were successfully prepared by reverse micelle. This method is based on one-step rapid formation in different sizes of nano-pool with water/oil system, which leads to a homogeneous distribution of PB nanoparticles. Scanning electronic microscopy, UV–vis, and Fourier infrared spectra give supportive evidence of PB nanoparticles. Electrochemical study shows that PB nanoparticles are modified onto cysteine-assembled Au electrodes and exhibit high efficiency of electron transfer.

scholarly journals Facile synthesis of Prussian blue nanoparticles as pH-responsive drug carriers for combined photothermal-chemo treatment of cancer

RSC Advances ◽  
2017 ◽  
Vol 7 (1) ◽  
pp. 248-255 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Xiaoyi Wu ◽  
Zhengbao Zha
Keyword(s):  
Drug Delivery ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Drug Carriers ◽  
High Efficacy ◽  
Ph Responsive ◽  
Facile Synthesis ◽  
Drug Delivery Vehicles ◽  
Prussian Blue Nanoparticles ◽  
Delivery Vehicles

Multifunctional PEGylated PB-DOX NPs with a lipid-PEG shell were developed as a gram-scale manner and used as novel pH-responsive drug delivery vehicles for combined photothermal-chemo treatment of cancer cells with high efficacy.

Selectively lighting up two-photon photodynamic activity in mitochondria with AIE-active iridium(iii) complexes

2017 ◽  
Vol 53 (12) ◽  
pp. 2052-2055 ◽  
Author(s):  
Jiangping Liu ◽  
Chengzhi Jin ◽  
Bo Yuan ◽  
Xingguo Liu ◽  
Yu Chen ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Multicellular Tumor Spheroids ◽  
Tumor Spheroids ◽  
Photon Irradiation ◽  
Two Photon ◽  
Photodynamic Activity

Three AIE-active Ir(iii) complexes that preferentially accumulate in the mitochondria of cancer cells through endocytosis were manifested in a lit up photodynamic activity in mitochondria with efficient lethality towards cancer cells and multicellular tumor spheroids under two-photon irradiation.

In situ synthesis of Prussian blue nanoparticles within a biocompatible reverse micellar system for in vivo Cs+uptake

2017 ◽  
Vol 41 (8) ◽  
pp. 2887-2890 ◽  
Author(s):  
Cyril Lavaud ◽  
Marilyn Kajdan ◽  
Elsa Compte ◽  
Jean-Claude Maurel ◽  
Joséphine Lai Kee Him ◽  
...  
Keyword(s):  
Prussian Blue ◽  
High Efficiency ◽  
In Situ Synthesis ◽  
Dose Effect ◽  
Micellar System ◽  
Prussian Blue Nanoparticles ◽  
Reverse Micellar System ◽  
Reverse Micellar

A Prussian blue reverse micellar system forin vivoCs+uptake exhibiting high efficiency and a significant dose effect.

Multifunctional phase-change hollow mesoporous Prussian blue nanoparticles as a NIR light responsive drug co-delivery system to overcome cancer therapeutic resistance

2017 ◽  
Vol 5 (34) ◽  
pp. 7051-7058 ◽  
Author(s):  
Huajian Chen ◽  
Yan Ma ◽  
Xianwen Wang ◽  
Zhengbao Zha
Keyword(s):  
Phase Change ◽  
Prussian Blue ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Therapeutic Resistance ◽  
Killing Effect ◽  
Nir Light ◽  
Prussian Blue Nanoparticles ◽  
Delivery Platform ◽  
Cell Killing Effect

A versatile NIR light responsive co-delivery platform of both hydrophobic and hydrophilic anticancer drugs has been developed here for overcoming adaptive therapeutic resistance of cancer cells and enhancing cell-killing effect.

scholarly journals ID: 4001 Nanoparticle-based Cancer Therapy

2017 ◽  
Vol 4 (S) ◽  
pp. 2
Author(s):  
Fuyu Tamanoi
Keyword(s):  
Magnetic Field ◽  
Iron Oxide ◽  
Cancer Therapy ◽  
Cancer Cells ◽  
Anticancer Drugs ◽  
Tumor Targeting ◽  
Two Photon ◽  
Pore Opening ◽  
Oscillating Magnetic Field ◽  
The Way

Advances in Nanotechnology have led to the development of a variety of nanomaterials that are changing the way cancer therapy is carried out. A particularly important example is nanoparticle that can carry cargo to tumor. We are using mesoporous silica nanoparticles (MSNs) for cancer therapy. MSNs contain thousands of pores that provide storage space for anticancer drugs. These materials are biocompatible and safe. In addition, we have recently introduced biodegradability into MSNs.  We have shown that MSNs exhibit excellent tumor targeting capability in two different animal model systems (chicken egg tumor model and mouse xenografts). This tumor targeting capability is partly due to its small size; these nano-sized particles can accumulate in tumor due to leaky tumor vasculature. In addition, we have carried out surface modifications to attach ligands that bind receptors present on the surface of cancer cells. For example, folate was attached to the surface that enables binding to folate receptors overexpressed on cancer cells.  We have also conferred controlled anticancer drug release capability to MSNs in collaboration with Fraser Stoddart and Jeff Zink. This was accomplished by attaching nanovalves at the opening of the pores. Rotaxanes and pseudorotaxanes are used to prepare nanovalves. These chemical compounds consist of a stalk and a moving part. When the moving part is close to the pore opening, the nanovalve is closed. On the other hand, when the moving part is located away from the pore opening, the nanovalve is closed. In this way, the nanovalve provides an open and close function so that controlled release of anticancer drugs can be carried out.  Light activated nanovalves were developed by incorporating azobenzene into nanovalves. Azobenzene changes conformation upon light exposure and this conformational change opens the nanovalve releasing anticancer drugs in a power and exposure time dependent manner. More recently, this system was modified by incorporating two-photon dyes that can capture energy from two-photon light and transfer to azobenzene to drive the release of anticancer drugs. This enables the system to work with tissue penetrating two-photon light.  We have also developed nanoparticles that respond to oscillating magnetic field. This system was developed using MSNs that contain iron oxide core. Because of superparamagnetic property of iron oxide, the internal temperature of such nanoparticles increases when exposed to oscillating magnetic field. This temperature increase drives opening of nanovalves that are particularly designed for this purpose.   Development of nanoparticles that respond to external cues such as light and magnetic field may change the way cancer therapy is carried out. Implications on the future of cancer therapy will be discussed.

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