scholarly journals Aqueous-based electrospun P(NIPAAm-co-AAc)/RSF medicated fibrous mats for dual temperature- and pH-responsive drug controlled release

RSC Advances ◽  
2020 ◽  
Vol 10 (1) ◽  
pp. 323-331 ◽  
Author(s):  
Juan Li ◽  
Jingxin Zhu ◽  
Lan Jia ◽  
Yanlong Ma ◽  
Haijuan Wu
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Ph Responsive ◽  
Drug Controlled Release

This paper presents a green friendly method for preparing dual temperature- and pH-responsive electrospun P(NIPAAm-co-AAc)/RSF fibrous mats for drug release.

A Novel Biodegradable Multichamber Microstructure for Implantable Drug Controlled Release

2010 ◽  
Vol 654-656 ◽  
pp. 2269-2272
Author(s):  
Rui Xia Yu ◽  
Xiang Yang Zhou ◽  
Zeng Zhao
Keyword(s):  
Topology Optimization ◽  
Controlled Release ◽  
Drug Release ◽  
Research Work ◽  
Release Profile ◽  
Drug Release Profile ◽  
Drug Controlled Release ◽  
Simulation Results ◽  
Micro Molding

The research work reported in this paper design a novel biodegradable multichamber microstructure for implantable drug controlled release by introducing the approach of topology optimization. It is therefore highly desirable to overcome these restrictions that pre-defined topology of the device result in difficulty to obtain a linear or pulsed drug release profile. The designed biodegradable multichamber microstructure is fabricated using UV-LIGA microfabrication and Micro-molding technique. The simulation results show that the multichamber microstructure exhibits a preferable linear drug release profile.

scholarly journals Smart Microneedles with Porous Polymer Coatings for pH-Responsive Drug Delivery

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1834 ◽  
Author(s):  
Ullah ◽  
Khan ◽  
Choi ◽  
Kim
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Drug Release ◽  
Sodium Bicarbonate ◽  
Porous Polymer ◽  
Polymer Layer ◽  
Ph Responsive ◽  
Acidic Microenvironment ◽  
Model Drug

: This work demonstrates a simple approach for coating a porous polymer layer on stainless-steel (SS) microneedles characterized by a pH-responsive formulation for self-regulated drug delivery. For many drug-delivery applications, the release of therapeutic agents in an acidic microenvironment is desirable. Acid-sensitive polymers and hydrogels were extensively explored, but easily prepared polymeric microcarriers that combine acid sensitivity and biodegradability are rare. Here, we describe a simple and robust method of coating a porous polymer layer on SS microneedles (MNs) that release a model drug (lidocaine) in a pH-responsive fashion. It was constructed by packing the model drug and a pH-sensitive component (sodium bicarbonate) into the pores of the polymer layer. When this acid-sensitive formulation was exposed to the acidic microenvironment, the consequent reaction of protons (H+) with sodium bicarbonate (NaHCO3) yielded CO2. This effect generated pressure inside the pores of the coating and ruptured the thin polymer membrane, thereby releasing the encapsulated drug. Scanning electron micrographs showed that the pH-sensitive porous polymer-coated MNs exposed to phosphate-buffered saline (PBS) at pH 7.4 were characterized by closed pores. However, MNs exposed to PBS at pH 5.5 consisted of open pores and the thin membrane burst. The in vitro studies demonstrated the pH sensitivity of the drug release from porous polymer-coated MNs. Negligible release was observed for MNs in receiving media at pH 7.4. In contrast, significant release occurred when the MNs were exposed to acidic conditions (pH 5.5). Additionally, comparable results were obtained for drug release in vitro in porcine skin and in PBS. This revealed that our developed pH-responsive porous polymer-coated MNs could potentially be used for the controlled release of drug formulations in an acidic environment. Moreover, the stimuli-responsive drug carriers will enable on-demand controlled release profiles that may enhance therapeutic effectiveness and reduce systemic toxicity.

Preparation and characterization of pullulanase debranched starches and their properties for drug controlled-release

RSC Advances ◽  
2015 ◽  
Vol 5 (117) ◽  
pp. 97066-97075 ◽  
Author(s):  
Guodong Liu ◽  
Yan Hong ◽  
Zhengbiao Gu ◽  
Zhaofeng Li ◽  
Li Cheng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Drug Controlled Release

Linear short amylose and glucan tend to align and aggregate to form hydrogels that hold less water. The drug release properties of debranched starch based tablets can be controlled by the pullulanase modification conditions.

scholarly journals Controlled release evaluation of paracetamol loaded amine functionalized mesoporous silica KCC1 compared to microcrystalline cellulose based tablets

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Marieh Pishnamazi ◽  
Hamid Hafizi ◽  
Mahboubeh Pishnamazi ◽  
Azam Marjani ◽  
Saeed Shirazian ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Microcrystalline Cellulose ◽  
Release Rate ◽  
Drug Carriers ◽  
Release Behavior ◽  
Drug Controlled Release ◽  
Remarkable Effect ◽  
Functionalized Mesoporous Silica

AbstractIn the pharmaceutical manufacturing, drug release behavior development is remained as one of the main challenges to improve the drug effectiveness. Recently, more focus has been done on using mesoporous silica materials as drug carriers for prolonged and superior control of drug release in human body. In this study, release behavior of paracetamol is developed using drug-loaded KCC-1-NH2 mesoporous silica, based on direct compaction method for preparation of tablets. The purpose of this study is to investigate the utilizing of pure KCC-1 mesoporous silica (KCC-1) and amino functionalized KCC-1 (KCC-1-NH2) as drug carriers in oral solid dosage formulations compared to common excipient, microcrystalline cellulose (MCC), to improve the control of drug release rate by manipulating surface chemistry of the carrier. Different formulations of KCC-1 and KCC-NH2 are designed to investigate the effect of functionalized mesoporous silica as carrier on drug controlled-release rate. The results displayed the remarkable effect of KCC-1-NH2 on drug controlled-release in comparison with the formulation containing pure KCC-1 and formulation including MCC as reference materials. The pure KCC-1 and KCC-1-NH2 are characterized using different evaluation methods such as FTIR, SEM, TEM and N2 adsorption analysis.

pH-responsive electrospun nanofibrous membrane for drug controlled release

2013 ◽  
Vol 172 (1) ◽  
pp. e71 ◽  
Author(s):  
Wei Li ◽  
Yang Shi ◽  
Tian Luo ◽  
Siyu Liu ◽  
Li Liu
Keyword(s):  
Controlled Release ◽  
Nanofibrous Membrane ◽  
Ph Responsive ◽  
Drug Controlled Release

P(EO-co-LLA) functionalized Fe3O4@mSiO2 nanocomposites for thermo/pH responsive drug controlled release and hyperthermia

2014 ◽  
Vol 43 (48) ◽  
pp. 18056-18065 ◽  
Author(s):  
Wei Guo ◽  
Chunyu Yang ◽  
Huiming Lin ◽  
Fengyu Qu
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Ph Responsive ◽  
Drug Controlled Release ◽  
Nanoparticle Core

The Fe3O4@mSiO2 nanocarrier that consisted of a magnetic Fe3O4 nanoparticle core and a mesoporous silica (mSiO2) shell was synthesized.

scholarly journals pH-Responsive Micelles Assembled by Three-Armed Degradable Block Copolymers with a Cholic Acid Core for Drug Controlled-Release

Polymers ◽  
2019 ◽  
Vol 11 (3) ◽  
pp. 511 ◽  
Author(s):  
Jingjie Feng ◽  
Weiqiu Wen ◽  
Yong-Guang Jia ◽  
Sa Liu ◽  
and Jianwei Guo
Keyword(s):  
Controlled Release ◽  
Block Copolymers ◽  
Cholic Acid ◽  
Drug Loading ◽  
Ph Responsive ◽  
Triggered Release ◽  
Drug Controlled Release ◽  
Release Studies ◽  
Good Biocompatibility ◽  
Poly Ethylene

One of the most famous anticancer drugs, paclitaxel (PTX), has often been used in drug controlled-release studies. The polymers derived from bio-compound bile acids and degradable poly(ε-caprolactone) (PCL) form a reservoir and have been used as a drug delivery system with great advantages. Herein, we grafted poly(N,N-diethylaminoethyl methacrylate) and poly(poly(ethylene glycol) methyl ether methacrylate) into the bile acid-derived three-armed macroinitiator CA-(PCL)3, resulting in the amphiphilic block copolymers CA-(PCL-b-PDEAEMA-b-PPEGMA)3. These pH-responsive three-armed block copolymers self-assembled into micelles in aqueous solution and PTX was encapsulated into the micellar core to form PTX-loaded micelles with a drug loading of 29.92 wt %. The micelles were stable in PBS at pH 7.4 and showed a pH-triggered release behavior of PTX under acidic environments, in which 55% of PTX was released at pH 5.0 in 80 h. These cholic acid-based functionalized three-armed block polymers present good biocompatibility, showing great potential for drug controlled-release.

Influence of Metal Cations on the Structure and Release Property of Layered Double Hydroxide-Ibuprofen Host-Guest Materials

2010 ◽  
Vol 152-153 ◽  
pp. 556-559 ◽  
Author(s):  
Peng Ding ◽  
Sheng Fu Tang ◽  
Zong Zhou Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Layered Double Hydroxide ◽  
Great Influence ◽  
Metal Cations ◽  
Coprecipitation Method ◽  
Drug Controlled Release ◽  
Release Property ◽  
Double Hydroxide

Layered double hydroxide (LDH)-ibuprofen (IBU) host-guest materials were prepared by in situ coprecipitation method for the purpose of drug controlled release. Three hosts containing different metal cations, MgAl-, ZnAl-, and MgFe-LDH, were studied. The results showed that the types of the metal cations had great influence on the structures of the host-guest materials and thus led to different drug release properities.

Development and Evaluation of Controlled Release Mucoadhesive Tablets of Captopril

1970 ◽  
Vol 9 (3) ◽  
pp. 3318-3329
Author(s):  
Kranthi Kumar Kotta ◽  
L. Srinivas
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Xanthan Gum ◽  
Diffusion Mechanism ◽  
Matrix Tablets ◽  
Fickian Diffusion ◽  
Content Uniformity ◽  
In Vitro Drug Release ◽  
Mucoadhesive Tablets

The present investigation focuses on the development of mucoadhesive tablets of captopril which are designed to prolong the gastric residence time after oral administration. Matrix tablets of captopril were formulated using four mucoadhesive polymers namely guar gum, xanthan gum, HPMC K4M and HPMC K15M and studied for parameters such as weight variation, thickness, hardness, content uniformity, swelling index, mucoadhesive force and in vitro drug release. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M provide slow release of captopril over period of 12 hr and were found suitable for maintenance portion of oral controlled release tablets. The cumulative % of drug release of formulation F9 and F10 were 90 and 92, respectively. In vitro release from these tablets was diffusion controlled and followed zero order kinetics. The ‘n’ values obtained from the pappas-karsemeyer equation suggested that all the formulation showed drug release by non-fickian diffusion mechanism. Tablets formulated Xanthan gum or HPMC K4M with HPMC K15M (1:1) were established to be the optimum formulation with optimum bioadhesive force, swelling index & desired invitro drug release. This product was further subjected to stability study, the results of which indicated no significant change with respect to Adhesive strength and in vitro drug release study.

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