scholarly journals Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p

RSC Advances ◽  
2019 ◽  
Vol 9 (58) ◽  
pp. 33834-33842
Author(s):  
Ying Chen ◽  
Jinxia Hao ◽  
Jing Zhao ◽  
Ye Liu ◽  
Yuan Li ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Plasma Cell ◽  
Plasma Cell Myeloma ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Multiple Myeloma (MM) is a plasma cell myeloma.

scholarly journals Retraction: Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p

RSC Advances ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 6246-6246
Author(s):  
Laura Fisher
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Non Coding Rna ◽  
Ying Chen ◽  
Long Non Coding Rna

Retraction of ‘Long non-coding RNA PCAT1 facilitates cell growth in multiple myeloma through an MTDH-mediated AKT/β-catenin signaling pathway by sponging miR-363-3p’ by Ying Chen et al., RSC Adv., 2019, 9, 33834–33842, DOI: 10.1039/C9RA06188F.

scholarly journals Long non-coding RNA TUG1 knockdown hinders the tumorigenesis of multiple myeloma by regulating the microRNA-34a-5p/NOTCH1 signaling pathway

2020 ◽  
Vol 15 (1) ◽  
pp. 284-295
Author(s):  
Yongtian Zhang ◽  
Dandan Zhao ◽  
Shumei Li ◽  
Meng Xiao ◽  
Hongjing Zhou ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Signaling Pathway ◽  
Notch Receptor ◽  
Cell Counting ◽  
Luciferase Reporter ◽  
Notch1 Signaling ◽  
Non Coding Rna ◽  
Notch1 Signaling Pathway ◽  
Long Non Coding Rna

AbstractMultiple myeloma (MM) is a serious health issue in hematological malignancies. Long non-coding RNA taurine-upregulated gene 1 (TUG1) has been reported to be highly expressed in the plasma of MM patients. However, the functions of TUG1 in MM tumorigenesis along with related molecular basis are still undefined. In this study, increased TUG1 and decreased microRNA-34a-5p (miR-34a-5p) levels in MM tissues and cells were measured by the real-time quantitative polymerase reaction assay. The expression of relative proteins was determined by the Western blot assay. TUG1 knockdown suppressed cell viability, induced cell cycle arrest and cell apoptosis in MM cells, as shown by Cell Counting Kit-8 and flow cytometry assays. Bioinformatics analysis, luciferase reporter assay, and RNA pull-down assay indicated that miR-34a-5p was a target of TUG1 and directly bound to notch receptor 1 (NOTCH1), and TUG1 regulated the NOTCH1 expression by targeting miR-34a-5p. The functions of miR-34a-5p were abrogated by TUG1 upregulation. Moreover, TUG1 loss impeded MM xenograft tumor growth in vivo by upregulating miR-34a-5p and downregulating NOTCH1. Furthermore, TUG1 depletion inhibited the expression of Hes-1, Survivin, and Bcl-2 protein in MM cells and xenograft tumors. TUG1 knockdown inhibited MM tumorigenesis by regulating the miR-34a-5p/NOTCH1 signaling pathway in vitro and in vivo, deepening our understanding of the TUG1 function in MM.

scholarly journals Long non-coding RNA XIST promotes cell growth and metastasis through regulating miR-139-5p mediated Wnt/β-catenin signaling pathway in bladder cancer

Oncotarget ◽  
2017 ◽  
Vol 8 (55) ◽  
pp. 94554-94568 ◽  
Author(s):  
Yangyang Hu ◽  
Chao Deng ◽  
He Zhang ◽  
Jing Zhang ◽  
Bo Peng ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Non Coding Rna ◽  
Long Non Coding Rna

scholarly journals Knockdown of long non-coding RNA H19 inhibits multiple myeloma cell growth via NF-κB pathway

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuanyuan Sun ◽  
Jing Pan ◽  
Ning Zhang ◽  
Wei Wei ◽  
Shanshan Yu ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Myeloma Cell ◽  
Multiple Myeloma Cell ◽  
Non Coding Rna ◽  
Long Non Coding Rna

Long non-coding RNA FEZF1-AS1 promotes cell growth in multiple myeloma via miR-610/Akt3 axis

2018 ◽  
Vol 103 ◽  
pp. 1727-1732 ◽  
Author(s):  
Qian-yu Li ◽  
Li Chen ◽  
Ning Hu ◽  
Hongmian Zhao
Keyword(s):  
Multiple Myeloma ◽  
Cell Growth ◽  
Non Coding Rna ◽  
Long Non Coding Rna
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