scholarly journals Simple synthesis of new imidazopyridinone, pyridopyrimidinone, and thiazolopyridinone derivatives and optimization of reaction parameters using response surface methodology

RSC Advances ◽  
2019 ◽  
Vol 9 (52) ◽  
pp. 30479-30488 ◽  
Author(s):  
Fahimeh Sadat Hosseini ◽  
Mohammad Bayat
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Response Surface Method ◽  
Aromatic Aldehydes ◽  
Simple Synthesis ◽  
Reaction Parameters ◽  
Reaction Conditions ◽  
One Pot ◽  
Surface Method ◽  
The One

The one-pot reaction of various diamines with cysteamine hydrochloride or 1,1-bis(methylthio)-2-nitroethene, aromatic aldehydes, and Meldrum's acid led to pyridone compounds in good yields. The reaction conditions were optimized using response surface method.

Optimization on Influencing Factors of Fracture Toughness of Corundum-Mullite Toughened by In Situ Synthesized Mullite Whiskers by Response Surface Methodology

2012 ◽  
Vol 581-582 ◽  
pp. 819-822 ◽  
Author(s):  
Bin Meng ◽  
Jin Hui Peng
Keyword(s):  
Fracture Toughness ◽  
Response Surface Methodology ◽  
Response Surface ◽  
Response Surface Method ◽  
Sintering Temperature ◽  
Surface Method ◽  
Mullite Whiskers ◽  
Optimized Conditions ◽  
Addition Amount

The corundum-mullite was toughened by in-situ synthesized mullite whiskers and the process parameters influencing the fracture toughness of corundum-mullite, such as sintering temperature, addition amount of AlF3 and V2O5, were optimized by means of response surface method. Corundum-mullite with fracture toughness of 9.44 MPa.m-1/2 could be obtained under the optimized conditions, i.e. sintering temperature of 1400°C, 4.8 wt.% of AlF3 and 5.8 wt.% of V2O5. The results showed that it was feasible to prepare corundum-mullite toughened by in-situ synthesized mullite whiskers by the optimized parameters. In addition, an accurate model based on response surface method was proposed to predict the experimental results.

scholarly journals Modelling and optimization of metals (As, Ca, Cd, Cr, Cu, Fe, Mg, and Pb) and Ethylene glycol butyl ether in paints using response surface method

2021 ◽  
Vol 23 (2) ◽  
pp. 177-190
Author(s):  
A. F. I. Apanpa-Qasim ◽  
A. O. Adeyi ◽  
Sharvari Deshmukh
Keyword(s):  
Experimental Data ◽  
Response Surface Methodology ◽  
Ethylene Glycol ◽  
Response Surface ◽  
Response Surface Method ◽  
Principal Component ◽  
Butyl Ether ◽  
Surface Method ◽  
Principal Component Analyses ◽  
Modelling And Optimization

Response surface methodology (RSM) and principal component analyses (PCA) modelling tools have been used in this study to quantitatively describe the interaction effects of more than one factor on system response for the modelling and optimization of experimental data. In Nigeria, there are no stringent policies in place by the government on paint production and this has led to unregulated paint products by producers in the commercial markets. Water-based paints currently available in Nigerian market were sampled. Experimental data of Metals (As, Ca, Cd, Cr, Cu, Fe, Mg, and Pb) and Ethylene glycol butyl ether (Volatile organic compounds (VOC)) measured using Inductively Coupled Plasma-Optical Emission Spectrometer (ICP-OES) and Gas Chromatography-Flame Ionisation Detector (GC-FID), respectively was used to develop a mathematical model. The principal component analyses were explained with a cumulative variance of 82% for the VOC and 76% for metals based on manufacturers. Estimated responses were compared with the experimentally determined responses and prediction capabilities of Response Surface Methodology. In the RSM, the 2 developed model had R value of 0.9569, with optimized value at 0.10 % (1000ppm) of Ethylene glycol butyl ether and concentration (ppm) ranges of As (383.0-1,930.0), Ca (614.0-10,400.0), Cd (98.0-2,000.0), Cr (10.3- 225.0), Cu (133.0-1,840.0), Fe 742.0-2,910.0, Mg (4,000.0-99,510.0), Pb (170.0-3,230.0). The correlation and optimization study employed are applicable for assessing the impact of hazardous air pollutants on indoor air quality and a good applicability in paint industries to produce products within the set limit of international standards. For the purpose of reducing sick building syndrome and protecting public health, it was important to investigate paints and sealers extensively. Keywords: VOCs; Paint; metals; Ethylene glycol butyl ether; Response Surface Method

Optimization of Condensate Fractionation Unit Using Response Surface Methodology

2014 ◽  
Vol 625 ◽  
pp. 462-465
Author(s):  
Mohammad Taufik Ibrahim ◽  
Nooryusmiza Yusoff
Keyword(s):  
Response Surface Methodology ◽  
Taguchi Method ◽  
Central Composite Design ◽  
Response Surface ◽  
Response Surface Method ◽  
Optimal Configuration ◽  
Base Case ◽  
Surface Method ◽  
Central Composite ◽  
Fractionation Unit

Response Surface Method involving central composite design is employed to determine the optimal configuration of nine factors for maximizing the profit of a Condensate Fractionation Unit. When compared with the results from the base case and Taguchi method, the result from RSM shows higher profits by 33.1% and 1.16%, respectively. A further benefit of 0.64% is noticed when three insignificant factors were removed from the nine-factor experiment due to interactions between factors.

One-pot synthesis of β-amino carbonyl compounds catalyzed silica supported phenylphosphinic acid

2015 ◽  
Vol 4 (1) ◽  
Author(s):  
Di Liu ◽  
Jingwei Zhang ◽  
Chi Zhang ◽  
Xiaoyan Kou
Keyword(s):  
Cost Efficiency ◽  
Carbonyl Compounds ◽  
Aromatic Aldehydes ◽  
Reusable Catalyst ◽  
Reaction Conditions ◽  
One Pot ◽  
Environment Friendly ◽  
Aliphatic Ketones ◽  
One Pot Condensation ◽  
The One

AbstractA simple and facile synthesis of β-amino carbonyl compounds was developed by the one-pot condensation of cyclohexanone, aromatic aldehydes and anilines at 25°C in the presence of silica supported phenylphosphinic acid. β-Amino carbonyl compounds were obtained in moderate to good yields and reasonable diastereoselectivities. This method has the advantages of short reaction time, mild reaction conditions, reusable catalyst, cost efficiency and environment friendly. In addition, acetophenone and aliphatic ketones as reactants were investigated.

scholarly journals Benign Methodology and Efficient Catalysis for the One-Pot Multicomponent Synthesis of Dihydropyrimidinones and Thiones: A New Key for Old Lock

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Parvez Ali ◽  
Naziyanaz Pathan ◽  
Taibi Ben Hadda
Keyword(s):  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Cuprous Chloride ◽  
Atom Economy ◽  
Present Communication ◽  
Multicomponent Synthesis ◽  
Reaction Conditions ◽  
One Pot ◽  
Simple Protocol ◽  
The One

In the present communication, under the influence of microwaves, cuprous chloride has been demonstrated to be safe, mild, efficient, and inexpensive catalyst for the Biginelli discovered multicomponent reaction (MCR) between aromatic aldehydes, urea/substituted urea, and ethyl acetoacetate to produce structurally diverse dihydropyrimidin-2(1H)-ones (DHPMs) and thiones in an ecofriendly solvent-free protocol. The practical and simple protocol led to excellent yields of the dihydropyrimidin-2(1H)-one derivatives under mild reaction conditions and within short span of reaction times with easy reaction workup by maintaining excellent atom economy.

scholarly journals Optimasi Sintesis Ligan Diheksilditiofosfat (DHDTP) Menggunakan Response Surface Method (RSM)

2021 ◽  
Vol 6 (1) ◽  
pp. 285-290
Author(s):  
Diana Hendrati ◽  
Yulia Mardhotillah ◽  
Anni Anggraeni ◽  
M. Lutfi Firdaus ◽  
Santhy Wyantuti
Keyword(s):  
Response Surface ◽  
Response Surface Method ◽  
Mobile Phase ◽  
Ammonium Carbonate ◽  
Synthesis Product ◽  
Reaction Conditions ◽  
Nitrogen Gas ◽  
Reverse Phase Hplc ◽  
Surface Method ◽  
Optimum Reaction

Dihexyldithiophosphate (DHDTP) ligand is one of the homologues of dialkyldithiophosphate which is potentially better as an extractant in solvent extraction. The longer the chain in the dialkyldithophosphate compound, ability to dissolve into the organic phase is increasing compared to the shorter chain. The purpose of this study is to synthesize DHDTP ligands and find out the optimum reaction conditions to produce DHDTP ligands with optimal purity using the BoxBehnken (BBD) response surface method (RSM). DHDTP ligands are synthesized from P2S5 by reflux after addition of n-hexanol under a nitrogen gas environment. Ammonium carbonate is added to the reflux to pH 7, then evaporated to remove the solvent. The synthesized DHDTP ligand was then purified by column chromatography with a mobile phase methanol : aquadest (2.5% gradient). DHDTP ligands were examined for purity using a reverse phase HPLC with a mobile phase methanol: aquadest 3: 2. The purity of the best DHDTP synthesis results obtained was 87.34%. The DHDTP ligand formed was characterized to confirm the structure of its ligand compound by using a UV spectrophotometer in which the synthesis product showed maximum absorption at a wavelength of 212 nm and mass spectroscopy ES- with m / z 297.1687.

scholarly journals APLIKASI RESPONSE SURFACE METHOD DALAM OPTIMASI PROSES THERMAL TREATMENT PASIR ZIRKON

2018 ◽  
Vol 4 (1) ◽  
pp. 1-5
Author(s):  
Zaldy Kurniawan ◽  
Muhammad Subhan ◽  
Ilham Ary Wahyudie
Keyword(s):  
Response Surface Methodology ◽  
Thermal Treatment ◽  
Saddle Point ◽  
Response Surface ◽  
Response Surface Method ◽  
Surface Method ◽  
Eigen Value

Abstrak   Zirconia (ZrO2) merupakan material keramik yang banyak digunakan di industri. Pasir zirkon (ZrSiO4) merupakan salah satu sumber zirkonia. Produksi zirkonia dari pasir zirkon dapat dilakukan dengan proses perlakuan panas atau perlakuan kimia dengan tujuan memecah ikatan antara ZrO2 dan SiO2. Pada penelitian ini Response Surface Methodology (RSM) diaplikasikan untuk menentukan nilai optimal persentase ZrO2 dari proses dekomposisi pasir zirkon melalui proses perlakuan panas. Sampel yang disiapkan sebanyak 13 variasi dengan 3 replikasi. Analisis hasil percobaan didapatkan Eigen value dengan nilai –0,146262 (X1) dan 0,172908 (X2). Hal ini menunjukkan bahwa kombinasi temperatur dan waktu penahanan tidak teridentifikasi optimum pada satu titik saja namun tersebar di seluruh daerah saddle point.

A Novel Environment Friendly Material: Sucrose Char Sulfonic Acid Catalyzed Three-Component Mannich Reaction

2014 ◽  
Vol 989-994 ◽  
pp. 134-137
Author(s):  
Yuan Yuan She ◽  
Xuan Yan Liu ◽  
Zhi Gao Yang
Keyword(s):  
Mannich Reaction ◽  
Carbonyl Compounds ◽  
Sulfonic Acid ◽  
Aromatic Aldehydes ◽  
Reaction Conditions ◽  
One Pot ◽  
Environment Friendly ◽  
Novel Environment ◽  
Acid Catalyzed ◽  
The One

Sucrose char sulfonic acid (SCSA) efficiently catalyzed the one-pot, three-component Mannich reaction of ketones, aromatic aldehydes and different amines in ethanol at 30°C and afforded the corresponding β-amino carbonyl compounds in good to excellent yields . This method provides a novel and improved modification of the three-component Mannich reaction in terms of mild reaction conditions , clean reaction profiles and a simple workup procedure.

scholarly journals Rapid and catalyst free synthesis of new bis(benzo[g]chromene) and bis(pyrano[3,2-c]chromene) derivatives and optimization of reaction conditions using response surface methodology

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39466-39474
Author(s):  
Fahimeh Sadat Hosseini ◽  
Mohammad Bayat ◽  
Milad Afsharnezhad
Keyword(s):  
Response Surface Methodology ◽  
Optical Properties ◽  
Liquid Crystals ◽  
Response Surface ◽  
Building Blocks ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis

One-pot synthesis of C2-symmetric chromene derivatives, which serve as building blocks to prepare liquid crystals with potential electrical or optical properties.

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