scholarly journals Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (46) ◽  
pp. 27021-27031 ◽  
Author(s):  
Geeta Sai Mani ◽  
Kavitha Donthiboina ◽  
Siddiq Pasha Shaik ◽  
Nagula Shankaraiah ◽  
Ahmed Kamal
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Synthetic Approach ◽  
One Pot ◽  
Metal Free ◽  
Novel Strategy

A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C–N and N–N bond formation has been demonstrated under transition metal-free and azide-free conditions.

Transition-Metal-Free Catalysis for the Reductive ­Functionalization of CO2 with Amines

Synlett ◽  
2018 ◽  
Vol 29 (05) ◽  
pp. 548-555 ◽  
Author(s):  
Liang-Nian He ◽  
Xiao-Fang Liu ◽  
Xiao-Ya Li ◽  
Chang Qiao
Keyword(s):  
Transition Metal ◽  
Energy Content ◽  
Bond Formation ◽  
Energy Storage Materials ◽  
One Pot ◽  
Metal Free ◽  
Recent Developments ◽  
Electron Reduction ◽  
Reduction Of Co2 ◽  
Hierarchical Reduction

Reductive functionalization of CO2 with amines and a reductant, which combines both reduction of CO2 and C–N bond formation in one pot to produce versatile chemicals and energy-storage materials such as formamides, aminals, and methylamines that are usually derived from petroleum feedstock, would be appealing and promising. Herein, we give a brief review on recent developments in the titled CO2 chemistry by employing transition-metal-free catalysis, which can be catalogued as below according to the diversified energy content of the products, that is formamides, aminals, and methylamines being consistent with 2-, 4-, and 6-electron reduction of CO2, respectively. Notably, hierarchical reduction of CO2 with amines to afford at least two products, for example, formamides and methylamines, could be realized with the same catalyst through tuning the hydrosilane type, reaction temperature, or CO2 pressure. Finally, the opportunities and challenges of the reductive functionalization of CO2 with amines are also highlighted.1 Introduction2 2-Electron Reduction of CO2 to Formamide3 6-Electron Reduction of CO2 to Methylamine4 4-Electron Reduction of CO2 to Aminal5 Hierarchical Reduction of CO2 with Amines6 Conclusion

Transition-metal-free oxidative carboazidation of acrylamides via cascade C–N and C–C bond-forming reactions

2014 ◽  
Vol 12 (25) ◽  
pp. 4329-4334 ◽  
Author(s):  
Jun Qiu ◽  
Ronghua Zhang
Keyword(s):  
Free Radical ◽  
Transition Metal ◽  
Efficient Method ◽  
Bond Formation ◽  
Cascade Process ◽  
Metal Free ◽  
Bond Forming ◽  
Bond Forming Reactions ◽  
Radical Cascade ◽  
Novel Strategy

A novel transition-metal-free oxidative carboazidation of acrylamides using inexpensive NaN3 and K2S2O8 was achieved, which not only provided an efficient method to prepare various N3-substituted oxindoles, but also represented a novel strategy for C–N and C–C bond formation via a free-radical cascade process.

A One-Pot, Transition-Metal-Free Procedure for C–O, C–S, and C–N Bond Formation at the Benzylic Position of Methylarenes

Synthesis ◽  
2015 ◽  
Vol 47 (09) ◽  
pp. 1280-1290 ◽  
Author(s):  
Hideo Togo ◽  
Hiroyuki Shimojo ◽  
Katsuhiko Moriyama
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
One Pot ◽  
Metal Free

A transition metal-free approach towards synthesis of β-carboline tethered 1,3,4-oxadiazoles via oxidative C–O bond formation

2019 ◽  
Vol 43 (1) ◽  
pp. 93-102 ◽  
Author(s):  
Dharmender Singh ◽  
Sandip Kumar Tiwari ◽  
Virender Singh
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

An efficient protocol has been developed for one-pot synthesis of biologically interesting β-carboline substituted 1,3,4-oxadiazoles via an I2-assisted oxidative C–O bond formation strategy.

scholarly journals Transition metal-free oxidative and deoxygenative C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with carboranyl lithium as an efficient synthetic approach to azaheterocyclic carboranes

2018 ◽  
Vol 14 ◽  
pp. 2618-2626 ◽  
Author(s):  
Lidia A Smyshliaeva ◽  
Mikhail V Varaksin ◽  
Pavel A Slepukhin ◽  
Oleg N Chupakhin ◽  
Valery N Charushin
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Advanced Materials ◽  
Synthetic Approach ◽  
Nucleophilic Substitution Of Hydrogen ◽  
One Pot ◽  
Metal Free

The direct C–H functionalization methodology has first been applied to perform transition metal-free C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with carboranyllithium. This atom- and step-economical approach, based on one-pot reactions of nucleophilic substitution of hydrogen (SN H) in non-aromatic azaheterocycles, affords novel imidazolyl-modified carboranes of two types (N-oxides and their deoxygenative analogues), which are particularly of interest in the design of advanced materials.

Metal free highly efficient C–N bond formation through 1,6-addition: synthesis and photophysical studies of diaryl methyl amino acid esters (DMAAEs)

2020 ◽  
Vol 44 (35) ◽  
pp. 14859-14864
Author(s):  
Deblina Roy ◽  
Abhineet Verma ◽  
Arpita Banerjee ◽  
Satyen Saha ◽  
Gautam Panda
Keyword(s):  
Amino Acid ◽  
Transition Metal ◽  
Bond Formation ◽  
Amino Acid Esters ◽  
Quinone Methides ◽  
One Pot ◽  
Metal Free ◽  
Photophysical Studies ◽  
The One ◽  
Acid Esters

A transition-metal free, proficient strategy for the one-pot synthesis of diverse diaryl methyl amino acid esters (DMAAEs) has been established from the easily accessible chiral amino acid esters and para-quinone methides (QMs) in very good to excellent yields.

Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

2017 ◽  
Vol 4 (11) ◽  
pp. 2119-2123 ◽  
Author(s):  
Yuan Liu ◽  
Yang Yu ◽  
Yiwei Fu ◽  
Yonghai Liu ◽  
Lei Shi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Synthetic Approach ◽  
One Pot ◽  
Metal Free

A transition-metal-free “one-pot” synthetic approach for the synthesis of indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed.

Transition-metal-free halocarbocyclisation of acrylamides using K2S2O8

2017 ◽  
Vol 41 (6) ◽  
pp. 352-357 ◽  
Author(s):  
Haiwei Ye ◽  
Liping Zhou ◽  
Yunhua Chen ◽  
Jun Qiu
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Direct Transition ◽  
Metal Free ◽  
Novel Strategy

A novel and direct transition-metal-free oxidative halocarbocyclisation of acrylamides using inexpensive KX (X = I, Br, Cl) and K2S2O8 has been developed. This methodology not only provides an efficient way to construct valuable halogenated oxindoles in good to excellent yields, but also represents a novel strategy for C–X and C–C bond formation.

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