Transition-metal-free synthesis of indolizines via [3 + 2]-annulation from α-bromoenals and 2-substituted azaarenes

2017 ◽  
Vol 4 (11) ◽  
pp. 2119-2123 ◽  
Author(s):  
Yuan Liu ◽  
Yang Yu ◽  
Yiwei Fu ◽  
Yonghai Liu ◽  
Lei Shi ◽  
...  
Keyword(s):  
Transition Metal ◽  
Synthetic Approach ◽  
One Pot ◽  
Metal Free

A transition-metal-free “one-pot” synthetic approach for the synthesis of indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed.

scholarly journals Iodine-mediated C–N and N–N bond formation: a facile one-pot synthetic approach to 1,2,3-triazoles under metal-free and azide-free conditions

RSC Advances ◽  
2019 ◽  
Vol 9 (46) ◽  
pp. 27021-27031 ◽  
Author(s):  
Geeta Sai Mani ◽  
Kavitha Donthiboina ◽  
Siddiq Pasha Shaik ◽  
Nagula Shankaraiah ◽  
Ahmed Kamal
Keyword(s):  
Transition Metal ◽  
Bond Formation ◽  
Synthetic Approach ◽  
One Pot ◽  
Metal Free ◽  
Novel Strategy

A novel strategy towards the synthesis of 1,4-disubstituted 1,2,3-triazoles via C–N and N–N bond formation has been demonstrated under transition metal-free and azide-free conditions.

scholarly journals Transition metal-free oxidative and deoxygenative C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with carboranyl lithium as an efficient synthetic approach to azaheterocyclic carboranes

2018 ◽  
Vol 14 ◽  
pp. 2618-2626 ◽  
Author(s):  
Lidia A Smyshliaeva ◽  
Mikhail V Varaksin ◽  
Pavel A Slepukhin ◽  
Oleg N Chupakhin ◽  
Valery N Charushin
Keyword(s):  
Transition Metal ◽  
Nucleophilic Substitution ◽  
Advanced Materials ◽  
Synthetic Approach ◽  
Nucleophilic Substitution Of Hydrogen ◽  
One Pot ◽  
Metal Free

The direct C–H functionalization methodology has first been applied to perform transition metal-free C–H/C–Li cross-couplings of 2H-imidazole 1-oxides with carboranyllithium. This atom- and step-economical approach, based on one-pot reactions of nucleophilic substitution of hydrogen (SN H) in non-aromatic azaheterocycles, affords novel imidazolyl-modified carboranes of two types (N-oxides and their deoxygenative analogues), which are particularly of interest in the design of advanced materials.

scholarly journals An entry to 2-(cyclobut-1-en-1-yl)-1H-indoles through a cyclobutenylation/deprotection cascade

2021 ◽  
Author(s):  
Philipp Natho ◽  
Zeyu Yang ◽  
Lewis Allen ◽  
Juliette Rey ◽  
Andrew J P White ◽  
...  
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
Mild Conditions

A transition-metal-free strategy for the synthesis of 2-(cyclobut-1-en-1-yl)-1H-indoles under mild conditions is described herein. A series of substituted 2-(cyclobut-1-en-1-yl)-1H-indoles are accessed by a one-pot cyclobutenylation/deprotection cascade from N-Boc protected indoles....

ChemInform Abstract: Transition Metal Free Intramolecular S-Arylation: One-Pot Synthesis of Thiochromen-4-ones.

ChemInform ◽  
2014 ◽  
Vol 45 (13) ◽  
pp. no-no
Author(s):  
T. A. Jenifer Vijay ◽  
Kebbahalli N. Nandeesh ◽  
Goravanahalli M. Raghavendra ◽  
Kanchugarakoppal S. Rangappa ◽  
Kempegowda Mantelingu
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

ChemInform Abstract: A One-Pot Transition Metal Free Tandem Process to 1,4-Benzodiazepine Scaffolds.

ChemInform ◽  
2013 ◽  
Vol 44 (17) ◽  
pp. no-no
Author(s):  
Yanqiu Li ◽  
Chunjing Zhan ◽  
Bingchuan Yang ◽  
Xiaoqun Cao ◽  
Chen Ma
Keyword(s):  
Transition Metal ◽  
One Pot ◽  
Metal Free ◽  
Tandem Process

One-pot synthesis of thioesters with sodium thiosulfate as a sulfur surrogate under transition metal-free conditions

2018 ◽  
Vol 16 (11) ◽  
pp. 1871-1881 ◽  
Author(s):  
Yen-Sen Liao ◽  
Chien-Fu Liang
Keyword(s):  
Transition Metal ◽  
Sodium Thiosulfate ◽  
Sulfur Source ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

We have developed a one-pot reaction to provide thioester derivativesviasodium thiosulfate as a sulfur source under transition metal-free conditions.

One-pot transition-metal free transamidation to sterically hindered amides

2018 ◽  
Vol 5 (20) ◽  
pp. 2950-2954 ◽  
Author(s):  
Weijie Guo ◽  
Jingjun Huang ◽  
Hongxiang Wu ◽  
Tingting Liu ◽  
Zhongfeng Luo ◽  
...  
Keyword(s):  
Transition Metal ◽  
Good Yield ◽  
One Pot ◽  
Metal Free ◽  
Highly Efficient ◽  
Sterically Hindered

A highly efficient one-pot transamidation of primary amides has been developed under transition-metal free conditions, generating a variety of amides including hindered amides in good yield (up to 86%) catalyzed by CsF.

scholarly journals SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)

RSC Advances ◽  
2020 ◽  
Vol 10 (29) ◽  
pp. 17288-17292 ◽  
Author(s):  
Yiyong Zhao ◽  
Junjie Wei ◽  
Shuting Ge ◽  
Guofu Zhang ◽  
Chengrong Ding
Keyword(s):  
Transition Metal ◽  
Nitrogen Source ◽  
Functional Group ◽  
Cascade Process ◽  
One Pot ◽  
Metal Free ◽  
Work Up

Our gram-scale process uses abundant and inexpensive aldehydes, a clean nitrogen source, requires no additional carbon atoms, is transition-metal free, and features easy work-up and excellent functional group compatibility.

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