scholarly journals Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

RSC Advances ◽  
2019 ◽  
Vol 9 (51) ◽  
pp. 29936-29941 ◽  
Author(s):  
Ge Wang ◽  
Jing Liu ◽  
Lin Zhu ◽  
Yuming Guo ◽  
Lin Yang
Keyword(s):  
Photodynamic Therapy ◽  
Energy Metabolism ◽  
Silver Sulfide ◽  
Light Irradiation ◽  
Hybrid Nanoparticles ◽  
Reactive Oxidative Species ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Silver Sulfide Nanoparticles ◽  
Oxidative Species

Ag2S/BSA hybrid nanoparticles were prepared and studied for their ability to inhibit the growth of human lymphoma cells under light irradiation, via inducing the accumulation of intracellular reactive oxidative species to disrupt energy metabolism.

Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells

APOPTOSIS ◽  
2006 ◽  
Vol 11 (11) ◽  
pp. 2031-2042 ◽  
Author(s):  
Ingegerd Eggen Furre ◽  
Michael T. N. Møller ◽  
Susan Shahzidi ◽  
Jahn M. Nesland ◽  
Qian Peng
Keyword(s):  
Photodynamic Therapy ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Apoptotic Induction

scholarly journals Photosensitizers Based on G-Quadruplex Ligand for Cancer Photodynamic Therapy

Genes ◽  
2020 ◽  
Vol 11 (11) ◽  
pp. 1340
Author(s):  
Keiko Kawauchi ◽  
Ryoto Urano ◽  
Natsuki Kinoshita ◽  
Shin Kuwamoto ◽  
Takeru Torii ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Secondary Structure ◽  
Molecular Target ◽  
Untranslated Regions ◽  
Reactive Oxidative Species ◽  
Dna And Rna ◽  
Porphyrin Derivatives ◽  
G Quadruplex ◽  
Novel Strategy ◽  
Oxidative Species

G-quadruplex (G4) is the non-canonical secondary structure of DNA and RNA formed by guanine-rich sequences. G4-forming sequences are abundantly located in telomeric regions and in the promoter and untranslated regions (UTR) of cancer-related genes, such as RAS and MYC. Extensive research has suggested that G4 is a potential molecular target for cancer therapy. Here, we reviewed G4 ligands as photosensitizers for cancer photodynamic therapy (PDT), which is a minimally invasive therapeutic approach. The photosensitizers, such as porphyrins, were found to be highly toxic against cancer cells via the generation of reactive oxidative species (ROS) upon photo-irradiation. Several porphyrin derivatives and analogs, such as phthalocyanines, which can generate ROS upon photo-irradiation, have been reported to act as G4 ligands. Therefore, they have been implicated as promising photosensitizers that can selectively break down cancer-related DNA and RNA forming G4. In this review, we majorly focused on the potential application of G4 ligands as photosensitizers, which would provide a novel strategy for PDT, especially molecularly targeted PDT (mtPDT).

Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells

2011 ◽  
Vol 10 (11) ◽  
pp. 1773 ◽  
Author(s):  
Susan Shahzidi ◽  
Beata Čunderlíková ◽  
Antoni Więdłocha ◽  
Yan Zhen ◽  
Vlada Vasovič ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Photodynamic Therapy ◽  
Lymphoma Cells ◽  
Human Lymphoma

Green synthesis, characterization of silver sulfide nanoparticles and antibacterial activity evaluation

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Antibacterial Activity ◽  
Large Scale ◽  
Research Work ◽  
Silver Sulfide ◽  
Morphological Properties ◽  
Effective Diameter ◽  
Novel Approach ◽  
Transmission Electron ◽  
Green Route ◽  
Silver Sulfide Nanoparticles

This research work presents a facile and green route for synthesis silver sulfide (Ag2SNPs) nanoparticles from silver nitrate (AgNO3) and sodium sulfide nonahydrate (Na2S.9H2O) in the presence of rosemary leaves aqueous extract at ambient temperature (27 oC). Structural and morphological properties of Ag2SNPs nanoparticles were analyzed by X-ray diffraction (XRD) and transmission electron microscopy (TEM). The surface Plasmon resonance for Ag2SNPs was obtained around 355 nm. Ag2SNPs was spherical in shape with an effective diameter size of 14 nm. Our novel approach represents a promising and effective method to large scale synthesis of eco-friendly antibacterial activity silver sulfide nanoparticles.

A ROLE OF PROTEINS OF THE OUTER MEMBRANE OF Shewanella oneidensis MR-1 BACTERIA IN FORMATION AND STABILIZATION OF SILVER SULFIDE NANOPARTICLES

2015 ◽  
pp. 41-48 ◽  
Author(s):  
T. A. Voeikova ◽  
A. S. Shebanova ◽  
Yu. D. Ivanov ◽  
A. L. Kaysheva ◽  
L. M. Novikova ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Shewanella Oneidensis ◽  
Silver Sulfide ◽  
Silver Sulfide Nanoparticles

scholarly journals Direct TEM observation of the “acanthite α-Ag2S–argentite β-Ag2S” phase transition in a silver sulfide nanoparticle

2019 ◽  
Vol 1 (4) ◽  
pp. 1581-1588 ◽  
Author(s):  
S. I. Sadovnikov ◽  
E. Yu. Gerasimov
Keyword(s):  
Electron Microscopy ◽  
Phase Transition ◽  
Transmission Electron Microscopy ◽  
Silver Sulfide ◽  
Transmission Electron ◽  
Silver Sulfide Nanoparticles ◽  
Microscopy Method ◽  
Electron Microscopy Method ◽  
First Time

For the first time, the α-Ag2S (acanthite)–β-Ag2S (argentite) phase transition in a single silver sulfide nanoparticles has been observed in situ using a high-resolution transmission electron microscopy method in real time.

The effects of photodynamic therapy with Photodithazine on HPV 16 E6/E7 associated cervical cancer model

2011 ◽  
Vol 15 (03) ◽  
pp. 174-180 ◽  
Author(s):  
Lan Ying Wen ◽  
Su-Mi Bae ◽  
Jin Hwan Do ◽  
Kye-Shin Park ◽  
Woong Shick Ahn
Keyword(s):  
Cervical Cancer ◽  
Photodynamic Therapy ◽  
Growth Inhibition ◽  
Biological Significance ◽  
Light Irradiation ◽  
Tumor Growth Inhibition ◽  
Cancer Model ◽  
Hpv 16

Photodynamic therapy (PDT) is a promising treatment for cancer that has been recently accepted in the clinic. In this study, we examined a biological significance of PDT with a chlorin-based photosensitizer, Photodithazine, on cervical cancer model. When human papillomavirus type 16 (HPV16)- transformed mouse TC-1 cells were exposed to varied doses of Photodithazine with light irradiation (6.25 J/cm2), the significant growth inhibition of TC-1 cells was observed at 0.75 μg/mL of Photodithazine. The damaged cells by Photodithazine/PDT were categorized to be early and late apoptosis, as determined by annexin V staining. Photodithazine was primarily localized at lysosome apparatus within TC-1 cells while it was rapidly accumulated and sustained for initial 3 h in tumor tissue of TC-1 tumor bearing mice after IV injection. The tumor growth inhibition by Photodithazine/PDT with light irradiation (300 J/cm2) was examined after injection of various concentration of Photodithazine in tumor mice system. Our results show that Photodithazine/PDT might have significant advantages in the selective killing of tumor lesions in HPV 16 E6/E7 associated cervical cancer model, both in vitro and in vivo.

Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells

2009 ◽  
Vol 28 (6) ◽  
pp. 545-551 ◽  
Author(s):  
Young-Ok Son ◽  
Yong-Suk Jang ◽  
Xianglin Shi ◽  
Jeong-Chae Lee
Keyword(s):  
Cell Death ◽  
Glucose Oxidase ◽  
Lymphoma Cells ◽  
Human Lymphoma
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