Simultaneously targeting mitochondria and endoplasmic reticulum by photodynamic therapy induces apoptosis in human lymphoma cells

2011 ◽  
Vol 10 (11) ◽  
pp. 1773 ◽  
Author(s):  
Susan Shahzidi ◽  
Beata Čunderlíková ◽  
Antoni Więdłocha ◽  
Yan Zhen ◽  
Vlada Vasovič ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Photodynamic Therapy ◽  
Lymphoma Cells ◽  
Human Lymphoma

Involvement of both caspase-dependent and -independent pathways in apoptotic induction by hexaminolevulinate-mediated photodynamic therapy in human lymphoma cells

APOPTOSIS ◽  
2006 ◽  
Vol 11 (11) ◽  
pp. 2031-2042 ◽  
Author(s):  
Ingegerd Eggen Furre ◽  
Michael T. N. Møller ◽  
Susan Shahzidi ◽  
Jahn M. Nesland ◽  
Qian Peng
Keyword(s):  
Photodynamic Therapy ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Apoptotic Induction

scholarly journals Silver sulfide nanoparticles for photodynamic therapy of human lymphoma cells via disruption of energy metabolism

RSC Advances ◽  
2019 ◽  
Vol 9 (51) ◽  
pp. 29936-29941 ◽  
Author(s):  
Ge Wang ◽  
Jing Liu ◽  
Lin Zhu ◽  
Yuming Guo ◽  
Lin Yang
Keyword(s):  
Photodynamic Therapy ◽  
Energy Metabolism ◽  
Silver Sulfide ◽  
Light Irradiation ◽  
Hybrid Nanoparticles ◽  
Reactive Oxidative Species ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Silver Sulfide Nanoparticles ◽  
Oxidative Species

Ag2S/BSA hybrid nanoparticles were prepared and studied for their ability to inhibit the growth of human lymphoma cells under light irradiation, via inducing the accumulation of intracellular reactive oxidative species to disrupt energy metabolism.

Activation of JNK and c-Jun is involved in glucose oxidase-mediated cell death of human lymphoma cells

2009 ◽  
Vol 28 (6) ◽  
pp. 545-551 ◽  
Author(s):  
Young-Ok Son ◽  
Yong-Suk Jang ◽  
Xianglin Shi ◽  
Jeong-Chae Lee
Keyword(s):  
Cell Death ◽  
Glucose Oxidase ◽  
Lymphoma Cells ◽  
Human Lymphoma

Endoplasmic Reticulum-Localized Two-Photon-Absorbing Boron Dipyrromethenes as Advanced Photosensitizers for Photodynamic Therapy

2018 ◽  
Vol 61 (9) ◽  
pp. 3952-3961 ◽  
Author(s):  
Yimin Zhou ◽  
Ying-Kit Cheung ◽  
Chao Ma ◽  
Shirui Zhao ◽  
Di Gao ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Photodynamic Therapy ◽  
Two Photon

scholarly journals Adhesion to high endothelial venules: a model for dissemination mechanisms in non-Hodgkin's lymphoma

Blood ◽  
1993 ◽  
Vol 82 (1) ◽  
pp. 262-267 ◽  
Author(s):  
R Stauder ◽  
S Hamader ◽  
B Fasching ◽  
G Kemmler ◽  
J Thaler ◽  
...  
Keyword(s):  
Hodgkin’S Lymphoma ◽  
Lymphocytic Leukemia ◽  
Hodgkin's Lymphoma ◽  
Lymphoma Cells ◽  
High Endothelial Venules ◽  
Non Hodgkin’S Lymphoma ◽  
Non Hodgkin's Lymphoma ◽  
Human Lymphoma ◽  
Binet Stage

The interaction of human lymphoma cells with high endothelial venules (HEVs) on sections of lymphatic tissues was studied in 44 cases of non- Hodgkin's lymphoma (NHL) with the in vitro HEV binding assay. The relative adherence ratio (RAR) of lymphoma cells to HEVs as related to that of reactive lymphocytes was 0.29 to 4.64 in 38 cases of B chronic lymphocytic leukemia (CLL), 1.15 and 1.54 in two cases of immunocytic NHL, 1.12 and 0.70 in two cases of centrocytic NHL, 1.98 in one case of a peripheral T-NHL, whereas plasma cell leukemia cells adhered very weakly (RAR 0.1). Among the patients suffering from CLL a pronounced HEV binding ability of tumor cells correlated significantly with the more unfavorable Binet stages B and C (median 1.32) as well as with a widespread lymphatic dissemination, which strongly indicates a hematogenous, HEV-mediated spread (median 1.34). In contrast, weak adherence to HEVs was associated with Binet stage A (median 0.85; P < .05) and with a lacking or only localized clinical involvement of lymph nodes (median 0.84; P < .01). Thus, specific HEV recognition processes even operate in lymphoid neoplasms and via this mechanism seem to influence the dissemination of tumors.

scholarly journals Label-free impedance flow cytometry for nanotoxicity screening

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Melanie Ostermann ◽  
Alexander Sauter ◽  
Ying Xue ◽  
Eivind Birkeland ◽  
Julia Schoelermann ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Human Health ◽  
Trypan Blue ◽  
Label Free ◽  
Trigger Level ◽  
Lymphoma Cells ◽  
Human Lymphoma ◽  
Buffer Composition ◽  
Cost Efficient

AbstractThe development of reliable and cost-efficient methods to assess the toxicity of nanomaterials (NMs) is critical for the proper identification of their impact on human health and for ensuring a safe progress of nanotechnology. In this study, we investigated the reliability and applicability of label-free impedance flow cytometry (IFC) for in vitro nanotoxicity screening, which avoids time-consuming labelling steps and minimizes possible NM-induced interferences. U937 human lymphoma cells were exposed for 24 h to eight different nanomaterials at five concentrations (2, 10, 20, 50, and 100 μg/mL). The NMs’ effect on viability was measured using IFC and the results were compared to those obtained by trypan blue (TB) dye exclusion and conventional flow cytometry (FC). To discriminate viable from necrotic cells, the IFC measurement settings regarding signal trigger level and frequency, as well as the buffer composition, were optimised. A clear discrimination between viable and necrotic cells was obtained at 6 MHz in a sucrose-based measurement buffer. Nanomaterial-induced interferences were not detected for IFC. The IFC and TB assay results were in accordance for all NMs. The IFC was found to be robust, reliable and less prone to interferences due to the advantage of being label-free.

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