scholarly journals Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 1132-1141
Author(s):  
Yunxiang Qi ◽  
Jinyi Lang ◽  
Xiaodong Zhu ◽  
Jianming Huang ◽  
Lu Li ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Prognostic Factor ◽  
Cancer Cells ◽  
Squamous Carcinoma ◽  
Independent Prognostic Factor ◽  
Down Regulation ◽  
Cervical Cancer Cells ◽  
Radiation Induced

The phosphorylation of EGFRThr654 is required for nuclear EGFR importing, and our previous study has shown that pEGFRThr654 is an independent prognostic factor for the low survival rate of patients with cervical squamous carcinoma.

scholarly journals Retraction: Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells

RSC Advances ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 5021-5021
Author(s):  
Laura Fisher
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Down Regulation ◽  
Cervical Cancer Cells ◽  
Radiation Induced

Retraction of ‘Down-regulation of the radiation-induced pEGFRThr654 mediated activation of DNA-PK by Cetuximab in cervical cancer cells’ by Yunxiang Qi et al., RSC Adv., 2020, 10, 1132–1141, DOI: 10.1039/C9RA04962B.

Down-regulation of phospho-non-receptor Src tyrosine kinases contributes to growth inhibition of cervical cancer cells

2010 ◽  
Vol 28 (4) ◽  
pp. 1495-1506 ◽  
Author(s):  
Lu Kong ◽  
Zhihong Deng ◽  
Yanzhong Zhao ◽  
Yamei Wang ◽  
Fazlul H. Sarkar ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Growth Inhibition ◽  
Cancer Cells ◽  
Tyrosine Kinases ◽  
Down Regulation ◽  
Src Tyrosine Kinases ◽  
Cervical Cancer Cells

scholarly journals Silencing PROK2 Inhibits Invasion of Human Cervical Cancer Cells by Targeting MMP15 Expression

2020 ◽  
Vol 21 (17) ◽  
pp. 6391
Author(s):  
Min-Hua Wu ◽  
Pei-Ru Wu ◽  
Yi-Hsien Hsieh ◽  
Chia-Liang Lin ◽  
Chung-Jung Liu ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Overall Survival Rate ◽  
Potential Biomarker ◽  
Cervical Cancer Cells ◽  
Human Cervical Cancer Cells ◽  
Human Cervical Cancer

Cervical cancer is the second most frequent type of gynecologic cancer worldwide. Prokineticin 2 (PROK2) is reported to be involved in tumor progression in some malignant tumors. However, the role of PROK2 in the development of cervical cancer remains unknown. Our results indicate that PROK2 is overexpressed in the human cervical cancer. Cervical cancer patients with high PROK2 expression have a shorter overall survival rate (OS) and disease-free survival rate (DFS). PROK2 acts as a potential biomarker for predicting OS and DFS of cervical cancer patients. We further show that PROK2 is important factor for oncogenic migration and invasion in human cervical cancer cells. Knockdown PROK2 significantly inhibited cell migration, invasion, and MMP15 protein expression in HeLa cells. High expression of MMP15 is confirmed in the human cervical cancer, is significantly associated with the shorter overall survival rate (OS) and is correlated with PROK2 expression. Overexpression of PROK2 using PROK2 plasmid significantly reverses the function of knockdown PROK2, and further upregulates MMP15 expression, migration and invasion of human cervical cancer cells. In conclusion, our findings are the first to demonstrate the role of PROK2 as a novel and potential biomarker for clinical use, and reveal the oncogenic functions of PROK2 as therapeutic target for cervical cancer.

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