Down-regulation of long non-coding RNA ANRIL inhibits the proliferation, migration and invasion of cervical cancer cells

2018 ◽  
Vol 23 (2) ◽  
pp. 243-253 ◽  
Author(s):  
Wei-Yi Zhang ◽  
Yin-Jiao Liu ◽  
Yan He ◽  
Ping Chen
Keyword(s):  
Cervical Cancer ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Down Regulation ◽  
Non Coding Rna ◽  
Cervical Cancer Cells ◽  
Long Non Coding Rna

scholarly journals The significance of homeodomain transcription factor 2 in colon cancer cells

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Yang He ◽  
Peng Gong ◽  
Sitong Wang ◽  
Qing Xu ◽  
Jianhua Chen
Keyword(s):  
Cervical Cancer ◽  
Colon Cancer ◽  
Transcription Factor ◽  
Cancer Cells ◽  
Migration And Invasion ◽  
Colon Cancer Cells ◽  
Homeodomain Transcription Factor ◽  
Non Coding Rna ◽  
Related Proteins ◽  
Long Non Coding Rna

Abstract Background Colon cancer is a serious malignant tumor. It has been reported that paired-like homeodomain transcription factor 2 (PITX2) can promote the progression of several types of cancer via regulating the Wnt/β-catenin pathway. It has also been demonstrated that high levels of long non-coding RNA (lncRNA) gastric carcinoma high expressed transcript 1 (GHET1) can also promote the development of cervical cancer via activating the Wnt/β-catenin pathway. However, whether PITX2 can affect the development of colon cancer via regulating the expression of lncRNA GHET1 remains unclear. Results The results demonstrated that PITX2 knockdown attenuated the proliferation, migration and invasion abilities of colon cancer cells. Additionally, PITX2 promoted the expression of lncRNA GHET1 via binding to its promoter. Overexpression of lncRNA GHET1 induced the expression of Wnt/β-catenin signaling-related proteins, cyclin D1, c-Myc and MMP-7. Furthermore, lncRNA GHET1 overexpression abrogated the PITX2 silencing-mediated decreased proliferation, migration and invasion abilities of colon cancer cells. Conclusion The findings of the present study suggested that PITX2 could enhance the proliferation, migration and invasion abilities of colon cancer cells via upregulating lncRNA GHET1 and activating the Wnt/β-catenin pathway.

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