scholarly journals Riboflavin-protected ultrasmall silver nanoclusters with enhanced antibacterial activity and the mechanisms

RSC Advances ◽  
2019 ◽  
Vol 9 (23) ◽  
pp. 13275-13282 ◽  
Author(s):  
Xizhe Li ◽  
Tao Fu ◽  
Bingyu Li ◽  
Peng Yan ◽  
Yayan Wu
Keyword(s):  
Antibacterial Activity ◽  
Surface Coating ◽  
Silver Nanoclusters ◽  
Highly Efficient ◽  
Good Biocompatibility

Riboflavin acted as a surface coating to synthesize ultrasmall silver nanoclusters and RF@AgNCs possessed highly efficient antibacterial activity and good biocompatibility.

Ultrasmall silver nanoclusters: Highly efficient antibacterial activity and their mechanisms

2017 ◽  
Vol 5 (2) ◽  
pp. 247-257 ◽  
Author(s):  
Jian-Cheng Jin ◽  
Xiao-Juan Wu ◽  
Juan Xu ◽  
Bei-Bei Wang ◽  
Feng-Lei Jiang ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Antibacterial Activities ◽  
Silver Nanoclusters ◽  
E Coli ◽  
Highly Efficient

We study the antibacterial activities of bifunctional fluorescent DHLA-AgNCs against three types of bacteria, and the antibacterial mechanisms against differentE. colistrains are different.

scholarly journals Antibacterial activity of graphene oxide nanosheet against multidrug resistant superbugs isolated from infected patients

2020 ◽  
Vol 7 (7) ◽  
pp. 200640 ◽  
Author(s):  
Md. Toasin Hossain Aunkor ◽  
Topu Raihan ◽  
Shamsul H. Prodhan ◽  
H. S. C. Metselaar ◽  
Syeda Umme Fahmida Malik ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Graphene Oxide ◽  
Antimicrobial Property ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Drug Resistant ◽  
Graphene Nanosheet ◽  
Solid Agar ◽  
Good Biocompatibility ◽  
Agar Well Diffusion Method

Graphene oxide (GO) is a derivative of graphene nanosheet which is the most promising material of the decade in biomedical research. In particular, it has been known as an antimicrobial nanomaterial with good biocompatibility. In this study, we have synthesized and characterize GO and checked its antimicrobial property against different Gram-negative and Gram-positive multidrug drug resistant (MDR) hospital superbugs grown in solid agar-based nutrient plates with and without human serum through the utilization of agar well diffusion method, live/dead fluorescent staining and genotoxicity analysis. No significant changes in antibacterial activity were found in these two different conditions. We also compare the bactericidal capability of GO with some commonly administered antibiotics and in all cases the degree of inhibition is found to be higher. The data presented here are novel and show that GO is an effective bactericidal agent against different superbugs and can be used as a future antibacterial agent.

Highly efficient g-C3N4/Cr-ZnO nanocomposites with superior photocatalytic and antibacterial activity

2020 ◽  
Vol 401 ◽  
pp. 112776 ◽  
Author(s):  
Muhammad Azam Qamar ◽  
Sammia Shahid ◽  
Mohsin Javed ◽  
Shahid Iqbal ◽  
Mudassar Sher ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Highly Efficient

Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence

2016 ◽  
Vol 8 (16) ◽  
pp. 10147-10154 ◽  
Author(s):  
Siamak Javani ◽  
Romina Lorca ◽  
Alfonso Latorre ◽  
Cristina Flors ◽  
Aitziber L. Cortajarena ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Silver Nanoclusters ◽  
Oligonucleotide Sequence

scholarly journals Preparation And Characterization of Sodium Alginate/Acrylic Acid Composite Hydrogels Conjugated To Silver Nanoparticles As An Antibiotic Delivery System

2021 ◽  
Author(s):  
Parvaneh Mohamadinia ◽  
Navideh Anarjan
Keyword(s):  
Silver Nanoparticles ◽  
Antibacterial Activity ◽  
Acrylic Acid ◽  
Sodium Alginate ◽  
Release Kinetics ◽  
Silver Ions ◽  
Composite Hydrogels ◽  
Gel Fraction ◽  
Good Biocompatibility ◽  
The Impact

Abstract Hydrogels are specific groups of polymers that are highly swellable in aqueous solutions, despite their water-in-soluble structures. Thus, they are promising drug delivery systems attributable to their unique characteristics such as high hydrophilicity, high controllability, facile production routines and, good biocompatibility. The aim of this research was the preparation of sodium alginate/acrylic acid composite hydrogels conjugated to silver nanoparticles to deliver the cephalexin as a model antibiotic compound. The reduction of silver ions into silver nanoparticles as well as the stabilization of created nanoparticles ensued simultaneously with hydrogel backbone formulation during microwave irradiation and monomer cross-linking processes. The impact of acrylic acid and silver ions concentrations and also the radiation time of microwave were then investigated on the main characteristics of hydrogels, namely, swelling ratio, gel fraction, cephalexin load and, antibacterial activity. The results indicated that the hydrogels’ characteristics could be significantly predicted by studied all independent parameters, through various second-order polynomial models. The multiple optimization analysis suggested that the prepared hydrogels using 7.8 g acrylic acid and 1.5 g silver nitrate and 1 min microwave radiation could give the best hydrogels with the highest swelling degree, gel fraction, cephalexin absorption and, antibacterial activity. The morphology and either absorption or release kinetics of cephalexin by/from the optimum prepared hydrogels were also investigated. No significant differences between the experimental and predicted data was confirmed the suitability of the suggested models.

scholarly journals Highly efficient microwave synthesis of rhodanine and 2-thiohydantoin derivatives and determination of relationships between their chemical structures and antibacterial activity

RSC Advances ◽  
2019 ◽  
Vol 9 (67) ◽  
pp. 39367-39380 ◽  
Author(s):  
Waldemar Tejchman ◽  
Bartosz Orwat ◽  
Izabela Korona-Głowniak ◽  
Anna Barbasz ◽  
Ireneusz Kownacki ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Microwave Synthesis ◽  
Chemical Structure ◽  
Biological Properties ◽  
Microwave Assisted Synthesis ◽  
Chemical Structures ◽  
Microwave Assisted ◽  
Highly Efficient

An efficient microwave-assisted synthesis of rhodanine and 2-thiohydantoin derivatives, and the correlation between their chemical structure and biological properties is reported.

Induction of Bone Remodeling by Raloxifene-Doped Iron Oxide Functionalized with Hydroxyapatite to Accelerate Fracture Healing

2021 ◽  
Vol 17 (5) ◽  
pp. 932-941
Author(s):  
Gengqi Wang ◽  
Wenqiang Xu ◽  
Junjie Zhang ◽  
Tian Tang ◽  
Jing Chen ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Iron Oxide ◽  
Bone Fractures ◽  
Rt Pcr ◽  
Target Drug Delivery ◽  
Target Drug ◽  
Proliferation And Differentiation ◽  
Physicochemical Features ◽  
Good Biocompatibility ◽  
Co Precipitation

Repairing fractures in the presence of infection is a major challenge that is currently declining using nanotechnology. By producing iron oxide nanoparticles (NPs) containing hydroxyapatite and Raloxifene (R-IONPs-HA), this study tries to target drug delivery, control infection and promotion of the cells proliferation/differentiation to repair damaged tissue. After the production of R-IONPs-HA through co-precipitation, the physicochemical features of the NPs were considered by SEM, TEM, DLS and XRD methods, and the possibility of drug release. The effect of R-IONPs-HA on MC3T3-E1 cell proliferation/differentiation was determined by CCK-assay and microscopic observations. Also, Gram-negative and -positive bacteria were applied to evaluate the antibacterial activity. Finally, cell differentiation biomarkers like an ALP, OCN, and RUNX-2 genes were examined by real time (RT)-PCR. The results showed that R-IONPs-HA was spherical with dimensions of 98.1 ± 1.17 nm. In addition, the results of Zeta and XRD confirmed the loading HA and R on IONPs. Also, the release rate of R and HA in 64 h with pH 6 reached 61.4 and 30.4%, respectively. The anti-bacterial activity of R-IONPs-HA on Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa bacteria showed a significant reduction in infection. Also, MC3T3-E1 cells showed greater proliferation and differentiation by R-IONPs-HA compared to other groups. Increased expression of ossification genes such as OCN, and RUNX-2 confirmed this claim. Finally, R-IONPs-HA with good biocompatibility, antibacterial activity and ossification induction has great potential to repair bone fractures and prevent infection.

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