Consequences of isolated critical monomer sequence errors for the hydrolysis behaviors of sequenced degradable polyesters

2019 ◽  
Vol 10 (36) ◽  
pp. 4930-4934
Author(s):  
Jamie A. Nowalk ◽  
Jordan H. Swisher ◽  
Tara Y. Meyer

Despite the known sensitivity to sequence mutations of biological polymers, little is known about the effects of errors in sequenced synthetic copolymers.

2004 ◽  
Vol 40 (1) ◽  
pp. 5-25 ◽  
Author(s):  
David Cunliffe ◽  
Sivanand Pennadam ◽  
Cameron Alexander
Keyword(s):  

2013 ◽  
Vol 30 (9) ◽  
pp. 2209-2223 ◽  
Author(s):  
Iona M. MacLeod ◽  
Denis M. Larkin ◽  
Harris A. Lewin ◽  
Ben J. Hayes ◽  
Mike E. Goddard

2000 ◽  
Vol 33 (2) ◽  
pp. 647-647
Author(s):  
Chritopher Y. Li ◽  
Donghang Yan ◽  
Stephen Z. D. Cheng ◽  
Feng Bai ◽  
Tianbai He ◽  
...  

2019 ◽  
Vol 5 (4) ◽  
pp. 709-718 ◽  
Author(s):  
Tyler K. Lytle ◽  
Li-Wei Chang ◽  
Natalia Markiewicz ◽  
Sarah L. Perry ◽  
Charles E. Sing

2021 ◽  
Vol 118 (23) ◽  
pp. e2102168118
Author(s):  
Kelvin Anggara ◽  
Yuntao Zhu ◽  
Giulio Fittolani ◽  
Yang Yu ◽  
Theodore Tyrikos-Ergas ◽  
...  

Correlating the structures and properties of a polymer to its monomer sequence is key to understanding how its higher hierarchy structures are formed and how its macroscopic material properties emerge. Carbohydrate polymers, such as cellulose and chitin, are the most abundant materials found in nature whose structures and properties have been characterized only at the submicrometer level. Here, by imaging single-cellulose chains at the nanoscale, we determine the structure and local flexibility of cellulose as a function of its sequence (primary structure) and conformation (secondary structure). Changing the primary structure by chemical substitutions and geometrical variations in the secondary structure allow the chain flexibility to be engineered at the single-linkage level. Tuning local flexibility opens opportunities for the bottom-up design of carbohydrate materials.


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