scholarly journals Photoactivated biscarbocyanine dye with two conjugated chromophores: complexes with albumin, photochemical and phototoxic properties

2019 ◽  
Vol 18 (10) ◽  
pp. 2461-2468 ◽  
Author(s):  
Alexandra S. Radchenko ◽  
Alexey A. Kostyukov ◽  
Alina A. Markova ◽  
Alexander A. Shtil ◽  
Tatiana D. Nekipelova ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Biscarbocyanine dye forms two types of complexes with human serum albumin and has a high photocytotoxicity towards tumor cells.

Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells

Nitric Oxide ◽  
2010 ◽  
Vol 22 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Naohisa Katayama ◽  
Keisuke Nakajou ◽  
Yu Ishima ◽  
Shotaro Ikuta ◽  
Jun-ichi Yokoe ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Ruthenium (II) Complexes Interact with Human Serum Albumin and Induce Apoptosis of Tumor Cells

2014 ◽  
Vol 163 (1-2) ◽  
pp. 266-274 ◽  
Author(s):  
Jing Sun ◽  
Yongchao Huang ◽  
Chuping Zheng ◽  
Yanhui Zhou ◽  
Ying Liu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Targeted photosensitizer nanoconjugates based on human serum albumin selectively kill tumor cells upon photo-irradiation

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50572-50579 ◽  
Author(s):  
Cheng-Yi Tang ◽  
Yong-hui Liao ◽  
Guo-Sheng Tan ◽  
Xiao-Ming Wang ◽  
Gui-Hua Lu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Small and non-toxic nanoconjugates RGD–HSA–Ce6 could provide targeted and effective photodynamic therapy of tumor cells.

Trastuzumab decorated methotrexate–human serum albumin conjugated nanoparticles for targeted delivery to HER2 positive tumor cells

2012 ◽  
Vol 47 (2) ◽  
pp. 331-340 ◽  
Author(s):  
Azade Taheri ◽  
Rassoul Dinarvand ◽  
Fatemeh Atyabi ◽  
Mohammad Hossein Ghahremani ◽  
Seyed Nasser Ostad
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Her2 Positive

Ruthenium (II) complexes binding to human serum albumin and inducing apoptosis of tumor cells

2012 ◽  
Vol 24 ◽  
pp. 104-109 ◽  
Author(s):  
Yanyu Liu ◽  
Qianqian Yu ◽  
Chuan Wang ◽  
Dongdong Sun ◽  
Yongchao Huang ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Targeted Delivery of Methotrexate to Tumor Cells Using Biotin Functionalized Methotrexate-Human Serum Albumin Conjugated Nanoparticles

2011 ◽  
Vol 7 (6) ◽  
pp. 743-753 ◽  
Author(s):  
Azade Taheri ◽  
Rassoul Dinarvand ◽  
Fatemeh Atyabi ◽  
Faranak Nouri ◽  
Fatemeh Ahadi ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells ◽  
Targeted Delivery

scholarly journals The Interaction of Temozolomide with Blood Components Suggests the Potential Use of Human Serum Albumin as a Biomimetic Carrier for the Drug

Biomolecules ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. 1015
Author(s):  
Marta Rubio-Camacho ◽  
José A. Encinar ◽  
María José Martínez-Tomé ◽  
Rocío Esquembre ◽  
C. Reyes Mateo
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells ◽  
Membrane Surface ◽  
Hydrolytic Stability ◽  
Tryptophan Residue ◽  
Blood Components ◽  
Dynamics Simulations ◽  
Potential Use

The interaction of temozolomide (TMZ) (the main chemotherapeutic agent for brain tumors) with blood components has not been studied at the molecular level to date, even though such information is essential in the design of dosage forms for optimal therapy. This work explores the binding of TMZ to human serum albumin (HSA) and alpha-1-acid glycoprotein (AGP), as well as to blood cell-mimicking membrane systems. Absorption and fluorescence experiments with model membranes indicate that TMZ does not penetrate into the lipid bilayer, but binds to the membrane surface with very low affinity. Fluorescence experiments performed with the plasma proteins suggest that in human plasma, most of the bound TMZ is attached to HSA rather than to AGP. This interaction is moderate and likely mediated by hydrogen-bonding and hydrophobic forces, which increase the hydrolytic stability of the drug. These experiments are supported by docking and molecular dynamics simulations, which reveal that TMZ is mainly inserted in the subdomain IIA of HSA, establishing π-stacking interactions with the tryptophan residue. Considering the overexpression of albumin receptors in tumor cells, our results propose that part of the administered TMZ may reach its target bound to plasma albumin and suggest that HSA-based nanocarriers are suitable candidates for designing biomimetic delivery systems that selectively transport TMZ to tumor cells.

II. Lokalisation der Placenta mit 113Inm- Human-Serum-Albumin

1969 ◽  
Vol 08 (01) ◽  
pp. 15-21 ◽  
Author(s):  
K. E. Scheer ◽  
J. Heep ◽  
W. Maier-Borst ◽  
W. J. Lorenz ◽  
H. Sinn ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Vena Cava ◽  
Placenta Praevia ◽  
Wird Eine

ZusammenfassungNach tierexperimentellen Voruntersuchungen wurde die Placentographie mit trägerfreiem 113Inm -HSA als klinische Methode eingeführt. Vor Amniocentesen und bei Verdacht auf Placenta praevia werden Placentographien geschrieben. Den Schwangeren wird eine Aktivität von 500 μCi in die Cubitalvene injiziert. Die der Aktivität entsprechende Indiummenge ist kleiner als 0,1 ng. Die fetale Strahlenbelastung liegt unter lOmrad. Bei Anwendung von 113Inm-HSA entfällt eine Blockade der mütterlichen und fetalen Schilddrüsen. Die genaue Abgrenzung einer Placenta praevia wird nicht durch eine Blasenaktivität beeinträchtigt.Es wurden bisher 19 Placentalokalisationen durchgeführt. In allen Fällen konnte der Placentasitz eindeutig festgestellt werden. Bedingt durch die lange Liegezeit beim Aufnehmen eines Szintigramms kam es in zwei Fällen zu einem Vena-Cava-Kompressions-Syndrom. Zur Verhinderung dieser klinischen Zwischenfälle werden inzwischen Placentographien mit der Anger-Kamera aufgenommen. Mit Hilfe des divergierenden Kollimators konnte der gesamte Abdominalbereich erfaßt werden. Die Aufnahmezeit konnte auf 7 — 10 Minuten verkürzt werden. Die intravenöse injizierte Aktivität betrug bei dieser Methode ebenfalls 500 μCi. Der diagnostische Aussagewert der Kamerabilder ist szintigraphischen Aufnahmen gleichwertig.

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