Targeted photosensitizer nanoconjugates based on human serum albumin selectively kill tumor cells upon photo-irradiation

RSC Advances ◽  
2015 ◽  
Vol 5 (62) ◽  
pp. 50572-50579 ◽  
Author(s):  
Cheng-Yi Tang ◽  
Yong-hui Liao ◽  
Guo-Sheng Tan ◽  
Xiao-Ming Wang ◽  
Gui-Hua Lu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Small and non-toxic nanoconjugates RGD–HSA–Ce6 could provide targeted and effective photodynamic therapy of tumor cells.

Nitrosylated human serum albumin (SNO-HSA) induces apoptosis in tumor cells

Nitric Oxide ◽  
2010 ◽  
Vol 22 (4) ◽  
pp. 259-265 ◽  
Author(s):  
Naohisa Katayama ◽  
Keisuke Nakajou ◽  
Yu Ishima ◽  
Shotaro Ikuta ◽  
Jun-ichi Yokoe ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

scholarly journals Human serum albumin nanoparticles loaded with phthalocyanine dyes for potential use in photodynamic therapy for atherosclerotic plaques

2019 ◽  
Vol 2 (2) ◽  
pp. 279-302 ◽  
Author(s):  
Subhadeep Banerjee ◽  
Jayeeta Sengupta ◽  
Ana Isabel Aljarilla ◽  
Francesca Setaro ◽  
Petri Makinen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Contrast Agent ◽  
Human Serum ◽  
Zinc Phthalocyanine ◽  
Atherosclerotic Plaques ◽  
Albumin Nanoparticles ◽  
Vulnerable Plaques ◽  
Potential Use

Diseases caused by obstruction or rupture of vulnerable plaques in the arterial walls such as cardiovascular infarction or stroke are the leading cause of death in the world. In the present work, we developed human serum albumin nanoparticles loaded by physisorption with zinc phthalocyanine, TT1, mainly used for industrial application as near-infrared photosensitizer and compared these to HSA NPs loaded with the well-known silicone phthalocyanine (Pc4). The use of NIR light allows for better tissue penetration, while the use of nanoparticles permits high local concentrations. The particles were characterized and tested for toxicity and stability as well as for their potential use as a contrast agent and NIR photosensitizer for photodynamic therapy in cardiovascular disease. We focused on the distribution of the nanoparticles in RAW264.7 macrophage cells and atherosclerotic mice. The nanoparticles had an average size of 120 nm according to dynamic light scattering, good loading capacity for zinc phthalocyanine, and satisfying stability in 50% (v/v) fetal bovine serum for 8 hours and in an aqueous environment at 4°C for 4–6 weeks. Under light irradiation we found a high production of singlet oxygen and the products showed no dark toxicity in vitro with macrophages (the target cells in vulnerable plaques), but at a low g/mL nanoparticle concentration killed efficiently the macrophages upon LED illumination. Injection of the contrast agent in atherosclerotic mice led to a visible fluorescence signal of zinc phthalocyanine in the atherosclerotic plaque at 30 minutes and in the lungs with a fast clearance of the nanoparticles. Zinc phthalocyanine loaded human serum albumin nanoparticles present an interesting candidate for the visualization and potentially photodynamic treatment of macrophages in atherosclerotic plaques.

Ruthenium (II) Complexes Interact with Human Serum Albumin and Induce Apoptosis of Tumor Cells

2014 ◽  
Vol 163 (1-2) ◽  
pp. 266-274 ◽  
Author(s):  
Jing Sun ◽  
Yongchao Huang ◽  
Chuping Zheng ◽  
Yanhui Zhou ◽  
Ying Liu ◽  
...  
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells

Trastuzumab decorated methotrexate–human serum albumin conjugated nanoparticles for targeted delivery to HER2 positive tumor cells

2012 ◽  
Vol 47 (2) ◽  
pp. 331-340 ◽  
Author(s):  
Azade Taheri ◽  
Rassoul Dinarvand ◽  
Fatemeh Atyabi ◽  
Mohammad Hossein Ghahremani ◽  
Seyed Nasser Ostad
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Tumor Cells ◽  
Targeted Delivery ◽  
Her2 Positive

Hydrophobic IR780 encapsulated in biodegradable human serum albumin nanoparticles for photothermal and photodynamic therapy

2015 ◽  
Vol 14 ◽  
pp. 61-69 ◽  
Author(s):  
Chenxiao Jiang ◽  
Hao Cheng ◽  
Ahu Yuan ◽  
Xiaolei Tang ◽  
Jinhui Wu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Albumin Nanoparticles
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