A base-promoted cascade reaction of α,β-unsaturated N-tosylhydrazones with o-hydroxybenzyl alcohols: highly regioselective synthesis of N-sec-alkylpyrazoles

2019 ◽  
Vol 17 (37) ◽  
pp. 8561-8570 ◽  
Author(s):  
Lian-Mei Chen ◽  
Juan Zhao ◽  
An-Jie Xia ◽  
Xiao-Qiang Guo ◽  
Ya Gan ◽  
...  
Keyword(s):  
Efficient Method ◽  
Cascade Reaction ◽  
Regioselective Synthesis

An efficient method for the synthesis of N-sec-alkylpyrazoles via a cascade reaction of α,β-unsaturated N-tosylhydrazones with ortho-hydroxybenzyl alcohols has been developed.

Copper(II)-Promoted Oxidation/[3+2]Cycloaddition/Aromatization Cascade: Efficient Synthesis of Tetrasubstituted NH-Pyrrole from Chalcones and Iminodiacetates

Synlett ◽  
2019 ◽  
Vol 30 (12) ◽  
pp. 1442-1446 ◽  
Author(s):  
Zhang-qi Lin ◽  
Chao-dong Li ◽  
Zi-chun Zhou ◽  
Shuai Xue ◽  
Jian-rong Gao ◽  
...  
Keyword(s):  
Efficient Method ◽  
Cascade Reaction ◽  
Oxidative Cyclization ◽  
Efficient Synthesis ◽  
Reaction Conditions ◽  
Highly Efficient ◽  
Wide Range ◽  
Reaction Proceeds

A simple and highly efficient method for the preparation of tetrasubstituted NH-pyrrole from a wide range of chalcones and diethyl iminodiacetates via a Cu(OAc)2-promoted oxidation/[3+2]cycloaddition/aromatization cascade reaction has been developed. This reaction proceeds through dehydrogenations, deamination, and oxidative cyclization, affording the corresponding products in good to excellent yields. This convenient methodology for constructing tetrasubstituted NH-pyrroles has several advantages over existing methods, such as the use of easily accessible chalcones and readily available diethyl iminodiacetates, and mild reaction conditions. A wide range of substrates are tolerated.

Electrochemical-mediated fixation of CO2: three-component synthesis of carbamate compounds from CO2, amines and N-alkenylsulfonamides

2021 ◽  
Author(s):  
Ting-Kai Xiong ◽  
Xue-Qi Zhou ◽  
Min Zhang ◽  
Hai-Tao Tang ◽  
Ying-Ming Pan ◽  
...  
Keyword(s):  
Efficient Method ◽  
Environmentally Friendly ◽  
Cascade Reaction

An electrocatalyzed three-component cascade reaction of CO2, amines, and N-alkenylsulfonamides is developed, providing an environmentally friendly and efficient method of synthesizing a series of new carbamate compounds. This reaction meets...

Regioselective synthesis of substituted thiazoles via cascade reactions from 3-chlorochromones and thioamides

2020 ◽  
Vol 18 (31) ◽  
pp. 6162-6170
Author(s):  
Tianzi Dai ◽  
Chen Cui ◽  
Xueyu Qi ◽  
Yanshu Cheng ◽  
Qian He ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Environmentally Benign

An efficient and regioselective strategy to synthesize substituted thiazoles via a cascade reaction in an environmentally benign medium was developed.

One-pot cascade synthesis of 2,3-disubstituted 2,3-dihydrobenzofurans via ortho-quinone methide intermediates generated in situ

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14892-14896 ◽  
Author(s):  
Abdul kadar Shaikh ◽  
George Varvounis
Keyword(s):  
Cascade Reaction ◽  
Regioselective Synthesis ◽  
Quinone Methide ◽  
One Pot

A simple and efficient one-pot cascade reaction for the regioselective synthesis of trans or cis/trans-2,3-disubstituted 2,3-dihydrobenzofurans, is described.

K2CO3 catalyzed regioselective synthesis of thieno[2,3-b]thiochromen-4-one oximes: access to the corresponding amine and nitroso derivatives

2017 ◽  
Vol 15 (26) ◽  
pp. 5625-5634 ◽  
Author(s):  
Karuna Mahato ◽  
Prasanta Ray Bagdi ◽  
Abu T. Khan
Keyword(s):  
Efficient Method ◽  
Cyclization Reaction ◽  
Regioselective Synthesis

An unprecedented and efficient method for the synthesis of useful thieno[2,3-b]thiochromen-4-one oximes is accomplished via a thio[3 + 2] cyclization reaction of 4-hydroxydithiocoumarins and trans-β-nitrostyrenes in the presence of 10 mol% K2CO3 in ethanol under reflux conditions.

A Novel Copper-Assisted Synthesis Method for Dihydropyrano[2.3-b]Indole-4-ones by Domino Cascade Reaction

2021 ◽  
Author(s):  
Yang Luo ◽  
Xue Zhong ◽  
Jiangkun Huang ◽  
Ling He
Keyword(s):  
Synthesis Method ◽  
Cascade Reaction ◽  
Reaction Process ◽  
Regioselective Synthesis ◽  
One Pot

A novel copper-catalyzed cascade interolecular and intramolecular oxidation/cyclization domino one-pot reaction process for the regioselective synthesis of dihydropyrano[2.3-b]indol-4(9H)-ones has been successfully developed. In this methodology, it is proposed for the...

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