A convenient approach for the preparation of imidazo[1,2-a]-fused bicyclic frameworks via IBX/NIS promoted oxidative annulation

2019 ◽  
Vol 17 (40) ◽  
pp. 9001-9007 ◽  
Author(s):  
Zsófia Makra ◽  
László G. Puskás ◽  
Iván Kanizsai
Keyword(s):  
Oxidative Cyclization ◽  
One Pot ◽  
Convenient Approach ◽  
Intramolecular Oxidative Cyclization

IBX/NIS induced intramolecular oxidative cyclization of Mannich substrates is reported, affording highly diverse imidazo[1,2-a]-pyridines, -pyrimidines and -pyrazines in up to 93% isolated yield. In addition, one-pot procedure is also represented.

scholarly journals 2-Aryl-6-Polyfluoroalkyl-4-Pyrones as Promising RF-Building-Blocks: Synthesis and Application for Construction of Fluorinated Azaheterocycles

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4415
Author(s):  
Sergey A. Usachev ◽  
Diana I. Nigamatova ◽  
Daria K. Mysik ◽  
Nikita A. Naumov ◽  
Dmitrii L. Obydennov ◽  
...  
Keyword(s):  
Direct Synthesis ◽  
Building Blocks ◽  
Oxidative Cyclization ◽  
One Pot ◽  
Synthetic Application ◽  
General Method

A convenient and general method for the direct synthesis of 2-aryl-6-(trifluoromethyl)-4-pyrones and 2-aryl-5-bromo-6-(trifluoromethyl)-4-pyrones has been developed on the basis of one-pot oxidative cyclization of (E)-6-aryl-1,1,1-trifluorohex-5-ene-2,4-diones via a bromination/dehydrobromination approach. This strategy was also applied for the preparation of 2-phenyl-6-polyfluoroalkyl-4-pyrones and their 5-bromo derivatives. Conditions of chemoselective enediones bromination were found and the key intermediates of the cyclization of bromo-derivatives to 4-pyrones were characterized. Synthetic application of the prepared 4-pyrones has been demonstrated for the construction of biologically important CF3-bearing azaheterocycles, such as pyrazoles, pyridones, and triazoles.

ChemInform Abstract: I2Promoted Domino Oxidative Cyclization for One-Pot Synthesis of 2-Acylbenzothiazoles via Metal-Free sp3C-H Functionalization.

ChemInform ◽  
2012 ◽  
Vol 43 (52) ◽  
pp. no-no
Author(s):  
Yan-Ping Zhu ◽  
Mi Lian ◽  
Feng-Cheng Jia ◽  
Mei-Cai Liu ◽  
Jing-Jing Yuan ◽  
...  
Keyword(s):  
Oxidative Cyclization ◽  
One Pot ◽  
Metal Free ◽  
One Pot Synthesis

scholarly journals Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Misako Okada ◽  
Yuko Kishibe ◽  
Kanako Ide ◽  
Toshiyuki Takahashi ◽  
Teruaki Hasegawa
Keyword(s):  
Click Chemistry ◽  
Water Solubility ◽  
One Pot ◽  
Lectin Affinity ◽  
Convenient Approach ◽  
Porphyrin Core ◽  
Glycosylated Porphyrins

Easy, quantitative, and one-pot introduction of eight β-lactoside-modules onto a porphyrin-core was achieved through Cu+-catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and β-lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.

An Efficient and Convenient Approach to the Synthesis of Benzopyrans by a Three-Component Coupling of One-Pot Reaction

Synlett ◽  
2003 ◽  
pp. 2001-2004 ◽  
Author(s):  
Tong-Shou Jin ◽  
Jin-Chong Xiao ◽  
Su-Juan Wang ◽  
Tong-Shuang Li ◽  
Xin-Ru Song
Keyword(s):  
One Pot ◽  
Convenient Approach ◽  
Three Component Coupling

Convenient Synthesis of Oxazolo[5,4-h]pyrrolo[4,3,2-de]quino­lones via Hypervalent Iodine Mediated Intramolecular Oxidative Cyclization

Synthesis ◽  
2017 ◽  
Vol 28 (19) ◽  
pp. 4517-4522
Author(s):  
Li-Ping Sun ◽  
Chun-Meng Wang ◽  
Sheng-Wei Yang ◽  
Kai-Xiang Tang ◽  
Tian-Hong Gao ◽  
...  
Keyword(s):  
Functional Groups ◽  
Practical Method ◽  
Oxidative Cyclization ◽  
Hypervalent Iodine ◽  
Air Atmosphere ◽  
Convenient Synthesis ◽  
Reaction Proceeds ◽  
Intramolecular Oxidative Cyclization

A convenient and practical method has been developed for the synthesis of substituted oxazolo[5,4-h]pyrrolo[4,3,2-de]quinolones via the intramolecular oxidative cyclization by using PIFA as oxidant and TMSOTf as additive in DCE under an air atmosphere. The reaction proceeds in good yields and has good functional groups tolerance.

ChemInform Abstract: Convenient Approach for the One-Pot, Three-Component Synthesis of Triheterocyclic 4H-Pyrimido[2,1-b]benzothiazole Derivatives Using TBAHS.

ChemInform ◽  
2013 ◽  
Vol 44 (21) ◽  
pp. no-no
Author(s):  
Lingaiah Nagarapu ◽  
Hanmant K. Gaikwad ◽  
Jyothsna Devi Palem ◽  
Ramineni Venkatesh ◽  
Rajashaker Bantu ◽  
...  
Keyword(s):  
One Pot ◽  
Benzothiazole Derivatives ◽  
Convenient Approach ◽  
The One
Sign in / Sign up

Export Citation Format

Share Document