scholarly journals Convenient Approach to Access Octa-Glycosylated Porphyrins via “Click Chemistry”

2009 ◽  
Vol 2009 ◽  
pp. 1-9 ◽  
Author(s):  
Misako Okada ◽  
Yuko Kishibe ◽  
Kanako Ide ◽  
Toshiyuki Takahashi ◽  
Teruaki Hasegawa
Keyword(s):  
Click Chemistry ◽  
Water Solubility ◽  
One Pot ◽  
Lectin Affinity ◽  
Convenient Approach ◽  
Porphyrin Core ◽  
Glycosylated Porphyrins

Easy, quantitative, and one-pot introduction of eight β-lactoside-modules onto a porphyrin-core was achieved through Cu+-catalyzed chemoselective coupling (click chemistry) between a porphyrin carrying eight alkyne-terminals and β-lactosyl azides. The obtained porphyrin-based glycocluster shows not only good water-solubility but also strong/specific lectin-affinity.

Combining Oxidative N-Heterocyclic Carbene Catalysis with Click Chemistry: A Facile One-Pot Approach to 1,2,3-Triazole Derivatives

2013 ◽  
Vol 8 (7) ◽  
pp. 1489-1496 ◽  
Author(s):  
B. T. Ramanjaneyulu ◽  
Virsinha Reddy ◽  
Panjab Arde ◽  
Sriram Mahesh ◽  
R. Vijaya Anand
Keyword(s):  
Click Chemistry ◽  
One Pot ◽  
Triazole Derivatives

scholarly journals Oxidation-Induced “One-Pot” Click Chemistry

2021 ◽  
Author(s):  
Bauke Albada ◽  
Jordi F. Keijzer ◽  
Han Zuilhof ◽  
Floris van Delft
Keyword(s):  
Click Chemistry ◽  
One Pot

An Efficient and Convenient Approach to the Synthesis of Benzopyrans by a Three-Component Coupling of One-Pot Reaction

Synlett ◽  
2003 ◽  
pp. 2001-2004 ◽  
Author(s):  
Tong-Shou Jin ◽  
Jin-Chong Xiao ◽  
Su-Juan Wang ◽  
Tong-Shuang Li ◽  
Xin-Ru Song
Keyword(s):  
One Pot ◽  
Convenient Approach ◽  
Three Component Coupling

Adequate Reducing Conditions Enable Conjugation of Oxidized Peptides to Polymers by One-Pot Thiol Click Chemistry

2018 ◽  
Vol 29 (11) ◽  
pp. 3866-3876 ◽  
Author(s):  
Gwendoline Tallec ◽  
Celestine Loh ◽  
Benoit Liberelle ◽  
Araceli Garcia-Ac ◽  
Sung Vo Duy ◽  
...  
Keyword(s):  
Click Chemistry ◽  
One Pot ◽  
Reducing Conditions

ChemInform Abstract: Combining Oxidative N-Heterocyclic Carbene Catalysis with Click Chemistry: A Facile One-Pot Approach to 1,2,3-Triazole Derivatives.

ChemInform ◽  
2013 ◽  
Vol 44 (46) ◽  
pp. no-no
Author(s):  
B. T. Ramanjaneyulu ◽  
Virsinha Reddy ◽  
Panjab Arde ◽  
Sriram Mahesh ◽  
R. Vijaya Anand
Keyword(s):  
Click Chemistry ◽  
One Pot ◽  
Triazole Derivatives

ChemInform Abstract: Convenient Approach for the One-Pot, Three-Component Synthesis of Triheterocyclic 4H-Pyrimido[2,1-b]benzothiazole Derivatives Using TBAHS.

ChemInform ◽  
2013 ◽  
Vol 44 (21) ◽  
pp. no-no
Author(s):  
Lingaiah Nagarapu ◽  
Hanmant K. Gaikwad ◽  
Jyothsna Devi Palem ◽  
Ramineni Venkatesh ◽  
Rajashaker Bantu ◽  
...  
Keyword(s):  
One Pot ◽  
Benzothiazole Derivatives ◽  
Convenient Approach ◽  
The One

scholarly journals A mesostructured hybrid CTA–silica carrier for curcumin delivery

2020 ◽  
Vol 96 (1) ◽  
pp. 236-246
Author(s):  
Marta Gallo ◽  
Fabio Giudice ◽  
Mauro Banchero ◽  
Silvia Ronchetti ◽  
Luigi Manna ◽  
...  
Keyword(s):  
Water Solubility ◽  
Uv Spectroscopy ◽  
Sol Gel ◽  
Topical Administration ◽  
Release Mechanism ◽  
Active Principle ◽  
One Pot ◽  
Drug Release Mechanism ◽  
Sol Gel Synthesis ◽  
First Time

Abstract Curcumin is a natural active principle with antioxidant, antibacterial and anti-inflammatory properties. Its use is limited by a low water solubility and fast degradation rate, which hinder its bioavailability. To overcome this problem, curcumin can be delivered through a carrier, which protects the drug molecule and enhances its pharmacological effects. The present work proposes a simple one-pot sol–gel synthesis to obtain a hybrid carrier for curcumin delivery. The hybrid consists of a mesostructured matrix of amorphous silica, which stabilizes the carrier, and hexadecyltrimethylammonium (CTA), a surfactant where curcumin is dissolved to increase its water solubility. The carrier was characterized in terms of morphology (FESEM), physicochemical properties (XRD, FTIR, UV spectroscopy) and release capability in pseudo-physiological solutions. Results show that curcumin molecules were entrapped, for the first time, in a silica-surfactant mesostructured hybrid carrier. The hybrid carrier successfully released curcumin in artificial sweat and in a phosphate buffer saline solution, so confirming its efficacy in increasing curcumin water solubility. The proposed drug release mechanism relies on the degradation of the carrier, which involves the concurrent release of silicon. This suggests strong potentialities for topical administration applications, since curcumin is effective against many dermal diseases while silicon is beneficial to the skin.

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