scholarly journals Tumour-targeting photosensitisers for one- and two-photon activated photodynamic therapy

2019 ◽  
Vol 17 (27) ◽  
pp. 6585-6594 ◽  
Author(s):  
Sébastien Jenni ◽  
Angélique Sour ◽  
Frédéric Bolze ◽  
Barbara Ventura ◽  
Valérie Heitz
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Near Infrared ◽  
Tumour Targeting ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Efficient receptor-mediated delivery of a folate-targeted photosensitiser to kill cancer cells following two-photon excitation in the near-infrared is demonstrated.

scholarly journals Two-Photon–NIR-II Antimicrobial Graphene-Nanoagent for Ultraviolet–NIR Imaging and Photoinactivation

2021 ◽  
Author(s):  
WEN-SHUO KUO ◽  
Chia-Yuan Chang ◽  
Ping-Ching Wu ◽  
Jiu-Yao Wang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Chemical Modification ◽  
Near Infrared ◽  
Photon Absorption ◽  
Excitation Wavelength ◽  
Strong Electron ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Abstract BackgroundNitrogen doping and amino-group functionalization, which result in strong electron donation, can be achieved through chemical modification. Large π-conjugated systems of graphene quantum dot (GQD)-based materials acting as electron donors can be chemically manipulated with low two-photon excitation energy in a short photoexcitation time for improving the charge transfer efficiency of sorted nitrogen-doped amino acid–functionalized GQDs (sorted amino-N-GQDs). ResultsIn this study, a self-developed femtosecond Ti-sapphire laser optical system (222.7 nJ pixel−1 with 100-170 scans, approximately 0.65-1.11 s of total effective exposure times; excitation wavelength: 960 nm in the near-infrared II region) was used for chemical modification. The sorted amino-N-GQDs exhibited enhanced two-photon absorption, post-two-photon excitation stability, two-photon excitation cross-section, and two-photon luminescence through the radiative pathway. The lifetime and quantum yield of the sorted amino-N-GQDs decreased and increased, respectively. Furthermore, the sorted amino-N-GQDs exhibited excitation-wavelength-independent photoluminescence in the near-infrared region and generated reactive oxygen species after two-photon excitation. An increase in the size of the sorted amino-N-GQDs boosted photochemical and electrochemical efficacy and resulted in high photoluminescence quantum yield and highly efficient two-photon photodynamic therapy. ConclusionThe sorted dots can be used in two-photon contrast probes for tracking and localizing analytes during two-photon imaging in a biological environment and for conducting two-photon photodynamic therapy for eliminating infectious microbes.

Two-photon excitation nanoparticles for photodynamic therapy

2016 ◽  
Vol 45 (24) ◽  
pp. 6725-6741 ◽  
Author(s):  
Yizhong Shen ◽  
Adam J. Shuhendler ◽  
Deju Ye ◽  
Jing-Juan Xu ◽  
Hong-Yuan Chen
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Integration of the two-photon excitation (TPE) technique and nanomaterials to construct TPE nanoparticle-based photosensitizers for PDT is summarized and reviewed.

Control of Photobleaching in Photodynamic Therapy Using the Photodecarbonylation Reaction of Ruthenium Phthalocyanine Complexes via Stepwise Two-Photon Excitation

2008 ◽  
Vol 112 (10) ◽  
pp. 3138-3143 ◽  
Author(s):  
Kazuyuki Ishii ◽  
Masahiko Shiine ◽  
Yoshitaka Shimizu ◽  
Shun-ichi Hoshino ◽  
Hisaku Abe ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Two Photon ◽  
Photon Excitation ◽  
Two Photon Excitation

Lysosome-targetable polythiophene nanoparticles for two-photon excitation photodynamic therapy and deep tissue imaging

2017 ◽  
Vol 5 (20) ◽  
pp. 3651-3657 ◽  
Author(s):  
Shaojing Zhao ◽  
Guangle Niu ◽  
Feng Wu ◽  
Li Yan ◽  
Hongyan Zhang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Yield ◽  
Fluorescence Imaging ◽  
Cross Section ◽  
Tissue Imaging ◽  
Deep Tissue ◽  
Two Photon ◽  
Photon Excitation ◽  
Deep Tissue Imaging ◽  
Two Photon Excitation

Polythiophene nanoparticles with large TPA cross section and high1O2generation quantum yield have been developed for simultaneous lysosome-targetable fluorescence imaging and photodynamic therapy.

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