Magnetic biohybrid micromotors with high maneuverability for efficient drug loading and targeted drug delivery

Nanoscale ◽  
2019 ◽  
Vol 11 (39) ◽  
pp. 18382-18392 ◽  
Author(s):  
Mengmeng Sun ◽  
Xinjian Fan ◽  
Xianghe Meng ◽  
Jianmin Song ◽  
Weinan Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Recent Progress ◽  
Drug Loading ◽  
Targeted Drug ◽  
Immense Potential

Recent progress of untethered mobile micromotors has shown immense potential for targeted drug delivery in vivo.

scholarly journals Chitosan overlaid Fe3O4/rGO nanocomposite for targeted drug delivery, imaging, and biomedical applications

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Viswanathan Karthika ◽  
Mohamad S. AlSalhi ◽  
Sandhanasamy Devanesan ◽  
Kasi Gopinath ◽  
Ayyakannu Arumugam ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Targeted Drug Delivery ◽  
Drug Carrier ◽  
Drug Loading ◽  
Antioxidant Properties ◽  
Targeted Drug ◽  
Loading Amount

Abstract A hybrid and straightforward nanosystem that can be used simultaneously for cancer-targeted fluorescence imaging and targeted drug delivery in vitro was reported in this study. A chitosan (CS) polymer coated with reduced graphene oxide (rGO) and implanted with Fe3O4 nanoparticles was fabricated. The fundamental physicochemical properties were confirmed via FT-IR, XRD, FE-SEM, HR-TEM, XPS, and VSM analysis. The in vivo toxicity study in zebrafish showed that the nanocomposite was not toxic. The in vitro drug loading amount was 0.448 mg/mL−1 for doxorubicin, an anticancer therapeutic, in the rGO/Fe3O4/CS nanocomposite. Furthermore, the pH-regulated release was observed using folic acid. Cellular uptake and multimodal imaging revealed the benefit of the folic acid-conjugated nanocomposite as a drug carrier, which remarkably improves the doxorubicin accumulation inside the cancer cells over-express folate receptors. The rGO/Fe3O4/CS nanocomposite showed enhanced antibiofilm and antioxidant properties compared to other materials. This study's outcomes support the use of the nanocomposite in targeted chemotherapy and the potential applications in the polymer, cosmetic, biomedical, and food industries.

scholarly journals Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

2018 ◽  
Author(s):  
Q Zhong ◽  
BC Yoon ◽  
M Aryal ◽  
JB Wang ◽  
A Karthik ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Focused Ultrasound ◽  
Drug Loading ◽  
The Body ◽  
Clinical Translation ◽  
Drug Infusion ◽  
Targeted Drug ◽  
Perfluorocarbon Nanoemulsions

ABSTRACTCatheter-based intra-arterial drug therapies have proven effective for a range of oncologic, neurologic, and cardiovascular applications. However, these procedures are limited by their invasiveness, as well as the relatively broad drug spatial distribution that is achievable with selective arterial catheterization. The ideal technique for local pharmacotherapy would be noninvasive and would flexibly deliver a given drug to any region of the body. Combining polymeric perfluorocarbon nanoemulsions with existent clinical focused ultrasound systems could in principle enable noninvasive targeted drug delivery, but it has not been clear whether these nanoparticles could provide the necessary drug loading, stability, and generalizability across a range of drugs to meet these needs, beyond a few niche applications. Here, we directly address all of those challenges and fully develop polymeric perfluorocarbon nanoemulsions into a generalized platform for ultrasound-targeted drug delivery with high potential for clinical translation. We demonstrate that a wide variety of drugs may be effectively uncaged with ultrasound using these nanoparticles, with drug loading increasing with hydrophobicity. We also set the stage for clinical translation by delineating production protocols that hew to clinical standards and yield stable and optimized ultrasound-activated drug-loaded nanoemulsions. Finally, as a new potential clinical application for these nanoemulsions, we exhibit their in vivo efficacy and performance for cardiovascular applications, by achieving local vasodilation in the highest flow vessel of the body, the aorta. This work establishes the power of polymeric perfluorocarbon nanoemulsions as a clinically-translatable platform for effective noninvasive ultrasonic drug uncaging for myriad targets in the brain and body.

Transferrin Modified Graphene Oxide for Glioma-Targeted Drug Delivery: In Vitro and in Vivo Evaluations

2013 ◽  
Vol 5 (15) ◽  
pp. 6909-6914 ◽  
Author(s):  
Guodong Liu ◽  
He Shen ◽  
Jinning Mao ◽  
Liming Zhang ◽  
Zhen Jiang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Targeted Drug Delivery ◽  
Modified Graphene Oxide ◽  
Targeted Drug ◽  
Modified Graphene
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