Enhancement of ultralow-intensity NIR light-triggered photodynamic therapy based on exo- and endogenous synergistic effects through combined glutathione-depletion chemotherapy

Nanoscale ◽  
2019 ◽  
Vol 11 (27) ◽  
pp. 13078-13088 ◽  
Author(s):  
Jun-hui Shi ◽  
Tian-ran Wang ◽  
Yong-qiang You ◽  
Muhammad Luqman Akhtar ◽  
Zong-jun Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Synergistic Effects ◽  
Glutathione Depletion ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

An ultralow-intensity (0.30 W cm−2) near-infrared light-triggered PDT was developed and enhanced through combination of GSH-depletion chemotherapy based on both exo- and endogenous synergistic effects.

Ultralow-intensity near infrared light synchronously activated collaborative chemo/photothermal/photodynamic therapy

2020 ◽  
Vol 8 (2) ◽  
pp. 607-618 ◽  
Author(s):  
Renlu Han ◽  
Keqi Tang ◽  
Yafei Hou ◽  
Jiancheng Yu ◽  
Chenlu Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

An ultralow-intensity 808 nm NIR light with 0.25 W cm−2 synchronously activated collaborative Chemo/Photothermal/Photodynamic therapy system was developed.

A Near-Infrared Light-Excitable Immunomodulating Nano-photosensitizer for Effective Photoimmunotherapy

2021 ◽  
Author(s):  
Yadan Zheng ◽  
Zhanzhan Zhang ◽  
Qi Liu ◽  
Ying Wang ◽  
Jialei Hao ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Immune Responses ◽  
Near Infrared ◽  
Tumor Ablation ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Therapeutic Efficiency ◽  
Immunosuppressive Tumor Microenvironment

Photodynamic therapy has great potential for tumor ablation and the activation of antitumor immune responses. However, its overall therapeutic efficiency is often limited by the immunosuppressive tumor microenvironment. We developed...

Detection of residual varicose veins with near infrared light in the early period after varicose surgery and near infrared light assisted sclerotherapy

Vascular ◽  
2021 ◽  
pp. 170853812110514
Author(s):  
Nail Kahraman ◽  
Gündüz Yümün ◽  
Deniz Demir ◽  
Kadir K Özsin ◽  
Sadık A Sünbül ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Saphenous Vein ◽  
Venous Insufficiency ◽  
Near Infrared ◽  
Varicose Veins ◽  
Infrared Light ◽  
Foam Sclerotherapy ◽  
Near Infrared Light ◽  
Nir Light ◽  
Male Patients

Objectives Varicose veins that cannot be seen with the naked eye can be easily detected with Near Infrared (NIR) light. With a minimally invasive procedure performed with NIR light guided, the need for reoperation is reduced, while optimal treatment of venous insufficiency and symptoms is provided. In this study, the detection of residual varicose veins after varicose vein surgery using NIR light and the results of treatment of sclerotherapy were investigated. Methods In this retrospective study, treatment and clinical outcomes of patients’ who underwent NIR light-guided foam sclerotherapy for Clinical-Etiology-Anatomy-Pathophysiology (CEAP) (C1, C2) stage residual varicose veins after surgical varicose treatment between 2014 and 2017 were examined. Data of patients who underwent foam sclerotherapy with NIR light were collected and analyzed. Results A total of 151 patients and 171 lower extremity varicose veins were treated with surgery. 55 (35.7%) of the patients were male, and 96 (62.3%) were female. Their age ranges from 20 to 64, with an average age of 45.38. 4 (2.6%) of the patients had phlebectomy. 137 of patients (90.7%) had ligation of perforated veins, phlebectomy, and great saphenous vein (GSV) stripping, 10 of patients (6.6%) had GSV stripping, perforating vein ligation, phlebectomy, and small saphenous vein (SSV) surgery. No residual leakage was observed in the controls of GSV, SSV, and perforating veins by duplex ultrasonography (DUS). In the first month after varicose surgery, an average of 1.64 ± 1.05 sessions of sclerotherapy was applied to patients with CEAP C1, C2 stage residual varicose veins. 70 patients had one session of sclerotherapy, 37 patients had two sessions of sclerotherapy, 20 patients had three sessions of sclerotherapy, and 11 patients had four sessions of sclerotherapy administrated. The need for complementary therapy was required for all female patients; 13 of the male patients did not require complementary sclerotherapy. While single-session sclerotherapy was applied to most male patients (32 (58.18%), 10 (18.18%) patients received two sclerotherapy sessions. After completing sclerotherapy, 7 (4.63%) patients had superficial venous thrombosis, and 13 (8.60%) patients had hyperpigmentation. Conclusion Surgical treatment is a safe and effective technique in venous insufficiency. Nevertheless, residual varicose veins may remain, and these can be detected noninvasively with NIR light. Foam sclerotherapy with NIR light is a minimally invasive and safe treatment method for small residual varicose veins after the operation. We think that sclerotherapy with NIR light as a complementary treatment is a practical, reliable, and demanding treatment for clinical improvement, especially in female patients.

Near-infrared light-triggered drug release from UV-responsive diblock copolymer-coated upconversion nanoparticles with high monodispersity

2018 ◽  
Vol 6 (21) ◽  
pp. 3531-3540 ◽  
Author(s):  
Jun Xiang ◽  
Xia Tong ◽  
Feng Shi ◽  
Qiang Yan ◽  
Bing Yu ◽  
...  
Keyword(s):  
Drug Release ◽  
Diblock Copolymer ◽  
Near Infrared ◽  
Controlled Drug Release ◽  
Infrared Light ◽  
Upconversion Nanoparticles ◽  
Near Infrared Light ◽  
Nir Light ◽  
Triggered Drug Release

The preparation of a new near-infrared (NIR) light-responsive nanocarrier for controlled drug release is demonstrated.

scholarly journals 808 nm Near-Infrared Light-Excited UCNPs@mSiO2-Ce6-GPC3 Nanocomposites For Photodynamic Therapy In Liver Cancer

2019 ◽  
Vol Volume 14 ◽  
pp. 10009-10021 ◽  
Author(s):  
Jiahe Hu ◽  
Jialan Shi ◽  
Yingqian Gao ◽  
Wei Yang ◽  
Ping Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Liver Cancer ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light
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